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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Molecular Biology

D-Index
118
Citations
53069
World Ranking
280
National Ranking
25

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award

Overview

Wolfgang Wurst is affiliated with the German Center for Neurodegenerative Diseases in Germany. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions also in Medicine. The main subfields in which they publish include Molecular Biology, Neurology, Genetics, Physiology, and Cellular and Molecular Neuroscience.

Their work covers various topics, notably:

  • CRISPR and Genetic Engineering
  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's Disease Research and Treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Adipose Tissue and Metabolism
  • Muscle Physiology and Disorders
  • Genetic and Kidney Cyst Diseases

Frequent co-authors in Wurst's collaborations include Martin Hrabé de Angelis, Helmut Fuchs, Lillian Garrett, Florian Giesert, and Valérie Gailus-Durner.

The scientist has published in a range of journals, with recurring venues being bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Neuroscience Applied, Immunity, and Scientific Reports.

Selected recent publications include:

  • "Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy" (2020, Nature Medicine)
  • "The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs" (2020, Genes & Development)
  • "Human and mouse essentiality screens as a resource for disease gene discovery" (2020, Nature Communications)
  • "A resource of targeted mutant mouse lines for 5,061 genes" (2021, Nature Genetics)
  • "Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics" (2020, Nature Structural & Molecular Biology)

Best Publications

  • ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

    Sebastian Doll;Bettina Proneth;Yulia Y Tyurina;Elena Panzilius

  • Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

    Van Trung Chu;Timm Weber;Benedikt Wefers;Wolfgang Wurst

  • Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

    Alexander Seiler;Manuela Schneider;Heidi Förster;Stephan Roth

  • Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

    Irina Ingold;Carsten Berndt;Sabine Schmitt;Sebastian Doll

  • Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1

    Peter Timpl;Rainer Spanagel;Inge Sillaber;Adelheid Kresse

  • Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

    Niels Plath;Ora Ohana;Ora Ohana;Björn Dammermann;Mick L. Errington

  • Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

    Rüdiger Klein;Richard J. Smeyne;Wolfgang Wurst;Linda K. Long

  • The knockout mouse project

    Christopher P. Austin;James F. Battey;Allan Bradley;Maja Bucan

  • A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

    Wolfgang Enard;Sabine Gehre;Kurt Hammerschmidt;Sabine M. Hölter

  • Neural plate patterning: Upstream and downstream of the isthmic organizer

    Wolfgang Wurst;Laure Bally-Cuif

  • Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.

    Marcus Conrad;Cemile Jakupoglu;Stéphanie G. Moreno;Stefanie Lippl

  • A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

    Michelle M Simon;Simon Greenaway;Jacqueline K White;Helmut Fuchs

  • The mouse Pax21Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney

    Jack Favor;Rodica Sandulache;Angelika Neuhäuser-Klaus;Walter Pretsch

  • Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

    Marianne B Müller;Stephan Zimmermann;Inge Sillaber;Thomas P Hagemeyer

  • Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

    Chinmay M Trivedi;Yang Luo;Yang Luo;Zhan Yin;Zhan Yin;Maozhen Zhang;Maozhen Zhang

  • Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

    A. Kathrin Lutz;Nicole Exner;Mareike E. Fett;Julia S. Schlehe

  • Inducible gene deletion in astroglia and radial glia- : A valuable tool for functional and lineage analysis

    Tetsuji Mori;Kohichi Tanaka;Annalisa Buffo;Wolfgang Wurst

  • EphA -ephrin -a-mediated β cell communication regulates insulin secretion from pancreatic islets

    Irena Konstantinova;Ganka Nikolova;Mica Ohara-Imaizumi;Paolo Meda

  • Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

    Vanessa Morais;Patrik Verstreken;Anne Roethig;Joel Smet

  • Development of an intein-mediated split–Cas9 system for gene therapy

    Dong-Jiunn Jeffery Truong;Karin Kühner;Ralf Kühn;Stanislas Werfel

Frequent Co-Authors

Jan M. Deussing
Jan M. Deussing Max Planck Society
Florian Holsboer
Florian Holsboer Max Planck Institute of Psychiatry
Valerie Gailus-Durner
Valerie Gailus-Durner Helmholtz Zentrum München
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Helmut Fuchs
Helmut Fuchs Helmholtz Zentrum München
Ralf Kühn
Ralf Kühn Max Delbrück Center for Molecular Medicine
Thomas Klopstock
Thomas Klopstock Ludwig-Maximilians-Universität München
Martin Klingenspor
Martin Klingenspor Technical University of Munich
Eckhard Wolf
Eckhard Wolf Ludwig-Maximilians-Universität München
Johannes Beckers
Johannes Beckers Technical University of Munich

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