Philippe G. Frank focuses on Cell biology, Caveolae, Internal medicine, Endocrinology and Reverse Warburg effect. The concepts of his Cell biology study are interwoven with issues in Cell, Endocytosis, Albumin and Ligand. His Caveolae research integrates issues from Transcytosis, Caveolin 1, In vivo and Blood vessel.
In his work, Tumor progression and Metabolism is strongly intertwined with Cancer research, which is a subfield of Internal medicine. His work carried out in the field of Endocrinology brings together such families of science as CD36 and Atheroma. While the research belongs to areas of Reverse Warburg effect, Philippe G. Frank spends his time largely on the problem of Stromal cell, intersecting his research to questions surrounding Cancer-Associated Fibroblasts.
Cell biology, Caveolae, Caveolin 1, Cholesterol and Internal medicine are his primary areas of study. His studies examine the connections between Cell biology and genetics, as well as such issues in Cell, with regards to Cell growth. Many of his research projects under Caveolae are closely connected to Cellular differentiation with Cellular differentiation, tying the diverse disciplines of science together.
His Caveolin 1 study combines topics in areas such as Apoptosis, Sphingolipid, Signal transduction and Homeostasis. His work in Cholesterol addresses subjects such as Efflux, which are connected to disciplines such as Phospholipid efflux. His Internal medicine research includes themes of Endocrinology, Oncology and Cancer research.
The scientist’s investigation covers issues in Cancer research, Cancer, Cholesterol, Breast cancer and Caveolin 1. The Cancer research study combines topics in areas such as Cell migration, Cancer cell, Scavenger receptor, Signal transduction and Docetaxel. His Cancer research is included under the broader classification of Internal medicine.
Cholesterol is the subject of his research, which falls under Biochemistry. His research integrates issues of Inflammation and Caveolae, Caveolin in his study of Caveolin 1. Philippe G. Frank has researched Caveolae in several fields, including Transcytosis, Endothelium and Lipoprotein.
Philippe G. Frank mostly deals with Cancer research, Signal transduction, Cancer cell, Cell biology and Scavenger receptor. The study incorporates disciplines such as MAPK/ERK pathway, Biochemistry, Foam cell, RHOA and Metastasis Suppressor Gene in addition to Cancer research. He combines subjects such as Lipid metabolism, Internal medicine, Reverse cholesterol transport and Phosphodiesterase with his study of Signal transduction.
His studies in Cancer cell integrate themes in fields like Cell migration, Extracellular, Metastasis, Intracellular and Breast cancer. In general Cell biology study, his work on Caveolin 1 and Caveolae often relates to the realm of Vascular endothelial growth factor B, thereby connecting several areas of interest. His Scavenger receptor study integrates concerns from other disciplines, such as Cancer, Cell signaling, Protein kinase B, Protein kinase A and PI3K/AKT/mTOR pathway.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
Stephanos Pavlides;Diana Whitaker-Menezes;Remedios Castello-Cros;Neal Flomenberg.
Cell Cycle (2009)
Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities
Babak Razani;Terry P. Combs;Xiao Bo Wang;Philippe G. Frank.
Journal of Biological Chemistry (2002)
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
Gloria Bonuccelli;Aristotelis Tsirigos;Diana Whitaker-Menezes;Stephanos Pavlides.
Cell Cycle (2010)
Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice.
William Schubert;Philippe G. Frank;Scott E. Woodman;Hideyuki Hyogo.
Journal of Biological Chemistry (2002)
Caveolin, Caveolae, and Endothelial Cell Function
Philippe G. Frank;Scott E. Woodman;David S. Park;Michael P. Lisanti.
Arteriosclerosis, Thrombosis, and Vascular Biology (2003)
Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo.
William Schubert;Philippe G. Frank;Babak Razani;David S. Park.
Journal of Biological Chemistry (2001)
Apolipoprotein A-I: structure–function relationships
Philippe G. Frank;Yves L. Marcel.
Journal of Lipid Research (2000)
Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.
Ferruccio Galbiati;Daniela Volonte;Jun Liu;Franco Capozza.
Molecular Biology of the Cell (2001)
Role of cholesterol in the development and progression of breast cancer
Gemma Llaverias;Christiane Danilo;Isabelle Mercier;Kristin Daumer.
American Journal of Pathology (2011)
Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation
Stephanos Pavlides;Aristotelis Tsirigos;Iset Vera;Neal Flomenberg.
Cell Cycle (2010)
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