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D-Index & Metrics

Molecular Biology

D-Index
52
Citations
14032
World Ranking
2414
National Ranking
1190

Overview

Amjad Javed is affiliated with the University of Alabama at Birmingham in the United States. Their research focuses primarily on medicine and biochemistry, genetics, and molecular biology, with specific expertise in several subfields including molecular biology, oncology, hematology, rheumatology, and cancer research.

The scientist's work covers multiple key topics within biomedical research. These include:

  • Bone Metabolism and Diseases
  • Multiple Myeloma Research and Treatments
  • Protease and Inhibitor Mechanisms
  • Osteoarthritis Treatment and Mechanisms
  • TGF-β signaling in diseases
  • Ubiquitin and proteasome pathways
  • Bone health and treatments

Significant recent papers published by Amjad Javed include:

  • "Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification," 2021, published in Matrix Biology Plus
  • "Runx2 Deficiency in Osteoblasts Promotes Myeloma Progression by Altering the Bone Microenvironment at New Bone Sites," 2020, published in Cancer Research
  • "Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Increasing TSP-1-Dependent TGFβ1 Activation and Suppressing Immunity in Bone Marrow," 2021, published in Molecular Cancer Therapeutics
  • "Runx2 deletion in hypertrophic chondrocytes impairs osteoclast mediated bone resorption," 2024, published in Bone
  • "Loss of early B cell protein λ5 decreases bone mass and accelerates skeletal aging," 2022, published in Frontiers in Immunology

Their frequent publication venues highlight a range of journals focused on immunology, cancer, and bone research including:

  • Frontiers in Immunology
  • Matrix Biology Plus
  • Cancer Research
  • Bone
  • Molecular Cancer Therapeutics

Amjad Javed collaborates consistently with other researchers in their field. Frequent co-authors include Harunur Rashid, Xiaoxuan Xu, Timothy N. Trotter, Mohamed Khass, and Peter D. Burrows. Each of these collaborations has contributed notably to their body of work, with four papers each involving these colleagues.

Best Publications

  • Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression

    Tripti Gaur;Christopher J. Lengner;Hayk Hovhannisyan;Ramesh A. Bhat

  • Oxidative Stress Induces Vascular Calcification Through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

    Chang Hyun Byon;Amjad Javed;Qun Dai;John C. Kappes

  • Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression.

    Gary S. Stein;Jane B. Lian;Andre J. Van Wijnen;Janet L. Stein

  • Regulatory controls for osteoblast growth and differentiation: role of Runx/Cbfa/AML factors

    Jane B. Lian;Amjad Javed;S. Kaleem Zaidi;Christopher Lengner

  • Networks and hubs for the transcriptional control of osteoblastogenesis

    Jane B. Lian;Gary S. Stein;Amjad Javed;Andre J. Van Wijnen

  • The Runx2 Osteogenic Transcription Factor Regulates Matrix Metalloproteinase 9 in Bone Metastatic Cancer Cells and Controls Cell Invasion

    Jitesh Pratap;Amjad Javed;Lucia R. Languino;Andre J. van Wijnen

  • Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation.

    Mi Hye Lee;Amjad Javed;Hyun Jung Kim;Hong In Shin

  • CCAAT/Enhancer-binding Proteins (C/EBP) β and δ Activate Osteocalcin Gene Transcription and Synergize with Runx2 at the C/EBP Element to Regulate Bone-specific Expression

    Soraya E. Gutierrez;Amjad Javed;Daniel K. Tennant;Monique van Rees

  • Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.

    J. Pratap;J. B. Lian;A. Javed;G. L. Barnes

  • Smooth Muscle Cell-Specific Runx2 Deficiency Inhibits Vascular Calcification

    Yong Sun;Chang Hyun Byon;Kaiyu Yuan;Jianfeng Chen

  • Dlx3 Transcriptional Regulation of Osteoblast Differentiation: Temporal Recruitment of Msx2, Dlx3, and Dlx5 Homeodomain Proteins to Chromatin of the Osteocalcin Gene

    Mohammad Q. Hassan;Amjad Javed;Maria I. Morasso;Jeremy Karlin

  • Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development.

    Je Yong Choi;Je Yong Choi;Jitesh Pratap;Amjad Javed;S. Kaleem Zaidi

  • Groucho/TLE/R-esp proteins associate with the nuclear matrix and repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of tissue-specific gene transcription

    A. Javed;B. Guo;S. Hiebert;J.Y. Choi

  • Differential Regulation of the Two Principal Runx2/Cbfa1 N-Terminal Isoforms in Response to Bone Morphogenetic Protein-2 during Development of the Osteoblast Phenotype

    Chaitali Banerjee;Amjad Javed;Je Yong Choi;Jack Green

  • Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2

    Daniel W. Young;Mohammad Q. Hassan;Jitesh Pratap;Mario Galindo;Mario Galindo

  • Cbfbeta interacts with Runx2 and has a critical role in bone development.

    Mondira Kundu;Amjad Javed;Jae-Pil Jeon;Alan Horner

  • Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

    Amjad Javed;George L. Barnes;Jitesh Pratap;Tomasz Antkowiak

  • Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts.

    Michelle Prince;Chaitali Banerjee;Amjad Javed;Jack Green

  • BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

    Mohammad Q. Hassan;Rahul S. Tare;Suk Hee Lee;Matthew Mandeville

  • runt Homology Domain Transcription Factors (Runx, Cbfa, and AML) Mediate Repression of the Bone Sialoprotein Promoter: Evidence for Promoter Context-Dependent Activity of Cbfa Proteins

    Amjad Javed;George L. Barnes;B. O. Jasanya;Janet L. Stein

Frequent Co-Authors

Gary S. Stein
Gary S. Stein University of Vermont
Jane B. Lian
Jane B. Lian University of Vermont
Janet L. Stein
Janet L. Stein University of Vermont
Andre J. Van Wijnen
Andre J. Van Wijnen University of Connecticut Health Center
Martin Montecino
Martin Montecino Andrés Bello University
Sayyed K. Zaidi
Sayyed K. Zaidi University of Vermont
Je-Yong Choi
Je-Yong Choi Kyungpook National University
Christopher J. Lengner
Christopher J. Lengner University of Pennsylvania
Louis C. Gerstenfeld
Louis C. Gerstenfeld Boston University
Jeffrey A. Nickerson
Jeffrey A. Nickerson University of Massachusetts Chan Medical School

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