Frederic J. de Sauvage

Overview

Best Publications

• Influence of tumour micro-environment heterogeneity on therapeutic response

  Melissa R. Junttila;Frederic J. de Sauvage

  2656
  Citations

• Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

  Sudeepta Aggarwal;Nico Ghilardi;Ming-Hong Xie;Frederic J. de Sauvage

  2528
  Citations

• Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

  Yan Zheng;Patricia A Valdez;Dimitry M Danilenko;Yan Hu

  2293
  Citations

• Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

  Frederic J. de Sauvage;Philip E. Hass;Susan D. Spencer;Beth E. Malloy

  1728
  Citations

• Activating Smoothened mutations in sporadic basal-cell carcinoma.

  Jingwu Xie;Jingwu Xie;Maximilien Murone;Shiuh Ming Luoh;Anne Ryan

  1606
  Citations

• The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

  Donna M. Stone;Mary Hynes;Mark Armanini;Todd A. Swanson

  1431
  Citations

• Characterization of a multicomponent receptor for GDNF

  James J. S. Treanor;Laurie Goodman;Frederic de Sauvage;Donna M. Stone

  1344
  Citations

• Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

  Daniel D. Von Hoff;Patricia M. LoRusso;Charles M. Rudin;Josina C. Reddy

  1331
  Citations

• A reserve stem cell population in small intestine renders Lgr5 -positive cells dispensable

  Hua Tian;Brian Biehs;Søren Warming;Kevin G. Leong

  1296
  Citations

• Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

  Charles M. Rudin;Christine L. Hann;John Laterra;Robert L. Yauch

  1198
  Citations

• A paracrine requirement for hedgehog signalling in cancer

  Robert L. Yauch;Stephen E. Gould;Suzie J. Scales;Tracy Tang

  1184
  Citations

• Diverse somatic mutation patterns and pathway alterations in human cancers

  Zhengyan Kan;Bijay S. Jaiswal;Jeremy Stinson;Vasantharajan Janakiraman

  1175
  Citations

• Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

  Charles M Rudin;Steffen Durinck;Eric W Stawiski;John T Poirier

  1097
  Citations

• Recurrent R-spondin fusions in colon cancer

  Somasekar Seshagiri;Eric W. Stawiski;Steffen Durinck;Zora Modrusan

  1090
  Citations

• Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

  Marcel Batten;J i Li;Sothy Yi;Noelyn M Kljavin

  1073
  Citations

• Targeting the Hedgehog pathway in cancer

  Lee L. Rubin;Frederic J. de Sauvage

  1014
  Citations

• Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma

  Robert L. Yauch;Gerrit J. P. Dijkgraaf;Bruno Alicke;Thomas Januario

  991
  Citations

• Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

  Raphael Bueno;Eric W Stawiski;Leonard D Goldstein;Steffen Durinck

  834
  Citations

• Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

  Suzie J. Scales;Frederic J. de Sauvage

  787
  Citations

• Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

  Sharon L. Erickson;Frederic J. de Sauvage;Kristine Kikly;Karen Carver-Moore

  720
  Citations