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Biology and Biochemistry

D-Index
78
Citations
20044
World Ranking
4588
National Ranking
2231

Overview

David A. Harris is affiliated with Boston University in the United States. Their research focuses primarily on biochemistry, genetics, molecular biology, and medicine, with significant contributions in molecular biology, neurology, physiology, nutrition and dietetics, as well as radiology, nuclear medicine, and imaging.

The scientist's work centers largely on prion diseases and protein misfolding, alongside neurological diseases and metabolism. Alzheimer's disease research and treatments are also important themes within their research, complemented by investigations into trace elements in health, monoclonal and polyclonal antibodies research, bacterial biofilms and quorum sensing, and Vibrio bacteria studies.

Notable recent publications include:

  • Both N-Terminal and C-Terminal Histidine Residues of the Prion Protein Are Essential for Copper Coordination and Neuroprotective Self-Regulation (2020, Journal of Molecular Biology)
  • Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers (2021, Nature Communications)
  • Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies (2021, Science Advances)
  • Mechanisms of prion-induced toxicity (2022, Cell and Tissue Research)
  • The prion protein and its ligands: Insights into structure-function relationships (2022, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research)

David A. Harris frequently collaborates with several researchers, including Robert C.C. Mercer, Nhat T. T. Le, Janelle S. Vultaggio, Bei Wu, and Glenn L. Millhauser.

The scientist has published widely in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, Journal of Molecular Biology, Nature Communications, and Science Advances.

In addition to journal publications, their academic output includes book publications, notably Failed Evidence (2020) released by New York University Press eBooks.

Best Publications

  • Copper Stimulates Endocytosis of the Prion Protein

    Peter C. Pauly;David A. Harris

  • SULFATED GLYCANS STIMULATE ENDOCYTOSIS OF THE CELLULAR ISOFORM OF THE PRION PROTEIN, PRPC, IN CULTURED CELLS

    Show Ling Shyng;Sylvain Lehmann;Krista L. Moulder;David A. Harris

  • The Cellular Prion Protein (PrPC): Its Physiological Function and Role in Disease

    Laura Westergard;Heather M. Christensen;David A. Harris

  • Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

    Matthew B. Rogers;James D. Hilley;Nicholas J. Dickens;Jon Wilkes

  • Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin.

    Alexander Gorodinsky;David A. Harris

  • A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells.

    Show-Ling Shyng;M. T. Huber;D. A. Harris

  • Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa.

    Craig Winstanley;Morgan G.I. Langille;Joanne L. Fothergill;Irena Kukavica-Ibrulj

  • Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

    Claudio Soto;Richard J Kascsak;Gabriela P Saborío;Pierre Aucouturier

  • NEUROLOGICAL ILLNESS IN TRANSGENIC MICE EXPRESSING A PRION PROTEIN WITH AN INSERTIONAL MUTATION

    R. Chiesa;P. Piccardo;B. Ghetti;D. A. Harris

  • A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.

    Show Ling Shyng;John E. Heuser;David A. Harris

  • Cellular Biology of Prion Diseases

    David A. Harris

  • Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein

    Noriyuki Nishida;David A. Harris;Didier Vilette;Hubert Laude

  • Processing of a cellular prion protein: identification of N- and C-terminal cleavage sites.

    David A. Harris;Mary T. Huber;Peter Van Dijken;Peter Van Dijken;Show Ling Shyng

  • Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

    Bettina Drisaldi;Richard S. Stewart;Cheryl Adles;Leanne R. Stewart

  • Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans

    Andrew P. Jackson;John A. Gamble;Tim Yeomans;Gary P. Moran

  • Brain copper content and cuproenzyme activity do not vary with prion protein expression level.

    Darrel J. Waggoner;Bettina Drisaldi;Thomas B. Bartnikas;Ruby Leah B. Casareno

  • Tightly bound nucleotides of the energy-transducing ATPase of chloroplasts and their role in photophosphorylation.

    David A. Harris;E.C. Slater

  • Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105–125

    Aimin Li;Heather M Christensen;Leanne R Stewart;Kevin A Roth

  • The N-terminal domain of a glycolipid-anchored prion protein is essential for its endocytosis via clathrin-coated pits.

    Show-Ling Shyng;Krista L. Moulder;Alex Lesko;David A. Harris

  • Massive gene decay in the leprosy

    T. Cole;K. Eiglmeier;J. Parkhill;K. D. James

Frequent Co-Authors

Pedro Piccardo
Pedro Piccardo University of Edinburgh
Sylvain Lehmann
Sylvain Lehmann University of Montpellier
Bernardino Ghetti
Bernardino Ghetti Indiana University
Irving L. Kron
Irving L. Kron University of Virginia
James H. Schwartz
James H. Schwartz Columbia University
Glenn L. Millhauser
Glenn L. Millhauser University of California, Santa Cruz
Gerald D. Fischbach
Gerald D. Fischbach Columbia University
Jörg Tatzelt
Jörg Tatzelt Ruhr University Bochum
Gianluigi Forloni
Gianluigi Forloni Mario Negri Institute for Pharmacological Research
Kevin A. Roth
Kevin A. Roth University of Alabama at Birmingham

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