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Best Female Scientists

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Biology and Biochemistry

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109
Citations
46506
World Ranking
1002
National Ranking
608

Overview

Alexandra L. Joyner is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research spans multiple domains within biochemistry, genetics, molecular biology, and neuroscience.

The main fields of study for Alexandra L. Joyner include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Subfields within their research contributions feature:

  • Molecular Biology
  • Developmental Neuroscience
  • Pediatrics, Perinatology and Child Health
  • Genetics
  • Cell Biology

Their primary research topics cover a range of important biomedical themes:

  • Neurogenesis and neuroplasticity mechanisms
  • Epigenetics and DNA Methylation
  • Mitochondrial Function and Pathology
  • Neuroscience of respiration and sleep
  • Renal and related cancers
  • Single-cell and spatial transcriptomics
  • Fetal and Pediatric Neurological Disorders

Alexandra L. Joyner has published frequently in a number of venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Development
  • Nature
  • Science Advances
  • Cell

Recent publications by this researcher include:

  • Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid, 2020, The Journal of Experimental Medicine
  • Centrosome anchoring regulates progenitor properties and cortical formation, 2020, Nature
  • CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model, 2020, Oncogene
  • Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator, 2020, Cell Reports
  • Patterned cPCDH expression regulates the fine organization of the neocortex, 2022, Nature

Frequent co-authors working alongside Alexandra L. Joyner are:

  • N. Sumru Bayın
  • Zhimin Lao
  • Daniel N. Stephen
  • Richard P. Koche
  • Salsabiel El Nagar

Best Publications

  • A gene expression atlas of the central nervous system based on bacterial artificial chromosomes

    Shiaoching Gong;Chen Zheng;Martin L. Doughty;Kasia Losos

  • Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons

    François Guillemot;Li Ching Lo;Jane E. Johnson;Anna Auerbach

  • Inactivation of the mouse Huntington's disease gene homolog Hdh.

    Mabel P. Duyao;Anna B. Auerbach;Angela Ryan;Francesca Persichetti

  • In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

    Sohyun Ahn;Alexandra L. Joyner;Alexandra L. Joyner

  • The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

    A.P. McMahon;A.L. Joyner;A. Bradley;J.A. McMahon

  • Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation

    H. L. Park;C. Bai;K. A. Platt;Michael Matise

  • Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death

    Rüdiger Klein;Richard J. Smeyne;Wolfgang Wurst;Linda K. Long

  • Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

    C. Brian Bai;Wojtek Auerbach;Wojtek Auerbach;Joon S. Lee;Joon S. Lee;Daniel Stephen;Daniel Stephen

  • A Mouse Model of Greig Cephalopolysyndactyly Syndrome: The extra-toesJ Mutation Contains an Intragenic Deletion of the Gli3 Gene

    Chi-chung Hui;Alexandra L. Joyner;Alexandra L. Joyner

  • The knockout mouse project

    Christopher P. Austin;James F. Battey;Allan Bradley;Maja Bucan

  • Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.

    Yong Pan;Chunyang Brian Bai;Chunyang Brian Bai;Alexandra L. Joyner;Baolin Wang

  • Essential role of Mash-2 in extraembryonic development.

    François Guillemot;François Guillemot;Andras Nagy;Anna Auerbach;Janet Rossant;Janet Rossant

  • Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.

    R. Mo;A. M. Freer;D. L. Zinyk;M. A. Crackower

  • Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.

    Sohyun Ahn;Alexandra L. Joyner;Alexandra L. Joyner

  • Expression of three mouse homologs of the drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development

    Chi Chung Hui;Diane Slusarski;Kenneth A. Platt;Robert Holmgren

  • Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes.

    Achim Gossler;Alexandra L. Joyner;Alexandra L. Joyner;Janet Rossant;Janet Rossant;William C. Skarnes

  • Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.

    Jacqueline K. White;Wojtek Auerbach;Mabel P. Duyao;Jean-Paul Vonsattel

  • Engrailed, Wnt and Pax genes regulate midbrain-hindbrain development

    Alexandra L. Joyner

  • All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3

    C.Brian Bai;Daniel Stephen;Alexandra L. Joyner;Alexandra L. Joyner

  • Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox.

    AL Joyner;K Herrup;BA Auerbach;CA Davis;CA Davis

Frequent Co-Authors

Roy V. Sillitoe
Roy V. Sillitoe Baylor College of Medicine
Marcy E. MacDonald
Marcy E. MacDonald Harvard University
James F. Gusella
James F. Gusella Harvard University
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Hongkui Zeng
Hongkui Zeng Allen Institute for Brain Science
Kathleen J. Millen
Kathleen J. Millen Seattle Children's Hospital
François Guillemot
François Guillemot The Francis Crick Institute
Janet Rossant
Janet Rossant University of Toronto
Michael D. Taylor
Michael D. Taylor University of Toronto
Lincoln Stein
Lincoln Stein Ontario Institute for Cancer Research

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