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Chemistry

D-Index
43
Citations
7219
World Ranking
17184
National Ranking
84

Overview

George Kokotos is affiliated with the National and Kapodistrian University of Athens in Greece. Their research spans multiple areas within biochemistry, genetics, molecular biology, and chemistry, with a significant focus on organic chemistry and molecular biology.

Their publication record includes research contributions in various scientific journals. Recent papers include:

  • Light-promoted oxidation of aldehydes to carboxylic acids under aerobic and photocatalyst-free conditions (2022, Green Chemistry)
  • Saturated Oxo Fatty Acids (SOFAs): A Previously Unrecognized Class of Endogenous Bioactive Lipids Exhibiting a Cell Growth Inhibitory Activity (2021, Journal of Medicinal Chemistry)
  • The design and discovery of phospholipase A2 inhibitors for the treatment of inflammatory diseases (2021, Expert Opinion on Drug Discovery)
  • A Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) Method for the Determination of Free Hydroxy Fatty Acids in Cow and Goat Milk (2020, Molecules)
  • Lipid mediators and biomarkers associated with type 1 diabetes development (2020, JCI Insight)

Frequent co-authors collaborating with George Kokotos include:

  • Christiana Mantzourani
  • Maroula G. Kokotou
  • Olga G. Mountanea
  • Christoforos G. Kokotos
  • Charikleia S. Batsika

George Kokotos's work is often published in key scientific venues such as:

  • Biomolecules
  • Molecules
  • European Journal of Organic Chemistry
  • Journal of Medicinal Chemistry
  • Chemistry - A European Journal

The scientific fields of study connected to their work primarily include:

  • Biochemistry, Genetics and Molecular Biology
  • Chemistry

Within these, their research delves into subfields such as:

  • Organic Chemistry
  • Molecular Biology
  • Biochemistry
  • Nutrition and Dietetics
  • Animal Science and Zoology

The main topics covered by George Kokotos across recent publications are:

  • Radical Photochemical Reactions
  • Eicosanoids and Hypertension Pharmacology
  • Chemical Synthesis and Reactions
  • Fatty Acid Research and Health
  • Meat and Animal Product Quality
  • Peroxisome Proliferator-Activated Receptors
  • Histone Deacetylase Inhibitors Research

Best Publications

  • Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

    Edward A. Dennis;Jian Cao;Yuan-Hao Hsu;Victoria Magrioti

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6.

    Arduino A. Mangoni;Catherine Guillou;Jean Jacques Vanden Eynde;Christopher Hulme

  • Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages.

    Luis Gil-de-Gómez;Alma M. Astudillo;Carlos Guijas;Victoria Magrioti

  • Synthetic and natural inhibitors of phospholipases A2: their importance for understanding and treatment of neurological disorders.

    Wei-Yi Ong;Tahira Farooqui;George Kokotos;Akhlaq A. Farooqui

  • A convenient one-pot conversion of N-protected amino acids and peptides into alcohols

    George Kokotos

  • Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.

    Efrosini Barbayianni;Eleanna Kaffe;Vassilis Aidinis;George Kokotos

  • Enantiospecific synthesis of α-amino acid semialdehydes: a key step for the synthesis of unnatural unsaturated and saturated α-amino acids

    José M Padrón;George Kokotos;Tomás Martı́n;Theodoros Markidis

  • A General Approach to the Asymmetric Synthesis of Unsaturated Lipidic α-Amino Acids. the First Synthesis of α-Aminoarachidonic Acid

    George Kokotos;José M. Padrón;Tomás Martín;Williams A. Gibbons

  • Selective One-Pot Conversion of Carboxylic Acids into Alcohols

    George Kokotos;Caterina Noula

  • Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo.

    George Kokotos;David A. Six;Vassilios Loukas;Timothy Smith

  • Potent and Selective Fluoroketone Inhibitors of Group VIA Calcium-Independent Phospholipase A2

    George Kokotos;Yuan-Hao Hsu;John E. Burke;Constantinos Baskakis

  • Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2

    George Kokotos;Stavroula Kotsovolou;David A. Six;Violetta Constantinou-Kokotou

  • Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2

    Aikaterini Nikolaou;Maroula G. Kokotou;Sofia Vasilakaki;George Kokotos

  • Prolinamides Bearing Thiourea Groups as Catalysts for Asymmetric Aldol Reactions

    Stamatis Fotaras;Christoforos G. Kokotos;Evaggelia Tsandi;George Kokotos

  • 4-Substituted prolines as organocatalysts for aldol reactions

    Evagelos Bellis;George Kokotos

  • Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2.

    David A Six;Efrosini Barbayianni;Vassilios Loukas;Violetta Constantinou-Kokotou

  • Synthesis and study of a lipophilic alpha-keto amide inhibitor of pancreatic lipase.

    Antonia Chiou;Theodoros Markidis;Violetta Constantinou-Kokotou;Robert Verger

  • Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

    Constantinos Baskakis;Victoria Magrioti;Naomi Cotton;Daren Stephens

  • Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry.

    John E. Burke;Arneh Babakhani;Alemayehu A. Gorfe;George Kokotos

  • Sulfonamides of homoproline and dipeptides as organocatalysts for Michael and aldol reactions

    Evaggelia Tsandi;Christoforos G. Kokotos;Sofia Kousidou;Valentine Ragoussis

  • Systemic and intrathecal effects of a novel series of phospholipase a2 inhibitors on hyperalgesia and spinal pge2 release

    Edward Dennis;Tony Yaksh;Karin Killerman Lucas;Camilla Svensson

Frequent Co-Authors

Edward A. Dennis
Edward A. Dennis University of California, San Diego
Christoforos G. Kokotos
Christoforos G. Kokotos National and Kapodistrian University of Athens
Uwe T. Bornscheuer
Uwe T. Bornscheuer University of Greifswald
Dimitra Hadjipavlou-Litina
Dimitra Hadjipavlou-Litina Aristotle University of Thessaloniki
Godefridus J. Peters
Godefridus J. Peters Gdańsk Medical University
Robert Verger
Robert Verger Centre national de la recherche scientifique, CNRS
María A. Balboa
María A. Balboa Spanish National Research Council
Sasanka Ramanadham
Sasanka Ramanadham University of Alabama at Birmingham
J. Andrew McCammon
J. Andrew McCammon University of California, San Diego
Pierre F. Ray
Pierre F. Ray Grenoble Alpes University

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