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Konstanze F. Winklhofer

Konstanze F. Winklhofer

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
21836
World Ranking
14149
National Ranking
997

Overview

Konstanze F. Winklhofer is affiliated with Ruhr University Bochum in Germany. Their research is primarily situated at the intersection of biochemistry, genetics, and molecular biology, with a significant focus also on medicine. The scientist's work spans a diverse range of topics within these fields.

The main fields of study that Winklhofer has contributed to include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their work covers several subfields, notably:

  • Molecular Biology
  • Immunology
  • Neurology
  • Cell Biology
  • Epidemiology

The key topics addressed in their research comprise:

  • Ubiquitin and proteasome pathways
  • Prion diseases and protein misfolding
  • RNA research and splicing
  • Autophagy in disease and therapy
  • Mitochondrial function and pathology
  • Interferon and immune responses
  • Amyotrophic lateral sclerosis research

Konstanze F. Winklhofer has authored numerous scientific publications. Some of the notable recent papers include:

  • "Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism" (2020, Cell)
  • "The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS" (2021, Biophysical Journal)
  • "Linear Ubiquitin Chains: Cellular Functions and Strategies for Detection and Quantification" (2020, Frontiers in Chemistry)
  • "PINK1 and Parkin: team players in stress-induced mitophagy" (2020, Biological Chemistry)
  • "Hypochlorous acid-modified human serum albumin suppresses MHC class II - dependent antigen presentation in pro-inflammatory macrophages" (2021, Redox Biology)

The scientist has frequently published in venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Journal of Biological Chemistry

Winklhofer collaborates regularly with several co-authors, among whom are:

  • Verian Bader
  • Jörg Tatzelt
  • Janine Kamps
  • Ralf Gold
  • María Georgina Herrera

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

    Nicole Exner;Anne Kathrin Lutz;Christian Haass;Konstanze F Winklhofer

  • Mitochondrial dysfunction in Parkinson's disease

    Konstanze F. Winklhofer;Christian Haass

  • Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

    Nicole Exner;Bettina Treske;Dominik Paquet;Kira Holmström

  • Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism

    Alexander Duscha;Barbara Gisevius;Sarah Hirschberg;Nissan Yissachar

  • Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

    Frits Kamp;Frits Kamp;Nicole Exner;Nicole Exner;Anne Kathrin Lutz;Nora Wender

  • The two faces of protein misfolding: gain‐ and loss‐of‐function in neurodegenerative diseases

    Konstanze F Winklhofer;Jörg Tatzelt;Christian Haass

  • Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

    A. Kathrin Lutz;Nicole Exner;Mareike E. Fett;Julia S. Schlehe

  • Loss of the Parkinson’s Disease-linked gene DJ-1 perturbs mitochondrial dynamics

    I. Irrcher;H. Aleyasin;E.L. Seifert;S.J. Hewitt

  • Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

    Andreas C. Woerner;Frédéric Frottin;Daniel Hornburg;Li R. Feng

  • Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress.

    L Bouman;A Schlierf;A K Lutz;J Shan

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

    Ulrike K Resenberger;Anja Harmeier;Andreas C Woerner;Jessica L Goodman

  • Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

    Elisa Motori;Julien Puyal;Nicolas Toni;Alexander Ghanem

  • Parkin Mediates Neuroprotection through Activation of IκB Kinase/Nuclear Factor-κB Signaling

    Iris H. Henn;Lena Bouman;Julia S. Schlehe;Anita Schlierf

  • The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

    Anne Kathrin Müller-Rischart;Anna Pilsl;Patrick Beaudette;Maria Patra

  • Intracellular re‐routing of prion protein prevents propagation of PrPSc and delays onset of prion disease

    Sabine Gilch;Konstanze F. Winklhofer;Martin H. Groschup;Max Nunziante

  • Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones.

    Konstanze F. Winklhofer;Iris H. Henn;Penelope C. Kay-Jackson;Ulrich Heller

  • Parkin and mitochondrial quality control: toward assembling the puzzle

    Konstanze F. Winklhofer

Frequent Co-Authors

Jörg Tatzelt
Jörg Tatzelt Ruhr University Bochum
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
F. Ulrich Hartl
F. Ulrich Hartl Max Planck Society
Martin Engelhard
Martin Engelhard Max Planck Society
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Günter U. Höglinger
Günter U. Höglinger Ludwig Maximilian University of Munich
Evelina Gatti
Evelina Gatti Aix-Marseille University
Armin Giese
Armin Giese Ludwig-Maximilians-Universität München
Hans A. Kretzschmar
Hans A. Kretzschmar Ludwig-Maximilians-Universität München
Shazib Pervaiz
Shazib Pervaiz National University of Singapore

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