D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 66 Citations 17,451 266 World Ranking 5499 National Ranking 2642

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Internal medicine

Lawrence G. Lum mainly investigates Cell biology, Signal transduction, Bone marrow, Wnt signaling pathway and Cellular differentiation. His biological study spans a wide range of topics, including Molecular biology and Metalloproteinase. His Signal transduction research focuses on Tissue homeostasis and how it connects with Anatomy.

Bone marrow is a subfield of Immunology that Lawrence G. Lum investigates. His Immunology research includes themes of Autoimmune neutropenia and Neutropenia. His study explores the link between Surgery and topics such as Gastroenterology that cross with problems in Internal medicine, Methotrexate, Prospective cohort study, Cumulative incidence and Pharmacotherapy.

His most cited work include:

  • Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia (1233 citations)
  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer (1107 citations)
  • The Hedgehog Response Network: Sensors, Switches, and Routers (709 citations)

What are the main themes of his work throughout his whole career to date?

Lawrence G. Lum focuses on Immunology, Cancer research, Internal medicine, Cell biology and Antibody. His studies deal with areas such as Cytotoxic T cell and Peripheral blood mononuclear cell as well as Immunology. His research in Cancer research focuses on subjects like T cell, which are connected to CD3.

His studies examine the connections between Internal medicine and genetics, as well as such issues in Gastroenterology, with regards to Cumulative incidence. Many of his studies involve connections with topics such as Tissue homeostasis and Cell biology. His work deals with themes such as Pokeweed mitogen, Antigen and Virology, which intersect with Antibody.

He most often published in these fields:

  • Immunology (40.09%)
  • Cancer research (21.15%)
  • Internal medicine (21.15%)

What were the highlights of his more recent work (between 2011-2019)?

  • Cancer research (21.15%)
  • Internal medicine (21.15%)
  • Immunology (40.09%)

In recent papers he was focusing on the following fields of study:

His main research concerns Cancer research, Internal medicine, Immunology, Cell biology and Wnt signaling pathway. His Cancer research research includes elements of Tumor microenvironment, Cancer, Breast cancer and Cytotoxicity. His Internal medicine study integrates concerns from other disciplines, such as Gastroenterology, Surgery and Oncology.

In his study, Granulocyte macrophage colony-stimulating factor and Cyclophosphamide is inextricably linked to Stem cell, which falls within the broad field of Immunology. His primary area of study in Cell biology is in the field of Signal transduction. Lawrence G. Lum has researched Wnt signaling pathway in several fields, including Cell signaling and Acyltransferase.

Between 2011 and 2019, his most popular works were:

  • In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. (163 citations)
  • Stromal–epithelial crosstalk regulates kidney progenitor cell differentiation (154 citations)
  • CRISPR-Cas9-based mutagenesis frequently provokes on-target mRNA misregulation (64 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Internal medicine

Lawrence G. Lum mostly deals with Cancer research, Wnt signaling pathway, Cell biology, Immunology and Immunotherapy. His work carried out in the field of Cancer research brings together such families of science as Breast cancer, Stem cell, Gene knockdown and RNA interference. The various areas that Lawrence G. Lum examines in his Wnt signaling pathway study include Cell signaling, Tissue homeostasis and Zebrafish.

The concepts of his Cell biology study are interwoven with issues in Cellular differentiation, Cancer cell, HEK 293 cells, Regulation of gene expression and Cell fate determination. His Immunology study incorporates themes from Peripheral blood mononuclear cell and Internal medicine, Transplantation. His Immunotherapy research integrates issues from Cell culture, T cell, Bispecific antibody, Monoclonal antibody and Interleukin 2.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

Rainer Storb;H. Joachim Deeg;John Whitehead;Frederick Appelbaum.
The New England Journal of Medicine (1986)

1553 Citations

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Baozhi Chen;Michael E. Dodge;Wei Tang;Jianming Lu.
Nature Chemical Biology (2009)

1459 Citations

The Hedgehog response network: sensors, switches, and routers.

Lawrence Lum;Philip A. Beachy.
Science (2004)

983 Citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

Lawrence Lum;Shenqin Yao;Brian Mozer;Alessandra Rovescalli.
Science (2003)

631 Citations

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

Lawrence Lum;Brian R. Wong;Régis Josien;J. David Becherer.
Journal of Biological Chemistry (1999)

613 Citations

Minimizing the risk of reporting false positives in large-scale RNAi screens

Christophe J Echeverri;Philip A Beachy;Buzz Baum;Michael Boutros.
Nature Methods (2006)

556 Citations

The kinetics of immune reconstitution after human marrow transplantation.

Lawrence G. Lum.
Blood (1987)

540 Citations

Leukemia of Large Granular Lymphocytes: Association with Clonal Chromosomal Abnormalities and Autoimmune Neutropenia, Thrombocytopenia, and Hemolytic Anemia

Thomas P. Loughran;Marshall E. Kadin;Gordon Starkebaum;Janis L. Abkowitz.
Annals of Internal Medicine (1985)

396 Citations

Prevalence of off-target effects in Drosophila RNA interference screens

Yong Ma;Adrian Creanga;Adrian Creanga;Lawrence Lum;Philip A. Beachy;Philip A. Beachy.
Nature (2006)

340 Citations

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.

Lawrence Lum;Chi Zhang;Sekyung Oh;Randall K. Mann.
Molecular Cell (2003)

298 Citations

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