His main research concerns Cell biology, Anatomy, Mesenchyme, Genetics and Homeobox. His Cell biology study integrates concerns from other disciplines, such as Molar, Epithelium and Morphogenesis. His work carried out in the field of Epithelium brings together such families of science as Internal medicine, Gene expression, Activator and Endocrinology.
His studies deal with areas such as Ectomesenchyme, Neural crest, Stem cell transplantation for articular cartilage repair, Ectoderm and Stem cell as well as Anatomy. The various areas that he examines in his Mesenchyme study include Signal transduction, Mesoderm, Organogenesis, Bone morphogenetic protein and Dental papilla. Paul T. Sharpe combines subjects such as Stromal cell and Immunology with his study of Mesenchymal stem cell.
Paul T. Sharpe spends much of his time researching Cell biology, Anatomy, Mesenchyme, Mesenchymal stem cell and Genetics. His Cell biology research includes elements of Epithelium, Morphogenesis and Cellular differentiation. His study explores the link between Anatomy and topics such as Ectoderm that cross with problems in Endoderm.
The Mesenchyme study combines topics in areas such as Gene expression, Molar, Mesoderm, Organogenesis and Dental papilla. His Gene expression research is multidisciplinary, incorporating elements of Molecular biology and Regulation of gene expression. While the research belongs to areas of Mesenchymal stem cell, Paul T. Sharpe spends his time largely on the problem of Stem cell transplantation for articular cartilage repair, intersecting his research to questions surrounding Clinical uses of mesenchymal stem cells.
Paul T. Sharpe mainly focuses on Cell biology, Mesenchymal stem cell, Stem cell, Wnt signaling pathway and Regeneration. His research integrates issues of Stromal cell, Cellular differentiation, Anatomy and Pulp, Odontoblast in his study of Cell biology. As a part of the same scientific family, Paul T. Sharpe mostly works in the field of Anatomy, focusing on Neural crest and, on occasion, Morphogenesis.
His Mesenchymal stem cell study combines topics from a wide range of disciplines, such as Cell, Tissue homeostasis, Cancer research and Embryonic stem cell, Adult stem cell. His Stem cell research incorporates themes from Transcriptome, Ectopic expression and Dentin, Pathology. Paul T. Sharpe works mostly in the field of Wnt signaling pathway, limiting it down to concerns involving Fibroblast growth factor and, occasionally, Phenotype.
The scientist’s investigation covers issues in Cell biology, Mesenchymal stem cell, Stem cell, Cellular differentiation and Anatomy. Paul T. Sharpe studies Wnt signaling pathway which is a part of Cell biology. His Mesenchymal stem cell study incorporates themes from Cell, In vitro, Secretion and In vivo.
The concepts of his Stem cell study are interwoven with issues in Reparative dentine, Regeneration and Dentin. The study incorporates disciplines such as Embryonic stem cell and Accelerated Growth in addition to Cellular differentiation. His Anatomy study which covers Neural crest that intersects with Neuroscience, Zebrafish, Morphogenesis and Ectoderm.
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Signalling networks regulating dental development
Irma Thesleff;Paul Sharpe.
Mechanisms of Development (1997)
Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.
Mengsheng Qiu;Alessandro Bulfone;Ingrid Ghattas;Juanito J. Meneses.
Developmental Biology (1997)
The cutting-edge of mammalian development; how the embryo makes teeth
Abigail Tucker;Paul Sharpe.
Nature Reviews Genetics (2004)
Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development.
Dafe Uwanogho;Maria Rex;Elizabeth J. Cartwright;Gina Pearl.
Mechanisms of Development (1995)
Stem-cell-based Tissue Engineering of Murine Teeth
Atsushi Ohazama;S A C Modino;Isabelle Miletich;Paul Sharpe.
Journal of Dental Research (2004)
Transformation of Tooth Type Induced by Inhibition of BMP Signaling
Abigail S. Tucker;Karen L. Matthews;Paul T. Sharpe.
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
Zoë Hardcastle;Rong Mo;Chi-chung Hui;Paul T. Sharpe.
An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes
Aideen O'Doherty;Sandra Ruf;Sandra Ruf;Claire Mulligan;Victoria Hildreth.
Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape
Alasdair MacKenzie;Mark Ferguson;Paul T. Sharpe.
Dual origin of mesenchymal stem cells contributing to organ growth and repair
Jifan Feng;Andrea Mantesso;Andrea Mantesso;Cosimo De Bari;Akiko Nishiyama.
Proceedings of the National Academy of Sciences of the United States of America (2011)
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