D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 11,424 86 World Ranking 14482 National Ranking 6091

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cancer

Christopher J. Lengner mostly deals with Cell biology, Cellular differentiation, Reprogramming, Stem cell and Induced pluripotent stem cell. Many of his studies on Cell biology involve topics that are commonly interrelated, such as Genetics. His research integrates issues of Cancer research, Myeloid leukemia, RUNX2, Musashi2 and Regulation of gene expression in his study of Cellular differentiation.

His Reprogramming research incorporates themes from Ectopic expression and Somatic cell. His study looks at the intersection of Stem cell and topics like Molecular biology with Rex1 and Transgene. Christopher J. Lengner works mostly in the field of Induced pluripotent stem cell, limiting it down to topics relating to SOX2 and, in certain cases, Homeobox protein NANOG.

His most cited work include:

  • Direct cell reprogramming is a stochastic process amenable to acceleration (852 citations)
  • Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression (829 citations)
  • Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency (793 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Stem cell, Cancer research, Molecular biology and Cellular differentiation. His Cell biology study combines topics from a wide range of disciplines, such as Reprogramming, Embryonic stem cell and Genetics. The various areas that Christopher J. Lengner examines in his Reprogramming study include Transgene, Somatic cell, Neuron, Ectopic expression and Induced pluripotent stem cell.

His studies in Stem cell integrate themes in fields like Myeloid leukemia, Immunology and Intestinal epithelium. His Molecular biology research incorporates elements of RUNX2, Transcription factor, Gene expression, Immunofluorescence and Epitope. Christopher J. Lengner has included themes like NUMB, Endocrinology, Internal medicine and Notch signaling pathway in his Cellular differentiation study.

He most often published in these fields:

  • Cell biology (66.39%)
  • Stem cell (42.62%)
  • Cancer research (18.85%)

What were the highlights of his more recent work (between 2018-2021)?

  • Cell biology (66.39%)
  • Stem cell (42.62%)
  • Cancer research (18.85%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cell biology, Stem cell, Cancer research, Regeneration and Intestinal epithelium. While the research belongs to areas of Cell biology, he spends his time largely on the problem of Cell cycle, intersecting his research to questions surrounding Protein kinase B. Christopher J. Lengner focuses mostly in the field of Stem cell, narrowing it down to matters related to mTORC1 and, in some cases, Developmental cell.

His Cancer research research is multidisciplinary, relying on both Phenotype, Bleomycin, Carcinogenesis and mir-31. His Regeneration study incorporates themes from Telomere, Dyskeratosis congenita, Senescence and LGR5. His Intestinal epithelium research includes elements of Crypt, DNA damage, Homeostasis and Ulcerative colitis.

Between 2018 and 2021, his most popular works were:

  • Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids. (70 citations)
  • In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease (48 citations)
  • MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. (39 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Cancer

Christopher J. Lengner mainly investigates Cell biology, Neuroscience, Disease, Intestinal epithelium and Stem cell. Christopher J. Lengner combines subjects such as Cell, Cell cycle, NFAT, B cell and breakpoint cluster region with his study of Cell biology. The concepts of his Neuroscience study are interwoven with issues in Amyloid beta, Genome editing, CRISPR, Transgene and In vivo.

Christopher J. Lengner has researched Disease in several fields, including Mutation and Organoid. His biological study spans a wide range of topics, including DNA damage, Homeostasis, Radioresistance, Regeneration and Crypt. Christopher J. Lengner studies Stem cell, focusing on LGR5 in particular.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

Tripti Gaur;Christopher J. Lengner;Hayk Hovhannisyan;Ramesh A. Bhat.
Journal of Biological Chemistry (2005)

1160 Citations

Direct cell reprogramming is a stochastic process amenable to acceleration

Jacob Hanna;Krishanu Saha;Bernardo Pando;Jeroen van Zon.
Nature (2009)

1081 Citations

Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

Jacob Hanna;Styliani Markoulaki;Patrick Schorderet;Bryce W. Carey.
Cell (2008)

1060 Citations

Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells

Tobias Brambrink;Ruth K. Foreman;G. Grant Welstead;Christopher Joachim Lengner.
Cell Stem Cell (2008)

989 Citations

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

Jacob Hanna;Albert W. Cheng;Krishanu Saha;Jongpil Kim.
Proceedings of the National Academy of Sciences of the United States of America (2010)

894 Citations

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

Marius Wernig;Christopher J. Lengner;Jacob Hanna;Michael A. Lodato.
Nature Biotechnology (2008)

522 Citations

Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

Jane B. Lian;Amjad Javed;S. Kaleem Zaidi;Christopher Lengner.
Critical Reviews in Eukaryotic Gene Expression (2004)

521 Citations

Networks and hubs for the transcriptional control of osteoblastogenesis

Jane B. Lian;Gary S. Stein;Amjad Javed;Andre J. Van Wijnen.
Reviews in Endocrine & Metabolic Disorders (2006)

471 Citations

Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal

Christopher J. Lengner;Fernando D. Camargo;Konrad Hochedlinger;G. Grant Welstead.
Cell Stem Cell (2007)

449 Citations

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

Christopher J. Lengner;Alexander A. Gimelbrant;Jennifer A. Erwin;Jennifer A. Erwin;Albert Wu Cheng.
Cell (2010)

397 Citations

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Best Scientists Citing Christopher J. Lengner

Gary S. Stein

Gary S. Stein

University of Vermont

Publications: 133

Jane B. Lian

Jane B. Lian

University of Vermont

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Janet L. Stein

Janet L. Stein

University of Vermont

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Hans R. Schöler

Hans R. Schöler

Max Planck Society

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Andre J. Van Wijnen

Andre J. Van Wijnen

University of Massachusetts Medical School

Publications: 66

Rudolf Jaenisch

Rudolf Jaenisch

MIT

Publications: 61

Shinya Yamanaka

Shinya Yamanaka

Kyoto University

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Konrad Hochedlinger

Konrad Hochedlinger

Harvard University

Publications: 53

Alexander Meissner

Alexander Meissner

Max Planck Institute for Molecular Genetics

Publications: 43

Pierre J. Marie

Pierre J. Marie

Inserm : Institut national de la santé et de la recherche médicale

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Jacob H. Hanna

Jacob H. Hanna

Weizmann Institute of Science

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Martin Montecino

Martin Montecino

Andrés Bello University

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George Q. Daley

George Q. Daley

Boston Children's Hospital

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Amjad Javed

Amjad Javed

University of Alabama at Birmingham

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Shaorong Gao

Shaorong Gao

Tongji University

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Andras Nagy

Andras Nagy

Lunenfeld-Tanenbaum Research Institute

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