World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
43
Citations
8278
World Ranking
2967
National Ranking
17

Overview

Motomi Osato is affiliated with the National University of Singapore in Singapore. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a focus on subfields including Molecular Biology, Hematology, Immunology, Cancer Research, and Oncology.

Osato's work covers several main research topics:

  • Acute Myeloid Leukemia Research
  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Immune Cell Function and Interaction
  • RNA Research and Splicing
  • Protein Degradation and Inhibitors
  • RNA modifications and cancer

Their notable recent publications include:

  • "Independent origins of fetal liver haematopoietic stem and progenitor cells," 2022, published in Nature
  • "ZNF143 mediates CTCF-bound promoter-enhancer loops required for murine hematopoietic stem and progenitor cell function," 2021, published in Nature Communications
  • "High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform," 2023, published in Nature Communications
  • "Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance," 2020, published in Blood
  • "Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia," 2020, published in Blood

Frequent co-authors collaborating extensively with Osato are:

  • Daniel G. Tenen
  • Yoshiaki Ito
  • Tomomasa Yokomizo
  • Chelsia Qiuxia Wang
  • Henry Yang

Motomi Osato regularly publishes in several scientific venues, most notably:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gene
  • Nature Communications
  • The EMBO Journal

The scope of Osato's work integrates molecular mechanisms underlying hematopoietic stem cell function and maintenance, chromatin interaction dynamics, and genetic regulation relevant to leukemia and immunology. Their research output and collaborations indicate active involvement in advancing understanding within these interconnected biomedical domains.

Best Publications

  • Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

    Ichiro Taniuchi;Motomi Osato;Takeshi Egawa;Mary Jean Sunshine

  • Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias.

    Motomi Osato;Norio Asou;Norio Asou;Essam Abdalla;Koyu Hoshino;Koyu Hoshino

  • In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

    Joëlle Michaud;Feng Wu;Motomi Osato;Gregory M. Cottles

  • MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

    Cheryl M. Koh;Marco Bezzi;Diana H P Low;Wei X ia Ang

  • Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.

    Motomi Osato

  • Heterozygous PU.1 mutations are associated with acute myeloid leukemia

    Beatrice U. Mueller;Thomas Pabst;Motomi Osato;Norio Asou

  • RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis.

    Kosei Ito;Anthony Chee-Beng Lim;Manuel Salto-Tellez;Lena Motoda

  • Requirement of Runx1/AML1/PEBP2αB for the generation of haematopoietic cells from endothelial cells

    Tomomasa Yokomizo;Minetaro Ogawa;Motomi Osato;Tomohiko Kanno

  • Functional Analysis of RUNX2 Mutations in Japanese Patients with Cleidocranial Dysplasia Demonstrates Novel Genotype-Phenotype Correlations

    Taketoshi Yoshida;Hirokazu Kanegane;Motomi Osato;Masatoshi Yanagida

  • Integrative analysis of RUNX1 downstream pathways and target genes

    Joëlle Michaud;Joëlle Michaud;Joëlle Michaud;Ken M Simpson;Robert Escher;Robert Escher;Karine Buchet-Poyau

  • Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice

    Junichi Matsuo;Shunichi Kimura;Shunichi Kimura;Akihiro Yamamura;Akihiro Yamamura;Cai Ping Koh

  • Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis.

    Bindya Jacob;Bindya Jacob;Motomi Osato;Motomi Osato;Namiko Yamashita;Chelsia Qiuxia Wang

  • PRL-3 Initiates Tumor Angiogenesis by Recruiting Endothelial Cells In vitro and In vivo

    Ke Guo;Jie Li;Haihe Wang;Motomi Osato

  • A Runx1 intronic enhancer marks hemogenic endothelial cells and hematopoietic stem cells.

    Cherry Ee Lin Ng;Cherry Ee Lin Ng;Tomomasa Yokomizo;Namiko Yamashita;Branko Cirovic

  • Runx1 is involved in primitive erythropoiesis in the mouse.

    Tomomasa Yokomizo;Kazuteru Hasegawa;Hiroyuki Ishitobi;Motomi Osato

  • Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF-β1 and Retinoic Acid Signaling

    Kakeru Watanabe;Manabu Sugai;Yukiko Nambu;Motomi Osato;Motomi Osato

  • Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

    Chelsia Qiuxia Wang;Chelsia Qiuxia Wang;Vaidehi Krishnan;Lavina Sierra Tay;Desmond Wai Loon Chin

  • Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.

    Lena Motoda;Lena Motoda;Motomi Osato;Motomi Osato;Namiko Yamashita;Bindya Jacob

  • Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model

    Masayuki Iwasaki;Takeshi Kuwata;Yukari Yamazaki;Nancy A. Jenkins

  • Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult

    Motomi Osato;Lena Motoda;Namiko Yamashita;Bindya Jacob

Frequent Co-Authors

Yoshiaki Ito
Yoshiaki Ito National University of Singapore
Vinay Tergaonkar
Vinay Tergaonkar Agency for Science, Technology and Research
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Kiyoshi Takatsuki
Kiyoshi Takatsuki Kumamoto University
Toshio Suda
Toshio Suda National University of Singapore
Katsuya Shigesada
Katsuya Shigesada Kyoto University
Atsushi Iwama
Atsushi Iwama University of Tokyo
Wee Joo Chng
Wee Joo Chng National University of Singapore
Ichiro Taniuchi
Ichiro Taniuchi RIKEN Center for Integrative Medical Sciences
Yoshiaki Ito
Yoshiaki Ito Kyoto University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Molecular Biology in the USA can open doors to a wide range of exciting online degrees that complement and broaden your career opportunities. Students often consider interdisciplinary studies to connect biology with other fields. If you are looking for flexible and accessible education, exploring cheap online interdisciplinary studies degree options can help tailor your learning experience and reduce costs.

Analytical skills gained from molecular biology pair well with mathematics. Pursuing a bachelor in mathematics online can further enhance your data analysis and research capabilities. For those interested in the creative side of science communication, a graphic design degree online provides valuable skills for presenting scientific findings visually in educational materials and media.

Graduate study is another pathway to advanced careers. An online history master's degree can be a unique addition, giving you perspective on the development of science within different societies and improving your research profile. These options demonstrate how a background in molecular biology can connect with diverse educational paths and professional roles.

Best Scientists Citing Motomi Osato

Trending Scientists

Recently Published Articles