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Molecular Biology

D-Index
60
Citations
9358
World Ranking
1987
National Ranking
988

Overview

Ales Cvekl is affiliated with the Albert Einstein College of Medicine in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Radiology, Nuclear Medicine and Imaging, Ophthalmology, Genetics, and Cancer Research.

The following topics characterize the main areas of work:

  • Connexins and lens biology
  • RNA regulation and disease
  • Heat shock proteins research
  • RNA Interference and Gene Delivery
  • Corneal surgery and disorders
  • Cancer-related gene regulation
  • RNA Research and Splicing

Ales Cvekl has published extensively in several venues, with notable frequent publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Experimental Eye Research
  • Epigenetics & Chromatin
  • Acta Ophthalmologica
  • Progress in Retinal and Eye Research

Their recent papers include:

  • "Cell fate decisions, transcription factors and signaling during early retinal development," 2022, Progress in Retinal and Eye Research
  • "Dynamic changes in whole genome DNA methylation, chromatin and gene expression during mouse lens differentiation," 2023, Epigenetics & Chromatin
  • "Aging of the eye: Lessons from cataracts and age-related macular degeneration," 2024, Ageing Research Reviews
  • "Crystallin gene expression: Insights from studies of transcriptional bursting," 2021, Experimental Eye Research
  • "Generation of Lens Progenitor Cells and Lentoid Bodies from Pluripotent Stem Cells: Novel Tools for Human Lens Development and Ocular Disease Etiology," 2022, Cells

Frequent collaborators in their research include:

  • Danielle Rayêe
  • Carolina Eliscovich
  • William K. Chang
  • Yilin Zhao
  • Cecília Gallottini de Magalhães

Best Publications

  • Anterior eye development and ocular mesenchyme: New insights from mouse models and human diseases

    Aleš Cvekl;Ernst R. Tamm

  • Lens development and crystallin gene expression: many roles for Pax-6

    Aleš Cvekl;Joram Piatigorsky

  • Programmed mitophagy is essential for the glycolytic switch during cell differentiation.

    Lorena Esteban‐Martínez;Elena Sierra‐Filardi;Rebecca S McGreal;María Salazar‐Roa

  • The cellular and molecular mechanisms of vertebrate lens development

    Aleš Cvekl;Ruth Ashery-Padan

  • Retinoic acid signaling in mammalian eye development.

    Ales Cvekl;Wei Lin Wang

  • Genetic and epigenetic mechanisms of gene regulation during lens development

    Ales Cvekl;Melinda K. Duncan

  • Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities.

    Daniela C Baulmann;Andreas Ohlmann;Cassandra Flügel-Koch;Sumanta Goswami

  • A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins.

    Aleš Cvekl;Christina M. Sax;Emery H. Bresnick;Joram Piatigorsky

  • DACH1 Inhibits Transforming Growth Factor-β Signaling through Binding Smad4

    Kongming Wu;Ying Yang;Chenguang Wang;Maria A. Davoli

  • Dual Roles for Pax-6: a Transcriptional Repressor of Lens Fiber Cell-Specific β-Crystallin Genes

    Melinda K. Duncan;John I. Haynes;Ales Cvekl;Joram Piatigorsky

  • PAX6: 25th anniversary and more to learn

    Ales Cvekl;Patrick Callaerts

  • Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression.

    Melinda K. Duncan;Zbynek Kozmik;Kveta Cveklova;Joram Piatigorsky

  • Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids.

    Sangbae Kim;Albert Lowe;Rachayata Dharmat;Seunghoon Lee

  • Pax-6 is essential for lens-specific expression of zeta-crystallin.

    Jill Richardson;Aleš Cvekl;Graeme Wistow

  • DACH1 Is a Cell Fate Determination Factor That Inhibits Cyclin D1 and Breast Tumor Growth

    Kongming Wu;Anping Li;Mahadev Rao;Manran Liu

  • Signaling and Gene Regulatory Networks in Mammalian Lens Development

    Ales Cvekl;Xin Zhang

  • Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site.

    Aleš Cvekl;Fatah Kashanchi;Christina M. Sax;John N. Brady

  • Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.

    Jian Sun;Shira Rockowitz;Qing Xie;Ruth Ashery-Padan

  • The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA.

    Jovica Ninkovic;Luisa Pinto;Stefania Petricca;Alexandra Lepier

  • Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene

    Ales Cvekl;Christina M. Sax;Xuan Li;Joan B. McDermott

Frequent Co-Authors

Joram Piatigorsky
Joram Piatigorsky National Institutes of Health
Deyou Zheng
Deyou Zheng Albert Einstein College of Medicine
Ernst R. Tamm
Ernst R. Tamm University of Regensburg
Jiri Zavadil
Jiri Zavadil International Agency For Research On Cancer
Eric F. Wawrousek
Eric F. Wawrousek National Institutes of Health
Richard G. Pestell
Richard G. Pestell The Wistar Institute
Kongming Wu
Kongming Wu Zhengzhou University
Arthur I. Skoultchi
Arthur I. Skoultchi Albert Einstein College of Medicine
Fatah Kashanchi
Fatah Kashanchi George Mason University
Magdalena Götz
Magdalena Götz Ludwig-Maximilians-Universität München

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