World's Best Scientists 2026 revealed!
Richard G. Pestell

Richard G. Pestell

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Biology and Biochemistry
USA
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
158
Citations
92558
World Ranking
131
National Ranking
97

Medicine

D-Index
160
Citations
96975
World Ranking
788
National Ranking
445

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Richard G. Pestell is affiliated with The Wistar Institute in the United States. Their research spans several interconnected fields within medical and molecular biology, emphasizing cancer research and related molecular mechanisms. The main fields of study for this scientist include Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on subfields such as Molecular Biology, Oncology, Cancer Research, Pulmonary and Respiratory Medicine, and Immunology.

Their work covers key topics including:

  • Cancer-related Molecular Pathways
  • Chemokine receptors and signaling
  • Immunotherapy and Immune Responses
  • MicroRNA in disease regulation
  • Cancer Mechanisms and Therapy
  • Prostate Cancer Treatment and Research
  • RNA modifications and cancer

Frequently collaborating with colleagues, Pestell has coauthored multiple papers with researchers such as Xuanmao Jiao, Anthony W. Ashton, Zhiping Li, Andrew V. Kossenkov, and Mathew C. Casimiro.

The scientist's publishing record includes numerous papers in notable venues, with repeat contributions to Cancer Research, International Journal of Molecular Sciences, UNC Libraries, Cell Reports, and Oncogene.

Representative recent publications include:

  • "piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer," 2021, Frontiers in Cell and Developmental Biology
  • "Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis," 2021, Journal of Clinical Investigation
  • "Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy," 2021, Breast Cancer Research
  • "CCR5-Mediated Signaling is Involved in Invasion of Glioblastoma Cells in Its Microenvironment," 2020, International Journal of Molecular Sciences
  • "Cyclin D1 promotes secretion of pro-oncogenic immuno-miRNAs and piRNAs," 2020, Clinical Science

The scientist has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) since 2011.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Stat3 as an Oncogene

    Jacqueline F Bromberg;Melissa H Wrzeszczynska;Geeta Devgan;Yanxiang Zhao

  • The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

    Michael Shtutman;Jacob Zhurinsky;Inbal Simcha;Chris Albanese

  • NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

    Denis C. Guttridge;Chris Albanese;Julie Y. Reuther;Richard G. Pestell

  • Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019

    Marissa B Reitsma;Parkes J Kendrick;Emad Ababneh;Cristiana Abbafati

  • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

    Stephanos Pavlides;Diana Whitaker-Menezes;Remedios Castello-Cros;Neal Flomenberg

  • Caveolin-1 Null Mice Are Viable but Show Evidence of Hyperproliferative and Vascular Abnormalities

    Babak Razani;Jeffery A. Engelman;Xiao Bo Wang;William Schubert

  • Cancer metabolism: a therapeutic perspective

    Ubaldo E Martinez-Outschoorn;Maria Peiris-Pagés;Richard G Pestell;Federica Sotgia;Federica Sotgia

  • Minireview: Cyclin D1: normal and abnormal functions.

    Maofu Fu;Chenguang Wang;Zhiping Li;Toshiyuki Sakamaki

  • Transforming p21ras Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

    Chris Albanese;Janet Johnson;Genichi Watanabe;Nathan Eklund

  • β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

    Shiaw Yih Lin;Weiya Xia;Jo C. Wang;Ka Yin Kwong

  • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

    Gloria Bonuccelli;Aristotelis Tsirigos;Diana Whitaker-Menezes;Stephanos Pavlides

  • Cancer Stem Cells

    Zuoren Yu;Timothy G. Pestell;Michael P. Lisanti;Richard G. Pestell

  • BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

    S. Fan;J.-A. Wang;R. Yuan;Y. Ma

  • Targeted downregulation of caveolin‐1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

    Ferruccio Galbiati;Daniela Volonté;Jeffrey A. Engelman;Genichi Watanabe

  • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

    Ubaldo E. Martinez-Outschoorn;Renee M. Balliet;Dayana B. Rivadeneira;Barbara Chiavarina

  • The mammary gland iodide transporter is expressed during lactation and in breast cancer

    Uygar H. Tazebay;Irene L. Wapnir;Orlie Levy;Orsolya Dohan

  • The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation.

    Latha Shivakumar;John D Minna;Toshiyuki Sakamaki;Richard Pestell

  • Opposing Action of Estrogen Receptors α and β on Cyclin D1 Gene Expression

    Meng-Min Liu;Chris Albanese;Carol M. Anderson;Kristin Hilty

  • Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.

    J K Westwick;Q T Lambert;G J Clark;M Symons

Frequent Co-Authors

Michael P. Lisanti
Michael P. Lisanti University of Salford
Chenguang Wang
Chenguang Wang Johns Hopkins University
Federica Sotgia
Federica Sotgia University of Salford
Chris Albanese
Chris Albanese Georgetown University Medical Center
Kongming Wu
Kongming Wu Zhengzhou University
Ubaldo E. Martinez-Outschoorn
Ubaldo E. Martinez-Outschoorn Thomas Jefferson University
Anthony Howell
Anthony Howell University of Manchester
Diana Whitaker-Menezes
Diana Whitaker-Menezes Thomas Jefferson University
Neal Flomenberg
Neal Flomenberg Thomas Jefferson University
Philippe G. Frank
Philippe G. Frank François Rabelais University

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