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Christopher J. Lengner

Christopher J. Lengner

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
16828
World Ranking
12970
National Ranking
5528

Overview

Christopher J. Lengner is affiliated with the University of Pennsylvania in the United States. Their research spans biochemistry, genetics, and molecular biology with a key focus on oncology and medicine.

Their work extensively covers subfields such as molecular biology, oncology, cancer research, genetics, and immunology. Primary topics of investigation include cancer cells and metastasis, single-cell and spatial transcriptomics, cancer genomics and diagnostics, epigenetics and DNA methylation, colorectal cancer treatments and studies, cancer-related molecular mechanisms, and Wnt/β-catenin signaling in development and cancer.

Lengner has contributed to multiple papers with notable examples including:

  • Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states, 2021, Cancer Cell
  • β-Hydroxybutyrate suppresses colorectal cancer, 2022, Nature
  • Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway, 2021, Nature Communications
  • BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells, 2020, Cell Reports
  • The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease, 2020, Cell Research

Frequent coauthors collaborating with Lengner include:

  • Zvi Cramer
  • Yuhua Tian
  • Ning Li
  • Anil K. Rustgi
  • Kathryn E. Hamilton

Their research has been published regularly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Cellular and Molecular Gastroenterology and Hepatology
  • Molecular Psychiatry

Throughout their career, Lengner has contributed primarily to advancing the understanding of molecular and cellular mechanisms underlying cancer progression and treatment resistance. The integration of lineage tracing, signaling pathways, and metabolic reprogramming feature prominently in their investigations.

Best Publications

  • Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

    Tripti Gaur;Christopher J. Lengner;Hayk Hovhannisyan;Ramesh A. Bhat

  • Direct cell reprogramming is a stochastic process amenable to acceleration

    Jacob Hanna;Krishanu Saha;Bernardo Pando;Jeroen van Zon

  • Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

    Jacob Hanna;Styliani Markoulaki;Patrick Schorderet;Bryce W. Carey

  • Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells

    Tobias Brambrink;Ruth K. Foreman;G. Grant Welstead;Christopher Joachim Lengner

  • Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

    Jacob Hanna;Albert W. Cheng;Krishanu Saha;Jongpil Kim

  • A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types

    Marius Wernig;Christopher J. Lengner;Jacob Hanna;Michael A. Lodato

  • Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

    Jane B. Lian;Amjad Javed;S. Kaleem Zaidi;Christopher Lengner

  • Networks and hubs for the transcriptional control of osteoblastogenesis

    Jane B. Lian;Gary S. Stein;Amjad Javed;Andre J. Van Wijnen

  • Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal

    Christopher J. Lengner;Fernando D. Camargo;Konrad Hochedlinger;G. Grant Welstead

  • Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

    Christopher J. Lengner;Alexander A. Gimelbrant;Jennifer A. Erwin;Jennifer A. Erwin;Albert Wu Cheng

  • Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

    Michael G Kharas;Michael G Kharas;Christopher J Lengner;Fatima Al-Shahrour;Fatima Al-Shahrour;Lars Bullinger

  • Metastable Pluripotent States in NOD-Mouse-Derived ESCs

    Jacob Hanna;Styliani Markoulaki;Maisam Mitalipova;Albert W. Cheng

  • Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

    Jongpil Kim;Susan C. Su;Susan C. Su;Haoyi Wang;Albert W. Cheng

  • Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids.

    Hongwon Kim;Hyeok Ju Park;Hwan Choi;Yujung Chang

  • Osteoblast differentiation and skeletal development are regulated by Mdm2–p53 signaling

    Christopher J. Lengner;Heather Anne Steinman;James Gagnon;Thomas W. Smith

  • DNA damage-induced type I interferon promotes senescence and inhibits stem cell function

    Qiujing Yu;Yuliya V. Katlinskaya;Christopher J. Carbone;Bin Zhao

  • Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states.

    Kamen P. Simeonov;China N. Byrns;Megan L. Clark;Robert J. Norgard

  • In vivo neuronal gene editing via CRISPR-Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer's disease

    Hanseul Park;Jungju Oh;Gayong Shim;Byounggook Cho

  • MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice.

    Yuhua Tian;Jiuzhi Xu;Yuan Li;Ran Zhao

  • Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs

    Sun-Mi Park;Raquel P. Deering;Yuheng Lu;Patrick Tivnan

Frequent Co-Authors

Jane B. Lian
Jane B. Lian University of Vermont
Gary S. Stein
Gary S. Stein University of Vermont
Janet L. Stein
Janet L. Stein University of Vermont
Andre J. Van Wijnen
Andre J. Van Wijnen University of Connecticut Health Center
Jacob H. Hanna
Jacob H. Hanna Weizmann Institute of Science
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Amjad Javed
Amjad Javed University of Alabama at Birmingham
Christina S. Leslie
Christina S. Leslie Memorial Sloan Kettering Cancer Center
Fatima Al-Shahrour
Fatima Al-Shahrour Spanish National Cancer Research Centre

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