World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10943
World Ranking
16600
National Ranking
6869

Overview

John H. Bushweller is affiliated with the University of Virginia in the United States and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including molecular biology, hematology, oncology, epidemiology, and public health, environmental and occupational health.

The scientist's recent research has focused on critical topics such as acute myeloid leukemia research, protein degradation and inhibitors, cancer cells and metastasis, genomics and chromatin dynamics, epigenetics and DNA methylation, acute lymphoblastic leukemia research, and cancer-related molecular pathways.

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Journal of Molecular Biology, Science Advances, and Blood.

  • RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells (2020, Journal of Cellular Physiology)
  • TNF-α signaling regulates RUNX1 function in endothelial cells (2020, The FASEB Journal)
  • The Intrinsically Disordered Proteins MLLT3 (AF9) and MLLT1 (ENL) - Multimodal Transcriptional Switches With Roles in Normal Hematopoiesis, MLL Fusion Leukemia, and Kidney Cancer (2021, Journal of Molecular Biology)
  • KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer (2022, Science Advances)
  • BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity (2020, Blood Cancer Discovery)

John H. Bushweller has collaborated frequently with several co-authors, including Ashish Kabra, Adam Boulton, Julien Pedron, Peter Keane, and Paulynn Suyin Chin, reflecting a collaborative research approach across multiple studies.

Best Publications

  • Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

    W.-J. Song;M. G. Sullivan;R. D. Legare;S. Hutchings

  • The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

    Qing Wang;Terryl Stacy;Janelle D. Miller;Amy F. Lewis

  • Targeting transcription factors in cancer - from undruggable to reality.

    John H Bushweller

  • Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutinin.

    Xing Han;John H. Bushweller;David S. Cafiso;Lukas K. Tamm

  • Structure of outer membrane protein A transmembrane domain by NMR spectroscopy

    Ashish Arora;Frits Abildgaard;John H. Bushweller;Lukas K. Tamm

  • Structural and functional characterization of the mutant Escherichia coli glutaredoxin (C14.fwdarw.S) and its mixed disulfide with glutathione

    Bushweller Jh;Aslund F;Wüthrich K;Holmgren A

  • Site-directed parallel spin-labeling and paramagnetic relaxation enhancement in structure determination of membrane proteins by solution NMR spectroscopy.

    Binyong Liang;John H. Bushweller;Lukas K. Tamm

  • NMR Solution Structure of the Integral Membrane Enzyme DsbB: Functional Insights into DsbB-Catalyzed Disulfide Bond Formation

    Yunpeng Zhou;Tomasz Cierpicki;Ricardo H. Flores Jimenez;Stephen M. Lukasik

  • Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia

    Tomasz Cierpicki;Laurie E Risner;Laurie E Risner;Jolanta Grembecka;Stephen M Lukasik

  • Reduced dimensionality in triple-resonance NMR experiments

    T. Szyperski;G. Wider;J. H. Bushweller;K. Wuethrich

  • The Nuclear Magnetic Resonance Solution Structure of the Mixed Disulfide between Escherichia coli Glutaredoxin(C14S) and Glutathione

    John H. Bushweller;Martin Billeter;Arne Holmgren;Kurt Wüthrich

  • The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

    Yizhou Liu;Matthew D. Cheney;Justin J. Gaudet;Maksymilian Chruszcz

  • Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles

    Christina J. Matheny;Maren E. Speck;Patrick R. Cushing;Yunpeng Zhou

  • NMR structure of oxidized Escherichia coli glutaredoxin: comparison with reduced E. coli glutaredoxin and functionally related proteins.

    Tai-He Xia;John H. Bushweller;Patrick Sodano;Martin Billeter

  • The DCX-domain Tandems of Doublecortin and Doublecortin-like Kinase

    Myung Hee Kim;Tomasz Cierpicki;Tomasz Cierpicki;Urszula Derewenda;Daniel Krowarsch

  • Allosteric Inhibition of the Protein-Protein Interaction between the Leukemia-Associated Proteins Runx1 and CBFβ

    Michael J. Gorczynski;Jolanta Grembecka;Yunpeng Zhou;Yali Kong

  • Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity

    Yizhou Liu;Wei Chen;Justin Gaudet;Matthew D. Cheney

  • Sequence-specific 1H n.m.r. assignments and determination of the three-dimensional structure of reduced Escherichia coli glutaredoxin.

    Patrick Sodano;Tai-he Xia;John H. Bushweller;Olof Björnberg

  • MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

    Frank E. Erfurth;Relja Popovic;Jolanta Grembecka;Tomasz Cierpicki

  • The Ig fold of the core binding factor α Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains

    Marcelo J Berardi;Chaohong Sun;Michael Zehr;Frits Abildgaard

Frequent Co-Authors

Nancy A. Speck
Nancy A. Speck University of Pennsylvania
Zygmunt S. Derewenda
Zygmunt S. Derewenda University of Virginia
Kurt Wüthrich
Kurt Wüthrich ETH Zurich
David S. Cafiso
David S. Cafiso University of Virginia
Arne Holmgren
Arne Holmgren Karolinska Institute
Wladek Minor
Wladek Minor University of Virginia
Thomas M. Laue
Thomas M. Laue University of New Hampshire
Sayyed K. Zaidi
Sayyed K. Zaidi University of Vermont
Janet L. Stein
Janet L. Stein University of Vermont
Jane B. Lian
Jane B. Lian University of Vermont

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA opens doors to a wide range of career options, many of which offer flexible online pathways. For those interested in combining scientific expertise with leadership, pursuing one of the cheapest online mba healthcare programs can be a cost-effective way to access healthcare management roles. These programs blend scientific knowledge with business skills to prepare graduates for high-demand positions in hospital administration and healthcare consulting.

Another fast-growing area is medical coding and billing, which leverages a foundation in biology and medical terminology. Understanding the differences between ccs certification and other coding accreditations is crucial for anyone considering this field, as certification can impact job prospects and salary.

Compensation in this sector is competitive—learn how much does a medical coder make and whether this remote-friendly role suits your ambitions. The job outlook for medical billing and coding remains very strong due to increased demand for healthcare services and digital health record keeping.

Best Scientists Citing John H. Bushweller

Trending Scientists