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2025
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Biology and Biochemistry
USA
2026

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Best Scientists

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185
Citations
122906
World Ranking
515
National Ranking
334

Biology and Biochemistry

D-Index
190
Citations
126598
World Ranking
47
National Ranking
40

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2020 - Member of the National Academy of Sciences
  • 2007 - Fellow of the Royal Society, United Kingdom
  • 2003 - Fellow of the American Academy of Arts and Sciences
  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Andrew P. McMahon is affiliated with the University of Southern California in the United States. Their research spans biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, pulmonary and respiratory medicine, nephrology, genetics, and pediatrics, perinatology, and child health.

The scientist's main research topics include renal and related cancers, renal cell carcinoma treatment, genetic and kidney cyst diseases, acute kidney injury research, single-cell and spatial transcriptomics, birth, development, and health, as well as chronic kidney disease and diabetes.

Recent notable publications include:

  • Multi-omics integration in the age of million single-cell data, 2021, Nature Reviews Nephrology
  • Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury, 2021, Proceedings of the National Academy of Sciences
  • Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality, 2020, Nature Metabolism
  • A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery, 2022, Cell Stem Cell
  • Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors, 2021, Nature Communications

Frequent co-authors in their work include Jinjin Guo, Kari Koppitch, Nils O. Lindström, Jill A. McMahon, and Riana K. Parvez.

Their research has been published predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), the Journal of the American Society of Nephrology, Nature Communications, Proceedings of the National Academy of Sciences, and Developmental Cell.

Andrew P. McMahon has been recognized with several distinctions including being a Member of the National Academy of Sciences (2020), Fellow of the Royal Society, United Kingdom (2007), Fellow of the American Academy of Arts and Sciences (2003), and Fellow of the American Association for the Advancement of Science (AAAS) (2000).

Best Publications

  • Hedgehog signaling in animal development: paradigms and principles.

    Philip W. Ingham;Andrew P. McMahon

  • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

    Yann Echelard;Douglas J. Epstein;Benoit St-Jacques;Liya Shen

  • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

    Benoit St-Jacques;Matthias Hammerschmidt;Andrew P. McMahon

  • The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

    Andrew P. McMahon;Allan Bradley

  • Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation

    Donald A. Glass;Peter Bialek;Jong Deok Ahn;Michael Starbuck

  • Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo.

    Mark J. Bitgood;Andrew P. McMahon

  • Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis

    Y. Chai;X. Jiang;Y. Ito;P. Bringas

  • Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse.

    Shigemi Hayashi;Andrew P. McMahon

  • Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

    Benjamin D. Humphreys;Benjamin D. Humphreys;Shuei Liong Lin;Shuei Liong Lin;Akio Kobayashi;Thomas E. Hudson

  • Female development in mammals is regulated by Wnt-4 signalling

    Seppo Vainio;Minna Heikkilä;Andreas Kispert;Norman Chin

  • Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

    Paul S. Danielian;David Muccino;David H. Rowitch;Simon K. Michael

  • Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.

    A. M. Clement;M. D. Nguyen;E. A. Roberts;E. A. Roberts;M. L. Garcia;M. L. Garcia

  • Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors

    Stephen J. Rodda;Andrew P. McMahon

  • Fate of the mammalian cardiac neural crest.

    X. Jiang;D.H. Rowitch;P. Soriano;A.P. McMahon

  • Derivation of embryonic stem-cell lines from human blastocysts.

    Chad A. Cowan;Irinha Klimanskaya;Jill Mcmahon;Jocelyn Atienza

  • Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.

    Kevin Stark;Seppo Vainio;Galya Vassileva;Galya Vassileva;Andrew P. McMahon

  • Neural crest origins of the neck and shoulder

    Toshiyuki Matsuoka;Per E. Ahlberg;Nicoletta Kessaris;Palma Iannarelli

  • A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.

    Terry P. Yamaguchi;Allan Bradley;Andrew P. McMahon;Steven Jones

  • Developmental roles and clinical significance of hedgehog signaling.

    Andrew P McMahon;Philip W Ingham;Clifford J Tabin

  • Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein

    Pao-Tien Chuang;Andrew P. McMahon

Frequent Co-Authors

Jill A. McMahon
Jill A. McMahon University of Southern California
David H. Rowitch
David H. Rowitch University of Cambridge
Clifford J. Tabin
Clifford J. Tabin Harvard University
Melissa H. Little
Melissa H. Little Murdoch Children's Research Institute
Benjamin D. Humphreys
Benjamin D. Humphreys Washington University in St. Louis
Shinji Takada
Shinji Takada National Institutes of Natural Sciences
Andreas Kispert
Andreas Kispert Hannover Medical School
Henry M. Kronenberg
Henry M. Kronenberg Harvard University
Alexander van Oudenaarden
Alexander van Oudenaarden University Medical Center Utrecht
Bruce J. Aronow
Bruce J. Aronow Cincinnati Children's Hospital Medical Center

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