World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
23501
World Ranking
4518
National Ranking
2198

Medicine

D-Index
79
Citations
23851
World Ranking
17519
National Ranking
8767

Overview

Agnieszka K. Witkiewicz is affiliated with the Roswell Park Cancer Institute in the United States. Their research primarily focuses on the intersection of medicine, biochemistry, genetics, and molecular biology with a strong emphasis on oncology and cancer-related fields.

The scientist has contributed extensively to studies in multiple subfields including oncology, pulmonary and respiratory medicine, cancer research, molecular biology, and immunology. Their work addresses a range of topics such as advanced breast cancer therapies, cancer-related molecular pathways, breast cancer treatment studies, HER2/EGFR in cancer research, pancreatic and hepatic oncology research, lung cancer research studies, and cancer genomics and diagnostics.

Recent notable publications by Agnieszka K. Witkiewicz include:

  • Binary pan-cancer classes with distinct vulnerabilities defined by pro- or anti-cancer YAP/TEAD activity (2021, Cancer Cell)
  • CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities (2022, Cell Reports)
  • Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity (2020, Clinical Cancer Research)
  • Pan-cancer molecular analysis of the RB tumor suppressor pathway (2020, Communications Biology)
  • Functional Determinants of Cell Cycle Plasticity and Sensitivity to CDK4/6 Inhibition (2020, Cancer Research)

Witkiewicz frequently collaborates with several researchers, including:

  • Erik S. Knudsen
  • Jianxin Wang
  • Vishnu Kumarasamy
  • Carsten Denkert
  • Angela DeMichele

Key venues where Witkiewicz's work has been published include:

  • Cancer Research
  • UNC Libraries
  • Cell Reports
  • Clinical Cancer Research
  • Oncogene

Best Publications

  • The history and future of targeting cyclin-dependent kinases in cancer therapy

    Uzma Asghar;Agnieszka K. Witkiewicz;Nicholas C. Turner;Erik S. Knudsen

  • The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

    Stephanos Pavlides;Diana Whitaker-Menezes;Remedios Castello-Cros;Neal Flomenberg

  • Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

    Agnieszka Witkiewicz;Elizabeth A. McMillan;Uthra Balaji;GuemHee Baek

  • Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

    Cristovão M. Sousa;Douglas E. Biancur;Xiaoxu Wang;Christopher J. Halbrook

  • Acetate dependence of tumors.

    Sarah A Comerford;Zhiguang Huang;Xinlin Du;Yun Wang

  • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells

    Ubaldo E. Martinez-Outschoorn;Renee M. Balliet;Dayana B. Rivadeneira;Barbara Chiavarina

  • Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

    Kirsten L. Bryant;Clint A. Stalnecker;Daniel Zeitouni;Jennifer E. Klomp

  • Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

    Eric Londina;Phillipe Lohera;Aristeidis G. Telonis;Kevin Quann

  • Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

    Ubaldo E Martinez-Outschoorn;Casey Trimmer;Zhao Lin;Diana Whitaker-Menezes

  • Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Zhao Lin;Adam Ertel

  • The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression

    Ankur Sharma;Wen Shuz Yeow;Adam Ertel;Ilsa Coleman

  • Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Neal Flomenberg;Ruth C. Birbe

  • An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

    Agnieszka K. Witkiewicz;Abhijit Dasgupta;Federica Sotgia;Isabelle Mercier

  • Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

    Ubaldo E. Martinez-Outschoorn;Stephanos Pavlides;Diana Whitaker-Menezes;Kristin M. Daumer

  • Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer

    Chellappagounder Thangavel;Jeffry L Dean;Adam Ertel;Karen E Knudsen

  • The meaning of p16(ink4a) expression in tumors: functional significance, clinical associations and future developments.

    Agnieszka K. Witkiewicz;Karen E. Knudsen;Adam P. Dicker;Erik S. Knudsen

  • The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies.

    Erik S. Knudsen;Agnieszka K. Witkiewicz

  • Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

    Ethan V. Abel;Kevin J. Basile;Curtis H. Kugel;Agnieszka K. Witkiewicz

  • Using the “reverse Warburg effect” to identify high-risk breast cancer patients: Stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers

    Agnieszka K. Witkiewicz;Diana Whitaker-Menezes;Abhijit Dasgupta;Nancy J. Philp

  • The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

    Gloria Bonuccelli;Diana Whitaker-Menezes;Remedios Castello-Cros;Stephanos Pavlides

Frequent Co-Authors

Jonathan R. Brody
Jonathan R. Brody Thomas Jefferson University
Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Michael P. Lisanti
Michael P. Lisanti University of Salford
Federica Sotgia
Federica Sotgia University of Salford
Hallgeir Rui
Hallgeir Rui Medical College of Wisconsin
Diana Whitaker-Menezes
Diana Whitaker-Menezes Thomas Jefferson University
Paolo Fortina
Paolo Fortina Thomas Jefferson University
Richard G. Pestell
Richard G. Pestell The Wistar Institute
Anthony Howell
Anthony Howell University of Manchester
Ubaldo E. Martinez-Outschoorn
Ubaldo E. Martinez-Outschoorn Thomas Jefferson University

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