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Christopher J. Lengner

Christopher J. Lengner

University of Pennsylvania
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
16828
World Ranking
12970
National Ranking
5528

Christopher J. Lengner publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Christopher J. Lengner sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 145 publications — 24th percentile

24% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Christopher J. Lengner D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Christopher J. Lengner sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 58 D-Index — 34th percentile

34% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Christopher J. Lengner is affiliated with the University of Pennsylvania in the United States. Their research spans biochemistry, genetics, and molecular biology with a key focus on oncology and medicine.

Their work extensively covers subfields such as molecular biology, oncology, cancer research, genetics, and immunology. Primary topics of investigation include cancer cells and metastasis, single-cell and spatial transcriptomics, cancer genomics and diagnostics, epigenetics and DNA methylation, colorectal cancer treatments and studies, cancer-related molecular mechanisms, and Wnt/β-catenin signaling in development and cancer.

Lengner has contributed to multiple papers with notable examples including:

  • Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states, 2021, Cancer Cell
  • β-Hydroxybutyrate suppresses colorectal cancer, 2022, Nature
  • Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway, 2021, Nature Communications
  • BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells, 2020, Cell Reports
  • The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease, 2020, Cell Research

Frequent coauthors collaborating with Lengner include:

  • Zvi Cramer
  • Yuhua Tian
  • Ning Li
  • Anil K. Rustgi
  • Kathryn E. Hamilton

Their research has been published regularly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Cellular and Molecular Gastroenterology and Hepatology
  • Molecular Psychiatry

Throughout their career, Lengner has contributed primarily to advancing the understanding of molecular and cellular mechanisms underlying cancer progression and treatment resistance. The integration of lineage tracing, signaling pathways, and metabolic reprogramming feature prominently in their investigations.

Best Publications

  • Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

    Tripti Gaur;Christopher J. Lengner;Hayk Hovhannisyan;Ramesh A. Bhat

  • Direct cell reprogramming is a stochastic process amenable to acceleration

    Jacob Hanna;Krishanu Saha;Bernardo Pando;Jeroen van Zon

  • Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

    Jacob Hanna;Styliani Markoulaki;Patrick Schorderet;Bryce W. Carey

  • Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells

    Tobias Brambrink;Ruth K. Foreman;G. Grant Welstead;Christopher Joachim Lengner

  • Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

    Jacob Hanna;Albert W. Cheng;Krishanu Saha;Jongpil Kim

  • A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

    Marius Wernig;Christopher J. Lengner;Jacob Hanna;Michael A. Lodato

  • Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

    Jane B. Lian;Amjad Javed;S. Kaleem Zaidi;Christopher Lengner

  • Networks and hubs for the transcriptional control of osteoblastogenesis

    Jane B. Lian;Gary S. Stein;Amjad Javed;Andre J. Van Wijnen

  • Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal

    Christopher J. Lengner;Fernando D. Camargo;Konrad Hochedlinger;G. Grant Welstead

  • Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

    Christopher J. Lengner;Alexander A. Gimelbrant;Jennifer A. Erwin;Jennifer A. Erwin;Albert Wu Cheng

  • Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

    Michael G Kharas;Michael G Kharas;Christopher J Lengner;Fatima Al-Shahrour;Fatima Al-Shahrour;Lars Bullinger

  • Metastable Pluripotent States in NOD-Mouse-Derived ESCs

    Jacob Hanna;Styliani Markoulaki;Maisam Mitalipova;Albert W. Cheng

  • Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

    Jongpil Kim;Susan C. Su;Susan C. Su;Haoyi Wang;Albert W. Cheng

  • Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.

    Hongwon Kim;Hyeok Ju Park;Hwan Choi;Yujung Chang

  • Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling

    Christopher J. Lengner;Heather Anne Steinman;James Gagnon;Thomas W. Smith

  • DNA damage-induced type I interferon promotes senescence and inhibits stem cell function

    Qiujing Yu;Yuliya V. Katlinskaya;Christopher J. Carbone;Bin Zhao

  • Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states.

    Kamen P. Simeonov;China N. Byrns;Megan L. Clark;Robert J. Norgard

  • In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease

    Hanseul Park;Jungju Oh;Gayong Shim;Byounggook Cho

  • MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.

    Yuhua Tian;Jiuzhi Xu;Yuan Li;Ran Zhao

  • Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

    Sun-Mi Park;Raquel P. Deering;Yuheng Lu;Patrick Tivnan

Frequent Co-Authors

Jane B. Lian
Jane B. Lian University of Vermont
Gary S. Stein
Gary S. Stein University of Vermont
Janet L. Stein
Janet L. Stein University of Vermont
Rudolf Jaenisch
Rudolf Jaenisch MIT
Andre J. Van Wijnen
Andre J. Van Wijnen University of Connecticut Health Center
Jacob H. Hanna
Jacob H. Hanna Weizmann Institute of Science
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Amjad Javed
Amjad Javed University of Alabama at Birmingham
Christina S. Leslie
Christina S. Leslie Memorial Sloan Kettering Cancer Center
Fatima Al-Shahrour
Fatima Al-Shahrour Spanish National Cancer Research Centre

External Links

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Best Scientists Citing Christopher J. Lengner

Gary S. Stein

Gary S. Stein

University of Vermont

Publications: 133

Jane B. Lian

Jane B. Lian

University of Vermont

Publications: 109

Janet L. Stein

Janet L. Stein

University of Vermont

Publications: 97

Hans R. Schöler

Hans R. Schöler

Max Planck Society

Publications: 71

Andre J. Van Wijnen

Andre J. Van Wijnen

University of Connecticut Health Center

Publications: 66

Shinya Yamanaka

Shinya Yamanaka

Kyoto University

Publications: 61

Rudolf Jaenisch

Rudolf Jaenisch

MIT

Publications: 61

Konrad Hochedlinger

Konrad Hochedlinger

Harvard University

Publications: 53

Alexander Meissner

Alexander Meissner

Max Planck Institute for Molecular Genetics

Publications: 43

Pierre J. Marie

Pierre J. Marie

Centre national de la recherche scientifique, CNRS

Publications: 42

Jacob H. Hanna

Jacob H. Hanna

Weizmann Institute of Science

Publications: 41

Martin Montecino

Martin Montecino

Andrés Bello University

Publications: 40

George Q. Daley

George Q. Daley

Boston Children's Hospital

Publications: 37

Amjad Javed

Amjad Javed

University of Alabama at Birmingham

Publications: 33

Shaorong Gao

Shaorong Gao

Tongji University

Publications: 32

Marius Wernig

Marius Wernig

Stanford University

Publications: 29

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