What is he best known for?
The fields of study he is best known for:
Frederic J. de Sauvage mainly focuses on Cell biology, Cancer research, Hedgehog signaling pathway, Immunology and Smoothened Receptor.
His research integrates issues of Endothelial stem cell, IL-2 receptor and Cellular differentiation in his study of Cell biology.
In general Cancer research study, his work on Stromal cell often relates to the realm of DDX3X, thereby connecting several areas of interest.
His research in Hedgehog signaling pathway intersects with topics in Endocrinology, Hedgehog and Internal medicine.
His Hedgehog research incorporates elements of Carcinogenesis and Paracrine signalling.
His Smoothened Receptor research integrates issues from Mutation, Patched and PTCH1.
His most cited work include:
- Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17 (1611 citations)
- Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens (1410 citations)
- Influence of tumour micro-environment heterogeneity on therapeutic response (1300 citations)
What are the main themes of his work throughout his whole career to date?
Frederic J. de Sauvage mainly investigates Cell biology, Cancer research, Hedgehog signaling pathway, Smoothened and Hedgehog.
His Cell biology research includes elements of Receptor, Cellular differentiation and Molecular biology.
His Cancer research research is multidisciplinary, incorporating elements of Carcinogenesis, Cancer, Paracrine signalling, Immunology and Basal cell carcinoma.
His work in Hedgehog signaling pathway tackles topics such as Internal medicine which are related to areas like Oncology.
His studies in Smoothened integrate themes in fields like Sonic hedgehog, Vismodegib, Patched and Mutation.
As a part of the same scientific family, Frederic J. de Sauvage mostly works in the field of Hedgehog, focusing on Neural stem cell and, on occasion, Chondrogenesis and Cell.
He most often published in these fields:
- Cell biology (33.03%)
- Cancer research (27.60%)
- Hedgehog signaling pathway (22.17%)
What were the highlights of his more recent work (between 2013-2021)?
- Cancer research (27.60%)
- Cell biology (33.03%)
- Stem cell (13.57%)
In recent papers he was focusing on the following fields of study:
The scientist’s investigation covers issues in Cancer research, Cell biology, Stem cell, LGR5 and Smoothened.
His Cancer research study combines topics in areas such as Cancer, Colorectal cancer, Genetics, Basal cell carcinoma and Exome.
His work in Cell biology is not limited to one particular discipline; it also encompasses Protein family.
His study in Stem cell is interdisciplinary in nature, drawing from both Wnt signaling pathway, Cellular differentiation, Immunology, Intestinal epithelium and Receptor.
The various areas that Frederic J. de Sauvage examines in his LGR5 study include Endothelial stem cell, Adult stem cell, Crypt and Cell.
Hedgehog signaling pathway and Hedgehog are the main areas of his Smoothened studies.
Between 2013 and 2021, his most popular works were:
- Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations (392 citations)
- A comprehensive transcriptional portrait of human cancer cell lines (381 citations)
- A distinct role for Lgr5 + stem cells in primary and metastatic colon cancer (326 citations)
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