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Biology and Biochemistry

D-Index
74
Citations
20545
World Ranking
5579
National Ranking
2651

Overview

Lawrence G. Lum is a researcher affiliated with the University of Virginia in the United States. Their work primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology as a subfield. Additional areas of study include Oncology, Genetics, Cell Biology, and Cancer Research.

The scientist's research encompasses significant topics such as Protein Degradation and Inhibitors, CRISPR and Genetic Engineering, Wnt/β-catenin signaling in development and cancer, Cancer-related gene regulation, PARP inhibition in cancer therapy, DNA Repair Mechanisms, and Genetics and Neurodevelopmental Disorders.

Lawrence G. Lum has contributed to multiple peer-reviewed publications, including:

  • Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1, 2020, Journal of Biological Chemistry
  • Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase, 2020, Cell Reports
  • Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities, 2023, Toxicological Sciences
  • Impact of CRISPR in cancer drug discovery, 2024, Science
  • Role of tankyrase scaffolding in the β-catenin destruction complex and WNT signaling, 2025, bioRxiv (Cold Spring Harbor Laboratory)

Coauthors frequently collaborating with Lawrence G. Lum include Ben Bolaños, Todd VanArsdale, Sherry Niessen, Martha A. Ornelas, and Jon A. Oyer.

Their work has been published in journals with a focus on biochemistry, molecular biology, toxicology, cell biology, and high-impact scientific research. Common venues of publication encompass the Journal of Biological Chemistry, Toxicological Sciences, Cell Reports, Science, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

    Rainer Storb;H. Joachim Deeg;John Whitehead;Frederick Appelbaum

  • Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

    Baozhi Chen;Michael E. Dodge;Wei Tang;Jianming Lu

  • The Hedgehog response network: sensors, switches, and routers.

    Lawrence Lum;Philip A. Beachy

  • Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

    Lawrence Lum;Shenqin Yao;Brian Mozer;Alessandra Rovescalli

  • Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

    Lawrence Lum;Brian R. Wong;Régis Josien;J. David Becherer

  • Minimizing the risk of reporting false positives in large-scale RNAi screens

    Christophe J Echeverri;Philip A Beachy;Buzz Baum;Michael Boutros

  • The kinetics of immune reconstitution after human marrow transplantation.

    Lawrence G. Lum

  • Leukemia of Large Granular Lymphocytes: Association with Clonal Chromosomal Abnormalities and Autoimmune Neutropenia, Thrombocytopenia, and Hemolytic Anemia

    Thomas P. Loughran;Marshall E. Kadin;Gordon Starkebaum;Janis L. Abkowitz

  • Prevalence of off-target effects in Drosophila RNA interference screens

    Yong Ma;Adrian Creanga;Adrian Creanga;Lawrence Lum;Philip A. Beachy;Philip A. Beachy

  • Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

    Courtney M. Karner;Amrita Das;Zhendong Ma;Michelle Self

  • Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.

    Lawrence Lum;Chi Zhang;Sekyung Oh;Randall K. Mann

  • Prospective comparative trial of autologous versus allogeneic bone marrow transplantation in patients with non-Hodgkin's lymphoma

    Voravit Ratanatharathorn;Joseph Uberti;Chatchada Karanes;Esteban Abella

  • The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation

    Shenqin Yao;Lawrence Lum;Philip Beachy

  • In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains.

    Enrico Moro;Gunes Ozhan-Kizil;Alessandro Mongera;Dimitris Beis

  • Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation

    Jan M. Agosti;Jay D. Sprenger;Lawrence G. Lum;Robert P. Witherspoon

  • Metargidin, a Membrane-anchored Metalloprotease-Disintegrin Protein with an RGD Integrin Binding Sequence

    Jörn Krätzschmar;Lawrence Lum;Carl P. Blobel

  • Immunologic reconstitution after human marrow grafting

    Witherspoon Rp;Lum Lg;Storb R

  • Stromal–epithelial crosstalk regulates kidney progenitor cell differentiation

    Amrita Das;Shunsuke Tanigawa;Courtney M. Karner;Courtney M. Karner;Mei Xin

  • Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15

    Lawrence Lum;Martha S. Reid;Carl P. Blobel

  • Extensive phosphorylation of Smoothened in Hedgehog pathway activation.

    Chi Zhang;Elizabeth H. Williams;Yurong Guo;Lawrence Lum

Frequent Co-Authors

Robert P. Witherspoon
Robert P. Witherspoon Fred Hutchinson Cancer Research Center
Philip A. Beachy
Philip A. Beachy Stanford University
Noelle S. Williams
Noelle S. Williams The University of Texas Southwestern Medical Center
Carl P. Blobel
Carl P. Blobel Cornell University
Rainer Storb
Rainer Storb Fred Hutchinson Cancer Research Center
E. Donnall Thomas
E. Donnall Thomas University of Washington
Keith M. Sullivan
Keith M. Sullivan Duke University
Jerry W. Shay
Jerry W. Shay The University of Texas Southwestern Medical Center
Woodring E. Wright
Woodring E. Wright The University of Texas Southwestern Medical Center
Jean E. Sanders
Jean E. Sanders Fred Hutchinson Cancer Research Center

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