World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
13806
World Ranking
14270
National Ranking
6018

Overview

Diana Whitaker-Menezes is affiliated with Thomas Jefferson University in the United States and has contributed extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research spans multiple subfields, including Cancer Research, Oncology, Molecular Biology, Immunology, and Rheumatology.

The scientist's recent publications include studies addressing mechanisms of cancer aggressiveness, inflammatory interactions in kidney disease, and metabolic reprogramming in cancer. Specific papers include:

  • Translocase of the outer mitochondrial membrane complex subunit 20 (TOMM20) facilitates cancer aggressiveness and therapeutic resistance in chondrosarcoma (2020), published in Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  • Macrophage and adipocyte interaction as a source of inflammation in kidney disease (2021), published in Scientific Reports
  • 4NQO induced carcinogenesis: A mouse model for oral squamous cell carcinoma (2021), published in Methods in Cell Biology
  • TP53 Induced Glycolysis and Apoptosis Regulator and Monocarboxylate Transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer (2023), published in International Journal of Cancer
  • Uremic Myopathy and Mitochondrial Dysfunction in Kidney Disease (2022), published in International Journal of Molecular Sciences

The main topics covered by Whitaker-Menezes's work include:

  • Cancer, Hypoxia, and Metabolism
  • Cancer Immunotherapy and Biomarkers
  • Cancer-related molecular mechanisms research
  • Metabolism, Diabetes, and Cancer
  • Interferon and immune responses
  • Cancer Diagnosis and Treatment
  • Bone Tumor Diagnosis and Treatments

Frequent coauthors collaborating with Whitaker-Menezes are:

  • Ubaldo Martinez-Outschoorn
  • Megan Roche
  • Joseph Curry
  • Madalina Tuluc
  • Marina Domingo-Vidal

Whitaker-Menezes's work is regularly published in journals such as Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, International Journal of Cancer, Scientific Reports, Methods in Cell Biology, and International Journal of Molecular Sciences.

Best Publications

  • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

    Stephanos Pavlides;Diana Whitaker-Menezes;Remedios Castello-Cros;Neal Flomenberg

  • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

    Gloria Bonuccelli;Aristotelis Tsirigos;Diana Whitaker-Menezes;Stephanos Pavlides

  • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

    Ubaldo E. Martinez-Outschoorn;Renee M. Balliet;Dayana B. Rivadeneira;Barbara Chiavarina

  • Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

    Peter J. Koch;M G. Mahoney;Hiroyasu Ishikawa;Leena Pulkkinen

  • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

    Ubaldo E Martinez-Outschoorn;Casey Trimmer;Zhao Lin;Diana Whitaker-Menezes

  • Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Zhao Lin;Adam Ertel

  • Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

    Carmela Guido;Diana Whitaker-Menezes;Claudia Capparelli;Renee Balliet

  • Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Neal Flomenberg;Ruth C. Birbe

  • Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

    Ubaldo E. Martinez-Outschoorn;Stephanos Pavlides;Diana Whitaker-Menezes;Kristin M. Daumer

  • Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis.

    Stephanos Pavlides;Iset Vera;Ricardo Gandara;Sharon Sneddon

  • Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".

    Michael P Lisanti;Ubaldo E Martinez-Outschoorn;Zhao Lin;Stephanos Pavlides

  • The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

    Stephanos Pavlides;Aristotelis Tsirigos;Gemma Migneco;Diana Whitaker-Menezes

  • HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.

    Barbara Chiavarina;Diana Whitaker-Menezes;Gemma Migneco;Ubaldo E. Martinez-Outschoorn

  • Using the “reverse Warburg effect” to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

    Agnieszka K. Witkiewicz;Diana Whitaker-Menezes;Abhijit Dasgupta;Nancy J. Philp

  • Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.

    Claudia Capparelli;Carmela Guido;Diana Whitaker-Menezes;Gloria Bonuccelli

  • CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.

    Claudia Capparelli;Barbara Chiavarina;Diana Whitaker-Menezes;Timothy G. Pestell

  • The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

    Gloria Bonuccelli;Diana Whitaker-Menezes;Remedios Castello-Cros;Stephanos Pavlides

  • Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer

    Joseph M. Curry;Madalina Tuluc;Diana Whitaker-Menezes;Julie A. Ames

  • Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment.

    Michael P. Lisanti;Ubaldo E. Martinez-Outschoorn;Barbara Chiavarina;Stephanos Pavlides

  • Ketone body utilization drives tumor growth and metastasis

    Ubaldo E. Martinez-Outschoorn;Zhao Lin;Diana Whitaker-Menezes;Anthony Howell

Frequent Co-Authors

Michael P. Lisanti
Michael P. Lisanti University of Salford
Federica Sotgia
Federica Sotgia University of Salford
Anthony Howell
Anthony Howell University of Manchester
Richard G. Pestell
Richard G. Pestell The Wistar Institute
George F. Murphy
George F. Murphy Brigham and Women's Hospital
Neal Flomenberg
Neal Flomenberg Thomas Jefferson University
Aristotelis Tsirigos
Aristotelis Tsirigos New York University
Agnieszka K. Witkiewicz
Agnieszka K. Witkiewicz Roswell Park Cancer Institute
Chenguang Wang
Chenguang Wang Johns Hopkins University
Robert Korngold
Robert Korngold Hackensack University Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology or Biochemistry in the USA provides a strong foundation for diverse careers in healthcare, research, and education. Many graduates seek to advance their careers with further qualifications or pursue specialized roles.

For those interested in nursing, completing one of the cheapest rn to bsn online programs can be a cost-effective way to progress from an RN to a Bachelor of Science in Nursing. Students drawn to leadership roles in medicine might explore an online masters healthcare management program, which is designed to prepare graduates for management and administrative positions in healthcare organizations.

Another popular pathway is psychiatric nursing. For those seeking advanced practice, consider the psychiatric np programs available online, which enable registered nurses to specialize in mental health care. Nutrition is also a growing field, and students with a background in biology or biochemistry may wish to enroll in accelerated dietitian programs to quickly enter the nutrition and wellness sector.

These pathways offer flexibility and specialized training, making it possible to build rewarding careers that bridge science and healthcare.

Best Scientists Citing Diana Whitaker-Menezes

Trending Scientists