World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
104
Citations
50422
World Ranking
6946
National Ranking
674

Overview

Federica Sotgia is a researcher affiliated with the University of Salford in the United Kingdom. Their academic contributions primarily focus on biochemistry, genetics, and molecular biology, with additional work in the field of medicine. Their research spans several interconnected subfields, including molecular biology, cancer research, oncology, infectious diseases, and cell biology.

The main topics investigated by Sotgia include mitochondrial function and pathology, cancer-related processes such as hypoxia and metabolism, cancer cell biology and metastasis, ATP synthase and ATPases research, RNA modifications in cancer, epigenetics and DNA methylation, as well as clinical studies related to COVID-19.

Frequent publication venues where Sotgia's work appears include Aging, Cells, Frontiers in Oncology, Cell Death and Differentiation, and Cell Death and Disease. The number of publications in these journals indicates a focus particularly strong on Aging and Cells.

Recent notable papers authored or co-authored by Sotgia include:

  • COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection?, 2020, Aging
  • High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy, 2021, Frontiers in Oncology
  • Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase, 2021, Cell Death and Differentiation
  • Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway, 2020, Cells
  • Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production, 2020, Cells

Sotgia has collaborated frequently with several co-authors, notably Michael P. Lisanti, Marco Fiorillo, Béla Ózsvári, Matteo Brindisi, and Zahra Moftakhar. These collaborations reflect ongoing research efforts within the fields of cancer biology and mitochondrial dysfunction.

The distribution of research output shows a focus on molecular mechanisms underlying disease, particularly cancer and aging, as well as therapeutic strategies targeting mitochondrial metabolism.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

    Stephanos Pavlides;Diana Whitaker-Menezes;Remedios Castello-Cros;Neal Flomenberg

  • Cancer metabolism: a therapeutic perspective

    Ubaldo E Martinez-Outschoorn;Maria Peiris-Pagés;Richard G Pestell;Federica Sotgia;Federica Sotgia

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy.

    Carlo Minetti;Federica Sotgia;Claudio Bruno;Claudio Bruno;Paolo Scartezzini

  • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

    Gloria Bonuccelli;Aristotelis Tsirigos;Diana Whitaker-Menezes;Stephanos Pavlides

  • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

    Ubaldo E. Martinez-Outschoorn;Renee M. Balliet;Dayana B. Rivadeneira;Barbara Chiavarina

  • Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types : treating cancer like an infectious disease

    Rebecca Lamb;Bela Ozsvari;Camilla L. Lisanti;Herbert B. Tanowitz

  • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

    Ubaldo E Martinez-Outschoorn;Casey Trimmer;Zhao Lin;Diana Whitaker-Menezes

  • Cancer stem cell metabolism

    Maria Peiris-Pagès;Ubaldo E. Martinez-Outschoorn;Richard G. Pestell;Federica Sotgia

  • Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Zhao Lin;Adam Ertel

  • Ketones and lactate increase cancer cell “stemness”, driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics

    Ubaldo E. Martinez-Outschoorn;Marco Prisco;Adam Ertel;Aristotelis Tsirigos

  • Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth.

    Ubaldo E. Martinez-Outschoorn;Michael P. Lisanti;Federica Sotgia

  • Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

    Carmela Guido;Diana Whitaker-Menezes;Claudia Capparelli;Renee Balliet

  • Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Neal Flomenberg;Ruth C. Birbe

  • Role of cholesterol in the development and progression of breast cancer

    Gemma Llaverias;Christiane Danilo;Isabelle Mercier;Kristin Daumer

  • An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

    Agnieszka K. Witkiewicz;Abhijit Dasgupta;Federica Sotgia;Isabelle Mercier

  • Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

    Ubaldo E. Martinez-Outschoorn;Stephanos Pavlides;Diana Whitaker-Menezes;Kristin M. Daumer

  • Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

    Federica Sotgia;Ubaldo E. Martinez-Outschoorn;Anthony Howell;Richard G. Pestell

Frequent Co-Authors

Michael P. Lisanti
Michael P. Lisanti University of Salford
Richard G. Pestell
Richard G. Pestell The Wistar Institute
Ubaldo E. Martinez-Outschoorn
Ubaldo E. Martinez-Outschoorn Thomas Jefferson University
Anthony Howell
Anthony Howell University of Manchester
Diana Whitaker-Menezes
Diana Whitaker-Menezes Thomas Jefferson University
Carlo Minetti
Carlo Minetti University of Genoa
Neal Flomenberg
Neal Flomenberg Thomas Jefferson University
Philippe G. Frank
Philippe G. Frank François Rabelais University
Chenguang Wang
Chenguang Wang Johns Hopkins University
Claudio Bruno
Claudio Bruno Istituto Giannina Gaslini

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring medicine in the USA opens up a range of online degree options and career pathways in health care. Professionals looking to advance quickly might consider pursuing a health care administration degree, which can prepare you for leadership roles in various medical settings.

Registered nurses interested in furthering their clinical expertise often look into rn to fnp programs. These bridge programs allow RNs to earn their Family Nurse Practitioner certification efficiently and entirely online, opening doors to greater responsibility and autonomy.

For those passionate about diet, wellness, and disease prevention, online nutrition degree programs offer flexible options to specialize in the growing field of nutritional science.

If your goal is to move into senior healthcare management, consider cahme accredited online mha programs. These degrees are widely respected and can help you build the skills needed to lead hospitals or large clinical organizations.

Each path provides a unique opportunity to impact healthcare and tailor your career to your interests and schedule.

Best Scientists Citing Federica Sotgia

Trending Scientists

Recently Published Articles