World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
104
Citations
61070
World Ranking
1228
National Ranking
727

Research.com Recognitions

  • 2011 - Keio Medical Science Prize, Keio University, Tokyo, Japan
  • 2003 - Fellow of the American Academy of Arts and Sciences
  • 2002 - Member of the National Academy of Sciences
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1987 - Fellow of Alfred P. Sloan Foundation

Overview

Philip A. Beachy is affiliated with Stanford University in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions to medicine. The main subfields of study include molecular biology, oncology, genetics, cancer research, and surgery.

Their work frequently explores themes related to single-cell and spatial transcriptomics, Hedgehog signaling pathway studies, cancer-related molecular mechanisms, epigenetics and DNA methylation, cell image analysis techniques, cancer cells and metastasis, and immune cells in cancer.

Beachy has published extensively in notable scientific venues including Nature, bioRxiv (Cold Spring Harbor Laboratory), Clinical Cancer Research, Nature Reviews Molecular Cell Biology, and Nature Computational Science. These publications reflect their engagement with cutting-edge research across molecular and cellular biology.

Recent papers authored or co-authored by Beachy include:

  • A single-cell transcriptomic atlas characterizes ageing tissues in the mouse (2020), published in Nature
  • Ageing hallmarks exhibit organ-specific temporal signatures (2020), published in Nature
  • Cellular and molecular mechanisms of Hedgehog signalling (2023), published in Nature Reviews Molecular Cell Biology
  • Molecular hallmarks of heterochronic parabiosis at single-cell resolution (2022), published in Nature
  • Adversarial domain translation networks for integrating large-scale atlas-level single-cell datasets (2022), published in Nature Computational Science

Beachy collaborates frequently with a number of colleagues, including Michael F. Clarke, Aaron M. Kershner, Wan-Jin Lu, Jane Antony, and Isaac Bakerman. These partnerships underscore a collaborative approach to investigations at the frontier of molecular biology and oncology.

The scientist's recognition in the academic community includes distinctions such as the Keio Medical Science Prize from Keio University, Tokyo, awarded in 2011. Additional honors include election as a Fellow of the American Academy of Arts and Sciences in 2003, membership in the National Academy of Sciences since 2002, fellowship in the American Association for the Advancement of Science from 2001, and fellowship from the Alfred P. Sloan Foundation dating back to 1987.

Best Publications

  • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.

    Chin Chiang;Ying Litingtung;Eric Lee;Keith E. Young

  • The Hedgehog and Wnt signalling pathways in cancer

    Jussi Taipale;Philip A. Beachy

  • Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.

    James K. Chen;Jussi Taipale;Michael K. Cooper;Philip A. Beachy

  • Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

    Jeffery A. Porter;Keith E. Young;Philip A. Beachy

  • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

    David M. Berman;Sunil S. Karhadkar;Anirban Maitra;Rocio Montes De Oca

  • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

    Jussi Taipale;James K. Chen;Michael K. Cooper;Baolin Wang

  • Tissue repair and stem cell renewal in carcinogenesis

    Philip A. Beachy;Philip A. Beachy;Sunil S. Karhadkar;Sunil S. Karhadkar;David M. Berman

  • Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

    D. Neil Watkins;David M. Berman;Scott G. Burkholder;Baolin Wang

  • Hedgehog signaling in prostate regeneration neoplasia and metastasis

    Philip A. Beachy;David M. Berman;Sunil S. Karhadkar

  • A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

    Nicole Almanzar;Jane Antony;Ankit S. Baghel

  • Hedgehog-Regulated Processing of Gli3 Produces an Anterior/Posterior Repressor Gradient in the Developing Vertebrate Limb

    Baolin Wang;John F Fallon;Philip A Beachy

  • Small molecule modulation of Smoothened activity.

    James K. Chen;Jussi Taipale;Keith E. Young;Tapan Maiti

  • Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

    H Roelink;J.A Porter;C Chiang;Y Tanabe

  • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

    Chen Zhao;Alan Chen;Catriona H. Jamieson;Mark Fereshteh

  • Teratogen-mediated inhibition of target tissue response to Shh signaling.

    Michael K. Cooper;Jeffery A. Porter;Keith E. Young;Philip A. Beachy

  • Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

    David M. Berman;Sunil S. Karhadkar;Andrew R. Hallahan;Joel I. Pritchard

  • The Hedgehog response network: sensors, switches, and routers.

    Lawrence Lum;Philip A. Beachy

  • Patched acts catalytically to suppress the activity of Smoothened

    J. Taipale;M. K. Cooper;T. Maiti;P. A. Beachy

  • Molecular Genetics of the Bithorax Complex in Drosophila melanogaster

    Welcome Bender;Michael Akam;François Karch;Philip A. Beachy

  • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

    John J. Lee;Doris P. von Kessler;Suki Parks;Philip A. Beachy

Frequent Co-Authors

James K. Chen
James K. Chen Stanford University
Jussi Taipale
Jussi Taipale University of Cambridge
David M. Berman
David M. Berman Queen's University
Daniel J. Leahy
Daniel J. Leahy Johns Hopkins University School of Medicine
Stephen C. Ekker
Stephen C. Ekker Mayo Clinic
Lawrence G. Lum
Lawrence G. Lum University of Virginia
Yifan Cheng
Yifan Cheng University of California, San Francisco
Michael F. Clarke
Michael F. Clarke Stanford University
Marlene Rabinovitch
Marlene Rabinovitch Stanford University
David S. Hogness
David S. Hogness Stanford University

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