World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
42
Citations
9926
World Ranking
19454
National Ranking
7935

Overview

Trista E. North is affiliated with Boston Children's Hospital in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, North's work focuses on several subfields including Molecular Biology, Immunology, Cell Biology, Hematology, and Oncology.

The scientist's research topics encompass diverse areas such as Zebrafish Biomedical Research Applications, CAR-T cell therapy research, Single-cell and spatial transcriptomics, Acute Myeloid Leukemia Research, Phagocytosis and Immune Regulation, Immune Cell Function and Interaction, and Erythrocyte Function and Pathophysiology.

North has contributed to multiple publication venues with a frequent presence in Experimental Hematology, bioRxiv (Cold Spring Harbor Laboratory), Blood, Cell stem cell, and Developmental Cell.

Their notable recent papers include the following:

  • "YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow" (2020, Developmental Cell)
  • "EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity" (2022, Cell stem cell)
  • "Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production" (2020, Developmental Cell)
  • "Structural basis for inactivation of PRC2 by G-quadruplex RNA" (2023, Science)
  • "Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon" (2023, Cell stem cell)

Frequent co-authors in North's research include George Q. Daley, Edroaldo Lummertz da Rocha, Mohamad Najia, Caroline Kubaczka, and Thorsten M. Schlaeger.

Best Publications

  • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

    Trista E. North;Wolfram Goessling;Wolfram Goessling;Carl R. Walkley;Claudia Lengerke

  • The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

    Yingzi Wang;Andrei Krivtsov;Amit U. Sinha;Trista Elizabeth North;Trista Elizabeth North

  • Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.

    Wolfram Goessling;Trista E. North;Trista E. North;Sabine Loewer;Sabine Loewer;Allegra M. Lord;Allegra M. Lord

  • Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

    Trista North;Ting-Lei Gu;Terryl Stacy;Qing Wang

  • Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo

    Trista E North;Marella F.T.R de Bruijn;Terryl Stacy;Laleh Talebian

  • Hematopoietic Stem Cell Development Is Dependent on Blood Flow

    Trista E. North;Wolfram Goessling;Marian Peeters;Pulin Li

  • Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

    Corey Cutler;Pratik Multani;David Robbins;Haesook T. Kim

  • Prostaglandin E2 Enhances Human Cord Blood Stem Cell Xenotransplants and Shows Long-Term Safety in Preclinical Nonhuman Primate Transplant Models

    Wolfram Goessling;Robyn S. Allen;Xiao Guan;Ping Jin

  • Identification of small molecules for human hepatocyte expansion and iPS differentiation

    Jing Shan;Robert E Schwartz;Robert E Schwartz;Nathan T Ross;David J Logan

  • Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

    Yan Li;Virginie Esain;Li Teng;Jian Xu

  • APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.

    Wolfram Goessling;Trista E. North;Allegra M. Lord;Craig Ceol

  • PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

    Trista E. North;I. Ramesh Babu;Lea M. Vedder;Allegra M. Lord

  • Core-Binding Factor: A Central Player in Hematopoiesis and Leukemia

    Nancy A. Speck;Terry Stacy;Qing Wang;Trista North

  • New Waves of Discovery: Modeling Cancer in Zebrafish

    Wolfram Goessling;Trista E. North;Leonard I. Zon

  • Runx1 Is Expressed in Adult Mouse Hematopoietic Stem Cells and Differentiating Myeloid and Lymphoid Cells, But Not in Maturing Erythroid Cells

    Trista E. North;Terryl Stacy;Christina J. Matheny;Nancy A. Speck

  • Mutation mapping and identification by whole genome sequencing

    Ignaty Leshchiner;Kristen Alexa;Peter Kelsey;Ivan Adzhubei

  • Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production.

    Mauricio Cortes;Michael J. Chen;David L. Stachura;Sarah Y. Liu

  • Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo.

    James M. Harris;Virginie Esain;Gregory M. Frechette;Lauren J. Harris

  • Estrogen Activation of G-Protein–Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

    Saireudee Chaturantabut;Arkadi Shwartz;Kimberley J. Evason;Andrew G. Cox

  • Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors

    Wolfram Goessling;Trista E North;Leonard I Zon

Frequent Co-Authors

Wolfram Goessling
Wolfram Goessling Brigham and Women's Hospital
George Q. Daley
George Q. Daley Boston Children's Hospital
Leonard I. Zon
Leonard I. Zon Harvard University
Thorsten M. Schlaeger
Thorsten M. Schlaeger Boston Children's Hospital
Stuart H. Orkin
Stuart H. Orkin Harvard University
Barry H. Paw
Barry H. Paw Brigham and Women's Hospital
Nancy A. Speck
Nancy A. Speck University of Pennsylvania
Donald E. Ingber
Donald E. Ingber Harvard University

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