Nancy A. Speck

Research.com Recognitions

• 2019 - Member of the National Academy of Sciences

Overview

Best Publications

• Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.

  Qing Wang;Terryl Stacy;Michael Binder;Miguel Marin-Padilla

  1765
  Citations

• Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

  W.-J. Song;M. G. Sullivan;R. D. Legare;S. Hutchings

  1255
  Citations

• Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

  Michael J. Chen;Tomomasa Yokomizo;Brandon M. Zeigler;Elaine Dzierzak

  1111
  Citations

• Of lineage and legacy: the development of mammalian hematopoietic stem cells

  Elaine Dzierzak;Nancy A Speck

  956
  Citations

• Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

  Marella F.T.R. de Bruijn;Nancy A. Speck;Marian C.E. Peeters;Elaine Dzierzak

  845
  Citations

• The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

  Qing Wang;Terryl Stacy;Janelle D. Miller;Amy F. Lewis

  795
  Citations

• Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

  Trista North;Ting-Lei Gu;Terryl Stacy;Qing Wang

  779
  Citations

• Core-binding factors in haematopoiesis and leukaemia.

  Nancy A. Speck;D. Gary Gilliland

  773
  Citations

• Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo

  Trista E North;Marella F.T.R de Bruijn;Terryl Stacy;Laleh Talebian

  668
  Citations

• Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor.

  Shuwen Wang;Qing Wang;Barbara E Crute;Irena N Melnikova

  640
  Citations

• Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype

  Joseph D. Growney;Hirokazu Shigematsu;Zhe Li;Benjamin H. Lee

  540
  Citations

• Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

  Donald A. Yergeau;Christopher J. Hetherington;Qing Wang;Pu Zhang

  516
  Citations

• Failure of Embryonic Hematopoiesis andLethal Hemorrhages in Mouse Embryos Heterozygousfor a Knocked-In Leukemia Gene CBFB–MYH11

  Lucio H Castilla;Cisca Wijmenga;Qing Wang;Terryl Stacy

  365
  Citations

• Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer.

  Nancy A. Speck;David Baltimore

  359
  Citations

• Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

  Owen J. Tamplin;Ellen M. Durand;Logan A. Carr;Sarah J. Childs

  357
  Citations

• Core-binding factors in hematopoiesis and immune function

  Marella F. T. R. De Bruijn;Nancy A. Speck

  342
  Citations

• Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

  Georges Lacaud;Lia Gore;Marion Kennedy;Valerie Kouskoff

  340
  Citations

• HUMAN DEFINITIVE HAEMOGENIC ENDOTHELIUM AND ARTERIAL VASCULAR ENDOTHELIUM REPRESENT DISTINCT LINEAGES

  Andrea Ditadi;Christopher M Sturgeon;Joanna Tober;Geneve Awong

  327
  Citations

• Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells

  Michael J. Chen;Yan Li;Maria Elena De Obaldia;Qi Yang

  293
  Citations

• PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

  Gang Huang;Pu Zhang;Hideyo Hirai;Hideyo Hirai;Shannon Elf

  289
  Citations