Philippe G. Frank

Overview

Best Publications

• The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

  Stephanos Pavlides;Diana Whitaker-Menezes;Remedios Castello-Cros;Neal Flomenberg

  1454
  Citations

• Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

  Gloria Bonuccelli;Aristotelis Tsirigos;Diana Whitaker-Menezes;Stephanos Pavlides

  711
  Citations

• Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

  Babak Razani;Terry P. Combs;Xiao Bo Wang;Philippe G. Frank

  710
  Citations

• Caveolin, Caveolae, and Endothelial Cell Function

  Philippe G. Frank;Scott E. Woodman;David S. Park;Michael P. Lisanti

  471
  Citations

• Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice.

  William Schubert;Philippe G. Frank;Scott E. Woodman;Hideyuki Hyogo

  451
  Citations

• Apolipoprotein A-I: structure–function relationships

  Philippe G. Frank;Yves L. Marcel

  404
  Citations

• Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo.

  William Schubert;Philippe G. Frank;Babak Razani;David S. Park

  398
  Citations

• Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

  Ferruccio Galbiati;Daniela Volonte;Jun Liu;Franco Capozza

  356
  Citations

• Role of cholesterol in the development and progression of breast cancer

  Gemma Llaverias;Christiane Danilo;Isabelle Mercier;Kristin Daumer

  344
  Citations

• Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

  Stephanos Pavlides;Aristotelis Tsirigos;Iset Vera;Neal Flomenberg

  301
  Citations

• Caveolin-1 Promotes Tumor Progression in an Autochthonous Mouse Model of Prostate Cancer: Genetic Ablation of Cav-1 Delays Advanced Prostate Tumor Development in Tramp Mice

  T.M. Williams;G.S. Hassan;J. Li;A.W. Cohen

  287
  Citations

• The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

  Stephanos Pavlides;Aristotelis Tsirigos;Gemma Migneco;Diana Whitaker-Menezes

  282
  Citations

• Apolipoprotein A-I Conformation in Reconstituted Discoidal Lipoproteins Varying in Phospholipid and Cholesterol Content

  Jean Bergeron;Philippe G. Frank;Damon Scales;Qiang-Hua Meng

  274
  Citations

• Genetic Ablation of Caveolin-1 Confers Protection Against Atherosclerosis

  Philippe G. Frank;Hyangkyu Lee;David S. Park;Narendra N. Tandon

  274
  Citations

• Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.

  David S. Park;Scott E. Woodman;William Schubert;Alex W. Cohen

  267
  Citations

• The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

  Gloria Bonuccelli;Diana Whitaker-Menezes;Remedios Castello-Cros;Stephanos Pavlides

  250
  Citations

• Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling".

  Stephanos Pavlides;Aristotelis Tsirigos;Iset Medina Vera;Neal Flomenberg

  199
  Citations

• Caveolin-1 and regulation of cellular cholesterol homeostasis.

  Philippe G. Frank;Michelle W.-C. Cheung;Stephanos Pavlides;Gemma Llaverias

  194
  Citations

• Caveolae and transcytosis in endothelial cells: role in atherosclerosis

  Philippe G. Frank;Stephanos Pavlides;Michael P. Lisanti

  191
  Citations

• ICAM-1: role in inflammation and in the regulation of vascular permeability.

  Philippe G. Frank;Michael P. Lisanti

  190
  Citations