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Biology and Biochemistry

D-Index
48
Citations
16031
World Ranking
18199
National Ranking
7435

Overview

Sasanka Ramanadham is affiliated with the University of Alabama at Birmingham in the United States. Their research spans the fields of biochemistry, genetics, molecular biology, and medicine, with a significant focus on molecular biology, endocrinology, diabetes and metabolism, surgery, genetics, and immunology.

The scientist's primary topics of research include pancreatic function and diabetes, diabetes and associated disorders, diet, metabolism, and disease, sphingolipid metabolism and signaling, extracellular vesicles in disease, complement system in diseases, and phagocytosis and immune regulation.

Sasanka Ramanadham has contributed to several recent papers including:

  • "Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate," 2020, Biomolecules
  • "Lipid mediators and biomarkers associated with type 1 diabetes development," 2020, JCI Insight
  • "Deletion of Gdf15 Reduces ER Stress-induced Beta-cell Apoptosis and Diabetes," 2022, Endocrinology
  • "A proteomic meta-analysis refinement of plasma extracellular vesicles," 2023, Scientific Data
  • "Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling," 2022, Molecular Metabolism

Their frequent co-authors are:

  • Xiaoyong Lei
  • Charles E. Chalfant
  • Abdulaziz Almutairi
  • Daniel Stephenson
  • Cyntanna C. Hawkins

Publications by Sasanka Ramanadham have appeared in journals and venues such as Diabetes, Biomolecules, Comprehensive Physiology, Scientific Data, and JCI Insight. The scientist has published most frequently in Diabetes and Biomolecules.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Biochemical Evidence for Nitric Oxide Formation from Streptozotocin in Isolated Pancreatic Islets

    John Turk;John A. Corbett;Sasanka Ramanadham;Alan Bohrer

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Calcium-independent phospholipases A2 and their roles in biological processes and diseases.

    Sasanka Ramanadham;Tomader Ali;Jason W. Ashley;Robert N. Bone

  • Male mice that do not express group VIA phospholipase A2 produce spermatozoa with impaired motility and have greatly reduced fertility.

    Shunzhong Bao;David J. Miller;Zhongmin Ma;Mary Wohltmann

  • Long-Term Effects of Vanadyl Treatment on Streptozocin-Induced Diabetes in Rats

    Raymond A Pederson;Sasanka Ramanadham;Alison M J Buchan;John H McNeill

  • Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet beta-cells.

    Richard W. Gross;Sasanka Ramanadham;Kelly K. Kruszka;Xianlin Han

  • Studies of the role of group VI phospholipase A2 in fatty acid incorporation, phospholipid remodeling, lysophosphatidylcholine generation, and secretagogue-induced arachidonic acid release in pancreatic islets and insulinoma cells.

    Sasanka Ramanadham;Fong-Fu Hsu;Alan Bohrer;Zhongmin Ma

  • Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin.

    Zhongmin Ma;Sasanka Ramanadham;Kirsten Kempe;Xiaoyuan Sherry Chi

  • Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentration.

    Sasanka Ramanadham;Richard W. Gross;Xianlin Han;John Turk

  • Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) That Arise from an Exon-skipping Mechanism of Alternative Splicing of the Transcript from the iPLA2 Gene on Chromosome 22q13.1

    Zhongmin Ma;Xiying Wang;William Nowatzke;Sasanka Ramanadham

  • Arachidonic acid release from aortic smooth muscle cells induced by [Arg8]vasopressin is largely mediated by calcium-independent phospholipase A2.

    John J. Lehman;Kathryn A. Brown;Sasanka Ramanadham;John Turk

  • Apoptosis of Insulin-Secreting Cells Induced by Endoplasmic Reticulum Stress Is Amplified by Overexpression of Group VIA Calcium-Independent Phospholipase A2 (iPLA2β) and Suppressed by Inhibition of iPLA2β†

    Sasanka Ramanadham;Fong-Fu Hsu;Sheng Zhang;Chun Jin

  • A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells

    Farideh Ghomashchi;Allison Stewart;Ying Hefner;Sasanka Ramanadham

  • Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express group via phospholipase A2 and effects of metabolic stress on glucose homeostasis

    Shunzhong Bao;Haowei Song;Mary Wohltmann;Sasanka Ramanadham

  • Calcium-independent Phospholipase A2 (iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis

    Xiaoyong Lei;Sheng Zhang;Alan Bohrer;Sasanka Ramanadham

  • Amplification of Insulin Secretion by Lipid Messengers

    John Turk;Richard W Gross;Sasanka Ramanadham

  • Electrospray Ionization Mass Spectrometric Analyses of Phospholipids from Rat and Human Pancreatic Islets and Subcellular Membranes: Comparison to Other Tissues and Implications for Membrane Fusion in Insulin Exocytosis †

    Sasanka Ramanadham;Fong-Fu Hsu;Alan Bohrer;William Nowatzke

  • Studies of Insulin Secretory Responses and of Arachidonic Acid Incorporation into Phospholipids of Stably Transfected Insulinoma Cells That Overexpress Group VIA Phospholipase A2(iPLA2β) Indicate a Signaling Rather Than a Housekeeping Role for iPLA2β

    Zhongmin Ma;Sasanka Ramanadham;Mary Wohltmann;Alan Bohrer

Frequent Co-Authors

John Turk
John Turk Washington University in St. Louis
Fong-Fu Hsu
Fong-Fu Hsu Washington University in St. Louis
Richard W. Gross
Richard W. Gross Washington University in St. Louis
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Evelina Gatti
Evelina Gatti Aix-Marseille University
Kevin E. Yarasheski
Kevin E. Yarasheski Washington University in St. Louis
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University
Maurizio Molinari
Maurizio Molinari Universita della Svizzera Italiana
Charles E. Chalfant
Charles E. Chalfant Virginia Commonwealth University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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