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Molecular Biology

D-Index
70
Citations
16520
World Ranking
1426
National Ranking
726

Overview

Ophir D. Klein is affiliated with the University of California, San Francisco in the United States. Their research is primarily situated within the broad fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

Their main subfields of study include Molecular Biology, Genetics, Oncology, Cell Biology, and Biomedical Engineering. The researcher's work covers a range of topics such as Cancer Cells and Metastasis, dental development and anomalies, Digestive system and related health, Fibroblast Growth Factor Research, Cellular Mechanics and Interactions, 3D Printing in Biomedical Research, and Genomic variations and chromosomal abnormalities.

Recent representative publications by Ophir D. Klein include:

  • Molecular and cellular mechanisms of tooth development, homeostasis and repair, 2020, Development
  • Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth, 2020, Nature Communications
  • Lgr5+ telocytes are a signaling source at the intestinal villus tip, 2020, Nature Communications
  • Engineering synthetic morphogen systems that can program multicellular patterning, 2020, Science
  • Programming multicellular assembly with synthetic cell adhesion molecules, 2022, Nature

Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Stem Cell, Journal of Dental Research, and Development.

Ophir D. Klein has collaborated repeatedly with several researchers, notably Benedikt Hallgrímsson, Richard A. Spritz, Dario Boffelli, Harold Matthews, and Peter Claes.

Best Publications

  • A reserve stem cell population in small intestine renders Lgr5 -positive cells dispensable

    Hua Tian;Brian Biehs;Søren Warming;Kevin G. Leong

  • The branching programme of mouse lung development

    Ross J. Metzger;Ophir D. Klein;Gail R. Martin;Mark A. Krasnow

  • In vitro generation of human pluripotent stem cell derived lung organoids

    Briana R Dye;David R Hill;Michael A H Ferguson;Yu-Hwai Tsai

  • The genome architecture of the collaborative cross mouse genetic reference population

    Fuad A. Iraqi;Mustafa Mahajne;Yasser Salaymah;Hani Sandovski

  • Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor

    Hu Zhao;Jifan Feng;Kerstin Seidel;Songtao Shi

  • Sprouty Genes Control Diastema Tooth Development via Bidirectional Antagonism of Epithelial-Mesenchymal FGF Signaling

    Ophir D. Klein;George Minowada;George Minowada;Renata Peterkova;Aapo Kangas

  • Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche

    Ysbrand M. Nusse;Adam K. Savage;Pauline Marangoni;Axel K. M. Rosendahl-Huber

  • Sox2+ Stem Cells Contribute to All Epithelial Lineages of the Tooth via Sfrp5+ Progenitors

    Emma Juuri;Kan Saito;Laura Ahtiainen;Kerstin Seidel

  • Inhibition of Wnt signaling by Wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning

    Youngwook Ahn;Brian W. Sanderson;Ophir D. Klein;Robb Krumlauf;Robb Krumlauf

  • Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo

    Stacy R. Finkbeiner;David R. Hill;Christopher H. Altheim;Priya H. Dedhia

  • Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis

    Vicki Plaks;Audrey Brenot;Devon A. Lawson;Jelena R. Linnemann

  • An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice.

    Jimmy Kuang-Hsien Hu;Wei Du;Wei Du;Samuel J. Shelton;Michael C. Oldham

  • Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis

    Hua Tian;Brian Biehs;Cecilia Chiu;Christian W. Siebel

  • Assessment of endometrial volume by three-dimensional ultrasound prior to embryo transfer: clues to endometrial receptivity

    F. Raga;F. Bonilla-Musoles;E.M. Casañ;O. Klein;O. Klein

  • Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor

    Kerstin Seidel;Christina P. Ahn;David Lyons;Alexander Nee

  • An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors

    Ophir D. Klein;David B. Lyons;Guive Balooch;Grayson W. Marshall

  • Molecular and cellular mechanisms of tooth development, homeostasis and repair.

    Tingsheng Yu;Ophir D. Klein

  • Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology

    John R. Shaffer;Ekaterina Orlova;Myoung Keun Lee;Elizabeth J. Leslie

  • Sox2 marks epithelial competence to generate teeth in mammals and reptiles.

    Emma Juuri;Maria Jussila;Kerstin Seidel;Scott Holmes

  • Dramatic Increase in Incidence of Ulcerative Colitis and Crohn’s Disease (1988–2011): A Population-Based Study of French Adolescents

    Ghione S;Sarter H;Fumery M;Armengol-Debeir L

Frequent Co-Authors

Benedikt Hallgrímsson
Benedikt Hallgrímsson Alberta Children's Hospital
Richard A. Spritz
Richard A. Spritz University of Colorado Denver
Robb Krumlauf
Robb Krumlauf Stowers Institute for Medical Research
Katherine A. Rauen
Katherine A. Rauen University of California, Davis
Axel Visel
Axel Visel Lawrence Berkeley National Laboratory
Gail R. Martin
Gail R. Martin University of California, San Francisco
Laurence S. Baskin
Laurence S. Baskin University of California, San Francisco
Yang Chai
Yang Chai Hong Kong Polytechnic University
Richard L. Maas
Richard L. Maas Brigham and Women's Hospital

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