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Biology and Biochemistry

D-Index
48
Citations
8175
World Ranking
18412
National Ranking
1262

Overview

Jörg Tatzelt is affiliated with Ruhr University Bochum in Germany and specializes in research within Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology. Their work extends into related subfields such as Neurology, Nutrition and Dietetics, Physiology, and Epidemiology.

Their research topics cover a range of subjects, including:

  • Prion Diseases and Protein Misfolding
  • Neurological diseases and metabolism
  • RNA Research and Splicing
  • Ubiquitin and proteasome pathways
  • RNA regulation and disease
  • Trace Elements in Health
  • RNA and protein synthesis mechanisms

Jörg Tatzelt has contributed to several scientific publications. Notable recent papers include:

  • "The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS" (2021), published in Biophysical Journal
  • "The N-terminal domain of the prion protein is required and sufficient for liquid-liquid phase separation: A crucial role of the Aβ-binding domain" (2021), published in Journal of Biological Chemistry
  • "Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities" (2022), published in Scientific Reports
  • "Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling" (2023), published in Life Science Alliance
  • "LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus" (2022), published in The EMBO Journal

Their frequent co-authors include:

  • Konstanze F. Winklhofer
  • Verian Bader
  • Janine Kamps
  • Roland Winter
  • Markus Glatzel

Jörg Tatzelt's work has been published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemistry - A European Journal
  • Biophysical Journal
  • Scientific Reports
  • Nature Communications

Best Publications

  • The two faces of protein misfolding: gain‐ and loss‐of‐function in neurodegenerative diseases

    Konstanze F Winklhofer;Jörg Tatzelt;Christian Haass

  • Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

    A. Kathrin Lutz;Nicole Exner;Mareike E. Fett;Julia S. Schlehe

  • Chemical chaperones interfere with the formation of scrapie prion protein.

    J Tatzelt;S B Prusiner;W J Welch

  • Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

    Andreas C. Woerner;Frédéric Frottin;Daniel Hornburg;Li R. Feng

  • Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

    L Bouman;A Schlierf;A K Lutz;J Shan

  • A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

    Hermann M. Schätzl;Lajos Laszlo;David M. Holtzman;David M. Holtzman;Jörg Tatzelt;Jörg Tatzelt

  • The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

    Ulrike K Resenberger;Anja Harmeier;Andreas C Woerner;Jessica L Goodman

  • Parkin Mediates Neuroprotection through Activation of IκB Kinase/Nuclear Factor-κB Signaling

    Iris H. Henn;Lena Bouman;Julia S. Schlehe;Anita Schlierf

  • The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

    Anne Kathrin Müller-Rischart;Anna Pilsl;Patrick Beaudette;Maria Patra

  • Intracellular re‐routing of prion protein prevents propagation of PrPSc and delays onset of prion disease

    Sabine Gilch;Konstanze F. Winklhofer;Martin H. Groschup;Max Nunziante

  • Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

    Sven Lang;Julia Benedix;Sorin V. Fedeles;Stefan Schorr

  • Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones.

    Konstanze F. Winklhofer;Iris H. Henn;Penelope C. Kay-Jackson;Ulrich Heller

  • Pathogenic mutations inactivate parkin by distinct mechanisms

    Iris H Henn;Johanna M Gostner;Peter Lackner;Jörg Tatzelt

  • Stress‐protective signalling of prion protein is corrupted by scrapie prions

    Angelika S Rambold;Veronika Müller;Uri Ron;Nir Ben-Tal

  • Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

    Angelika S. Rambold;Margit Miesbauer;Doron Rapaport;Till Bartke

  • Genes contributing to prion pathogenesis.

    Gültekin Tamgüney;Kurt Giles;David V. Glidden;Pierre Lessard

  • Scrapie prions selectively modify the stress response in neuroblastoma cells.

    Jorg Tatzelt;Jianru Zuo;Richard Voellmy;Michael Scott

  • Propagation of prion strains through specific conformers of the prion protein.

    M R Scott;D Groth;J Tatzelt;M Torchia

  • Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift)

    Uwe Bertsch;Armin Giese;Hans Kretzschmar;Paul Tavan

  • The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS.

    Jonas Ahlers;Ellen M. Adams;Verian Bader;Simone Pezzotti

Frequent Co-Authors

Konstanze F. Winklhofer
Konstanze F. Winklhofer Ruhr University Bochum
Hermann M. Schätzl
Hermann M. Schätzl University of Calgary
Stanley B. Prusiner
Stanley B. Prusiner University of California, San Francisco
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Martin Engelhard
Martin Engelhard Max Planck Society
F. Ulrich Hartl
F. Ulrich Hartl Max Planck Society
Markus Glatzel
Markus Glatzel Universität Hamburg
Armin Giese
Armin Giese Ludwig-Maximilians-Universität München
Richard Zimmermann
Richard Zimmermann Saarland University
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases

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