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Frederic J. de Sauvage

Frederic J. de Sauvage

Genentech
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
108
Citations
57680
World Ranking
1032
National Ranking
624

Frederic J. de Sauvage publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Frederic J. de Sauvage sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 219 publications — 57th percentile

57% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Frederic J. de Sauvage D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Frederic J. de Sauvage sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 108 D-Index — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Frederic J. de Sauvage is affiliated with Genentech in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology.

Their research spans key subfields such as Molecular Biology, Immunology, Oncology, Genetics, and Surgery. The main topics addressed in their work include:

  • Cancer Cells and Metastasis
  • Immune Cell Function and Interaction
  • Peptidase Inhibition and Analysis
  • PI3K/AKT/mTOR signaling in cancer
  • IL-33, ST2, and ILC Pathways
  • Cancer Genomics and Diagnostics
  • Pancreatic and Hepatic Oncology Research

Frederic J. de Sauvage has published research in several notable journals, frequently appearing in:

  • Cell Stem Cell (2 publications)
  • Nature (2 publications)
  • Nature Communications (2 publications)
  • Molecular Cancer Research (2 publications)
  • Nature Immunology (1 publication)

Among recent papers, key publications include:

  • "Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient," 2020, Cell Stem Cell
  • "Antibody targeting of E3 ubiquitin ligases for receptor degradation," 2022, Nature
  • "Lgr5+ telocytes are a signaling source at the intestinal villus tip," 2020, Nature Communications
  • "Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues," 2021, Nature Immunology
  • "Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation," 2022, Nature

Frequent collaborators include Elaine E. Storm, Noelyn M. Kljavin, Felipe de Sousa e Melo, Varun N. Kapoor, and Shannon J. Turley. These coauthors have worked alongside Frederic J. de Sauvage in multiple publications, with the highest collaboration count being seven publications with Elaine E. Storm.

Best Publications

  • Influence of tumour micro-environment heterogeneity on therapeutic response

    Melissa R. Junttila;Frederic J. de Sauvage

  • Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

    Sudeepta Aggarwal;Nico Ghilardi;Ming-Hong Xie;Frederic J. de Sauvage

  • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

    Yan Zheng;Patricia A Valdez;Dimitry M Danilenko;Yan Hu

  • Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

    Frederic J. de Sauvage;Philip E. Hass;Susan D. Spencer;Beth E. Malloy

  • Activating Smoothened mutations in sporadic basal-cell carcinoma.

    Jingwu Xie;Jingwu Xie;Maximilien Murone;Shiuh Ming Luoh;Anne Ryan

  • The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

    Donna M. Stone;Mary Hynes;Mark Armanini;Todd A. Swanson

  • Characterization of a multicomponent receptor for GDNF

    James J. S. Treanor;Laurie Goodman;Frederic de Sauvage;Donna M. Stone

  • Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

    Daniel D. Von Hoff;Patricia M. LoRusso;Charles M. Rudin;Josina C. Reddy

  • A reserve stem cell population in small intestine renders Lgr5 -positive cells dispensable

    Hua Tian;Brian Biehs;Søren Warming;Kevin G. Leong

  • Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

    Charles M. Rudin;Christine L. Hann;John Laterra;Robert L. Yauch

  • A paracrine requirement for hedgehog signalling in cancer

    Robert L. Yauch;Stephen E. Gould;Suzie J. Scales;Tracy Tang

  • Diverse somatic mutation patterns and pathway alterations in human cancers

    Zhengyan Kan;Bijay S. Jaiswal;Jeremy Stinson;Vasantharajan Janakiraman

  • Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

    Charles M Rudin;Steffen Durinck;Eric W Stawiski;John T Poirier

  • Recurrent R-spondin fusions in colon cancer

    Somasekar Seshagiri;Eric W. Stawiski;Steffen Durinck;Zora Modrusan

  • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

    Marcel Batten;J i Li;Sothy Yi;Noelyn M Kljavin

  • Targeting the Hedgehog pathway in cancer

    Lee L. Rubin;Frederic J. de Sauvage

  • Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma

    Robert L. Yauch;Gerrit J. P. Dijkgraaf;Bruno Alicke;Thomas Januario

  • Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

    Raphael Bueno;Eric W Stawiski;Leonard D Goldstein;Steffen Durinck

  • Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

    Suzie J. Scales;Frederic J. de Sauvage

  • Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

    Sharon L. Erickson;Frederic J. de Sauvage;Kristine Kikly;Karen Carver-Moore

Frequent Co-Authors

Zora Modrusan
Zora Modrusan Genentech
Nico Ghilardi
Nico Ghilardi Genentech
Somasekar Seshagiri
Somasekar Seshagiri Genentech
Dan L. Eaton
Dan L. Eaton Genentech
Audrey Goddard
Audrey Goddard Gilead Sciences
Zemin Zhang
Zemin Zhang Peking University
Ophir D. Klein
Ophir D. Klein University of California, San Francisco
Florian Gnad
Florian Gnad Roche (Germany)
Lee L. Rubin
Lee L. Rubin Harvard University
Heidi S. Phillips
Heidi S. Phillips Genentech

External Links

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Best Scientists Citing Frederic J. de Sauvage

Hans Clevers

Hans Clevers

Hubrecht Institute for Developmental Biology and Stem Cell Research

Publications: 94

Michael D. Taylor

Michael D. Taylor

University of Toronto

Publications: 69

Jay K. Kolls

Jay K. Kolls

Tulane University

Publications: 65

Matthew Meyerson

Matthew Meyerson

Harvard University

Publications: 62

Charles M. Rudin

Charles M. Rudin

Memorial Sloan Kettering Cancer Center

Publications: 61

Andrew P. McMahon

Andrew P. McMahon

University of Southern California

Publications: 57

Takashi Kato

Takashi Kato

Waseda University

Publications: 56

Eric S. Lander

Eric S. Lander

Broad Institute

Publications: 54

Vijay K. Kuchroo

Vijay K. Kuchroo

Harvard University

Publications: 54

Ophir D. Klein

Ophir D. Klein

University of California, San Francisco

Publications: 53

Stefan M. Pfister

Stefan M. Pfister

German Cancer Research Center

Publications: 53

Gad Getz

Gad Getz

Broad Institute

Publications: 52

Christopher A. Hunter

Christopher A. Hunter

University of Pennsylvania

Publications: 50

Wenjun Ouyang

Wenjun Ouyang

Amgen (United States)

Publications: 50

Philip A. Beachy

Philip A. Beachy

Stanford University

Publications: 49

Matthew P. Scott

Matthew P. Scott

Stanford University

Publications: 46

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