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Toshihisa Komori

Toshihisa Komori

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
34484
World Ranking
3623
National Ranking
228

Overview

Toshihisa Komori is affiliated with Nagasaki University in Japan and has a robust research portfolio focused primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work is notably concentrated on molecular biology, oncology, rheumatology, orthopedics and sports medicine, and cancer research.

Their research extensively covers topics related to bone metabolism and diseases, as well as bone health and treatments. Additional key areas include bone health and osteoporosis research, osteoarthritis treatment and mechanisms, TGF-β signaling in diseases, inflammatory mediators and NSAID effects, and bone and dental protein studies.

Toshihisa Komori has authored numerous papers published across a variety of recognized scientific venues. Prominent journals featuring their work include the International Journal of Molecular Sciences, where they have published 12 papers, PLoS Genetics with 3 papers, Communications Biology also hosting 3 papers, Bone with 2 publications, and PubMed with 1 paper.

Some of their notable recent papers include:

  • Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle (2020, International Journal of Molecular Sciences)
  • Molecular Mechanism of Runx2-Dependent Bone Development (2020, PubMed)
  • Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass (2020, PLoS Genetics)
  • Whole Aspect of Runx2 Functions in Skeletal Development (2022, International Journal of Molecular Sciences)
  • Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts (2020, PLoS Genetics)

Their frequent collaborators include Takeshi Moriishi, Hisato Komori, Qing Jiang, Kosei Ito, and Yuki Matsuo, reflecting a collaborative approach to their scientific inquiries.

Best Publications

  • Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

    T Komori;H Yagi;S Nomura;A Yamaguchi

  • Regulation of osteoblast differentiation by transcription factors

    Toshihisa Komori

  • Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

    Kyeong-Sook Lee;Hyun-Jung Kim;Qing-Lin Li;Xin-Zi Chi

  • Pathogenic Significance of Interleukin-6 (IL-6/BSF-2) in Castleman's Disease

    K Yoshizaki;T Matsuda;N Nishimoto;T Kuritani

  • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1.

    Akira Yamaguchi;Toshihisa Komori;Tatsuo Suda

  • Regulation of bone development and extracellular matrix protein genes by RUNX2.

    Toshihisa Komori

  • Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

    Ichiro Taniuchi;Motomi Osato;Takeshi Egawa;Mary Jean Sunshine

  • Maturational disturbance of chondrocytes in Cbfa1-deficient mice.

    Masahiko Inada;Takahiro Yasui;Takahiro Yasui;Shintaro Nomura;Seigou Miyake

  • Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

    Carolina A. Yoshida;Hiromitsu Yamamoto;Takashi Fujita;Tatsuya Furuichi

  • Regulation of Proliferation, Differentiation and Functions of Osteoblasts by Runx2.

    Toshihisa Komori

  • Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures.

    Wenguang Liu;Satoru Toyosawa;Tatsuya Furuichi;Naoko Kanatani

  • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

    Takashi Fujita;Yasutaka Azuma;Ryo Fukuyama;Ryo Fukuyama;Yuji Hattori

  • Cbfa1 isoforms exert functional differences in osteoblast differentiation.

    Hideyuki Harada;Shuzo Tagashira;Masanori Fujiwara;Shinji Ogawa

  • Regulation of Osteoblast Differentiation by Runx2

    Toshihisa Komori

  • Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

    Koichi Sasaki;Hideshi Yagi;Roderick T. Bronson;Kumi Tominaga

  • Cbfa1 is a positive regulatory factor in chondrocyte maturation.

    Hirayuki Enomoto;Motomi Enomoto-Iwamoto;Masahiro Iwamoto;Shintaro Nomura

  • Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes

    Chisato Ueta;Masahiro Iwamoto;Naoko Kanatani;Carolina Yoshida

  • Regulation of skeletal development by the Runx family of transcription factors

    Toshihisa Komori

  • Runx2, an inducer of osteoblast and chondrocyte differentiation

    Toshihisa Komori

  • Runx2, a multifunctional transcription factor in skeletal development.

    Toshihisa Komori

Frequent Co-Authors

Akira Yamaguchi
Akira Yamaguchi Tokyo Dental College
Haruo Sugiyama
Haruo Sugiyama Osaka University
Masahiro Iwamoto
Masahiro Iwamoto University of Maryland, Baltimore
Motomi Enomoto-Iwamoto
Motomi Enomoto-Iwamoto University of Maryland, Baltimore
Tadamitsu Kishimoto
Tadamitsu Kishimoto Osaka University
Yoshiaki Ito
Yoshiaki Ito National University of Singapore
Masaki Noda
Masaki Noda Tokyo Medical and Dental University
Hiroshi Kawaguchi
Hiroshi Kawaguchi University of Tokyo
Motomi Osato
Motomi Osato National University of Singapore
Kunikazu Tsuji
Kunikazu Tsuji Tokyo Medical and Dental University

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