World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
28038
World Ranking
3829
National Ranking
1895

Overview

Christina S. Leslie is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focuses on the intersections of biochemistry, genetics, molecular biology, immunology, and microbiology. The scientist's work covers various subfields including molecular biology, immunology, oncology, cancer research, and genetics.

The main topics of their research include:

  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • RNA Research and Splicing
  • T-cell and B-cell Immunology
  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Single-cell and spatial transcriptomics

Their recent publications highlight contributions to cancer biology, immunology, and genetic mechanisms. Notable papers include:

  • "Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy," 2021, Cancer Cell
  • "Artificial intelligence in cancer research, diagnosis and therapy," 2021, Nature Reviews Cancer
  • "ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer," 2020, Nature Genetics
  • "Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota," 2022, Nature
  • "An epigenetic barrier sets the timing of human neuronal maturation," 2024, Nature

Frequent co-authors in Christina Leslie's research include:

  • Alexander Y. Rudensky
  • Yuri Pritykin
  • Merve Şahin
  • Michael G. Kharas
  • Wilfred Wong

The scientist publishes regularly in several high-profile and peer-reviewed venues. Key publication platforms are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cancer Research
  • Nature Genetics
  • Nature

Christina S. Leslie's research encompasses large data-driven approaches such as single-cell and spatial transcriptomics. They explore molecular and cellular mechanisms underlying cancer and immune system functions. Their work involves analysis of RNA biology, chromatin dynamics, and genetic engineering techniques including CRISPR, contributing to a multidisciplinary understanding of cancer and immunology.

Best Publications

  • CSF-1R inhibition alters macrophage polarization and blocks glioma progression

    Stephanie M Pyonteck;Leila Akkari;Alberto J Schuhmacher;Robert L Bowman

  • The spectrum kernel: a string kernel for SVM protein classification.

    Christina S. Leslie;Eleazar Eskin;William Stafford Noble

  • Mismatch string kernels for discriminative protein classification

    Christina S. Leslie;Eleazar Eskin;Adiel Cohen;Jason Weston

  • Chromatin states define tumour-specific T cell dysfunction and reprogramming

    Mary Philip;Lauren Fairchild;Lauren Fairchild;Liping Sun;Ellen L. Horste

  • Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

    Min Peng;Na Yin;Sagar Chhangawala;Ke Xu

  • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

    Aly A Khan;Doron Betel;Martin L Miller;Martin L Miller;Chris Sander

  • Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

    Robert M. Samstein;Aaron Arvey;Steven Z. Josefowicz;Xiao Peng

  • Transcription factor Foxp3 and its protein partners form a complex regulatory network

    Dipayan Rudra;Paul deRoos;Ashutosh Chaudhry;Rachel E Niec

  • ILC1 Confer Early Host Protection at Initial Sites of Viral Infection

    Orr El Weizman;Nicholas M. Adams;Iona S. Schuster;Chirag Krishna

  • Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.

    Chrysothemis C. Brown;Chrysothemis C. Brown;Herman Gudjonson;Yuri Pritykin;Deeksha Deep

  • Ubiquitously transcribed genes use alternative polyadenylation to achieve tissue-specific expression

    Steve Lianoglou;Steve Lianoglou;Vidur Garg;Julie L. Yang;Christina S. Leslie

  • Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

    Konstantinos J. Mavrakis;Andrew L. Wolfe;Andrew L. Wolfe;Elisa Oricchio;Teresa Palomero

  • Target mRNA abundance dilutes microRNA and siRNA activity

    Aaron Arvey;Erik Larsson;Chris Sander;Christina S Leslie

  • Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

    Gabriel B. Loeb;Aly A. Khan;Aly A. Khan;David Canner;Joseph B. Hiatt

  • Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

    Lisa Sevenich;Robert L. Bowman;Steven D. Mason;Daniela F. Quail

  • Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells

    Eirini P Papapetrou;Gabsang Lee;Nirav Malani;Manu Setty

  • Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

    Saïda Dadi;Sagar Chhangawala;Sagar Chhangawala;Benjamin M. Whitlock;Benjamin M. Whitlock;Ruth A. Franklin;Ruth A. Franklin

  • Ibrutinib Resistance in Chronic Lymphocytic Leukemia

    Richard R. Furman;Shuhua Cheng;Pin Lu;Menu Setty

  • Profile-based string kernels for remote homology detection and motif extraction.

    Rui Kuang;Eugene Ie;Ke Wang;Kai Wang

  • Mismatch String Kernels for SVM Protein Classification

    Eleazar Eskin;Jason Weston;William S. Noble;Christina S. Leslie

Frequent Co-Authors

William Stafford Noble
William Stafford Noble University of Washington
Michael H. Gelb
Michael H. Gelb University of Washington
Alexander Y. Rudensky
Alexander Y. Rudensky Memorial Sloan Kettering Cancer Center
Jason Weston
Jason Weston Facebook (United States)
Robert C. Murphy
Robert C. Murphy University of Colorado Denver
Anshul Kundaje
Anshul Kundaje Stanford University
Joseph V. Bonventre
Joseph V. Bonventre Brigham and Women's Hospital
Christopher J. Lengner
Christopher J. Lengner University of Pennsylvania
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Scott A. Armstrong
Scott A. Armstrong Harvard University

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