World's Best Scientists 2026 revealed!
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Biology and Biochemistry
UK
2023

D-Index & Metrics

Molecular Biology

D-Index
95
Citations
30346
World Ranking
639
National Ranking
53

Medicine

D-Index
96
Citations
31211
World Ranking
9743
National Ranking
946

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Paul T. Sharpe is affiliated with King's College London in the United Kingdom. Their research primarily focuses on dental biology, stem cell research, and molecular mechanisms related to oral health and regenerative processes. Their work spans several interconnected topics within biochemistry, genetics, molecular biology, and medicine.

The scientist's major research areas include:

  • Dental development and anomalies
  • Mesenchymal stem cell research
  • Bone and dental protein studies
  • Single-cell and spatial transcriptomics
  • Periodontal regeneration and treatments
  • Oral microbiology and periodontitis research
  • Extracellular vesicles in disease

Their fields of study are predominantly within:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of focus include:

  • Molecular Biology
  • Genetics
  • Immunology
  • Rheumatology
  • Biomedical Engineering

Paul T. Sharpe's contributions appear in various scientific venues, with frequent publications in:

  • Frontiers in Dental Medicine
  • eLife
  • Journal of Dental Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Selected recent papers include:

  • "Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth", 2020, Nature Communications
  • "Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory disease", 2021, eLife
  • "Translation Approach for Dentine Regeneration Using GSK-3 Antagonists", 2020, Journal of Dental Research
  • "Stem cell contributions to cementoblast differentiation in healthy periodontal ligament and periodontitis", 2020, Stem Cells
  • "Macrophage modulation of dental pulp stem cell activity during tertiary dentinogenesis", 2020, Scientific Reports

Frequent collaborators with whom Paul T. Sharpe has co-authored multiple papers include:

  • Ana Angelova Volponi
  • Anahid A. Birjandi
  • Ana J Caetano
  • Val Yianni
  • Vitor C. M. Neves

Best Publications

  • Signalling networks regulating dental development

    Irma Thesleff;Paul Sharpe

  • The cutting-edge of mammalian development; how the embryo makes teeth

    Abigail Tucker;Paul Sharpe

  • Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.

    Mengsheng Qiu;Alessandro Bulfone;Ingrid Ghattas;Juanito J. Meneses

  • Stem-cell-based Tissue Engineering of Murine Teeth

    Atsushi Ohazama;S A C Modino;Isabelle Miletich;Paul Sharpe

  • Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development.

    Dafe Uwanogho;Maria Rex;Elizabeth J. Cartwright;Gina Pearl

  • Transformation of Tooth Type Induced by Inhibition of BMP Signaling

    Abigail S. Tucker;Karen L. Matthews;Paul T. Sharpe

  • An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

    Aideen O'Doherty;Sandra Ruf;Sandra Ruf;Claire Mulligan;Victoria Hildreth

  • The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants

    Zoë Hardcastle;Rong Mo;Chi-chung Hui;Paul T. Sharpe

  • Dual origin of mesenchymal stem cells contributing to organ growth and repair

    Jifan Feng;Andrea Mantesso;Andrea Mantesso;Cosimo De Bari;Akiko Nishiyama

  • Glial origin of mesenchymal stem cells in a tooth model system

    Nina Kaukua;Maryam Khatibi Shahidi;Chrysoula Konstantinidou;Vyacheslav Dyachuk

  • Gene defect in ectodermal dysplasia implicates a death domain adapter in development.

    Denis J. Headon;Stephanie A. Emmal;Betsy M. Ferguson;Abigail S. Tucker

  • Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape

    Alasdair MacKenzie;Mark Ferguson;Paul T. Sharpe

  • Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

    Hu Zhao;Jifan Feng;Kerstin Seidel;Songtao Shi

  • 19 – Craniofacial Development

    Michael J. Depew;Abigail S. Tucker;Paul T. Sharpe

  • Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development

    Maria Grigoriou;Abigail S. Tucker;Paul T. Sharpe;Vassilis Pachnis

  • Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy.

    Jane E. Hewitt;Jane E. Hewitt;Robert Lyle;Lorraine N. Clark;Elizabeth M. Valleley

  • Stem cell-based biological tooth repair and regeneration

    Ana Angelova Volponi;Yvonne Pang;Yvonne Pang;Paul T. Sharpe

  • The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro

    A. Mackenzie;G. L. Leeming;A. K. Jowett;M. W. J. Ferguson

  • Molecular Genetics of Tooth Morphogenesis and Patterning: The Right Shape in the Right Place

    A.S. Tucker;P.T. Sharpe

  • Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition.

    B.L. Thomas;A.S. Tucker;M. Qui;C.A. Ferguson

Frequent Co-Authors

Abigail S. Tucker
Abigail S. Tucker King's College London
Sebastian M. Shimeld
Sebastian M. Shimeld University of Oxford
Ariane Berdal
Ariane Berdal Université Paris Cité
Mark W. J. Ferguson
Mark W. J. Ferguson University of Manchester
Jill A. Helms
Jill A. Helms Stanford University
Thimios A. Mitsiadis
Thimios A. Mitsiadis University of Zurich
Joachim Herz
Joachim Herz The University of Texas Southwestern Medical Center
Ellen Solomon
Ellen Solomon King's College London
Vassilis Pachnis
Vassilis Pachnis The Francis Crick Institute
John L.R. Rubenstein
John L.R. Rubenstein University of California, San Francisco

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