John M. Asara spends much of his time researching Cell biology, Biochemistry, Phosphorylation, Cancer research and Signal transduction. The study incorporates disciplines such as Molecular biology and Cell growth in addition to Cell biology. His Phosphorylation study frequently intersects with other fields, such as PI3K/AKT/mTOR pathway.
His Cancer research research includes elements of Autophagy, Cancer, Pancreatic cancer, KRAS and MAPK/ERK pathway. His studies deal with areas such as Cell cycle, Kinase and Pyrimidine metabolism as well as Signal transduction. His study in PKM2 is interdisciplinary in nature, drawing from both Pyruvate dehydrogenase kinase and Pyruvate dehydrogenase phosphatase.
John M. Asara focuses on Cell biology, Cancer research, Biochemistry, Phosphorylation and Molecular biology. His research on Cell biology often connects related topics like Autophagy. His study on Cancer research also encompasses disciplines like
His works in Glycolysis, Pyruvate kinase, Biosynthesis, Oxidative stress and Serine are all subjects of inquiry into Biochemistry. His Phosphorylation study frequently involves adjacent topics like Kinase. His work deals with themes such as TSC2 and Transcription factor, which intersect with mTORC1.
His primary areas of study are Cell biology, Cancer research, mTORC1, Cancer cell and Autophagy. All of his Cell biology and Kinase and Phosphorylation investigations are sub-components of the entire Cell biology study. His work carried out in the field of Cancer research brings together such families of science as Cancer, Breast cancer, Triple-negative breast cancer, Glycolysis and Lung cancer.
His mTORC1 study also includes
Cell biology, Cancer research, Signal transduction, Kinase and Cancer cell are his primary areas of study. His Cell biology study incorporates themes from Inflammation and Innate immune system, Immune system. The Cancer research study combines topics in areas such as Cancer, Breast cancer, Adenocarcinoma, Transcriptome and KRAS.
His Signal transduction research integrates issues from Vibrio cholerae, Bacteria, Host and Microbiology. His studies deal with areas such as mTORC1, Autophagy, TFEB and Phosphorylation as well as Kinase. His research investigates the link between Cancer cell and topics such as Glycolysis that cross with problems in Oxidative phosphorylation and Fumarase.
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing
Mircea Ivan;Keiichi Kondo;Haifeng Yang;William Y. Kim.
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan;David B. Shackelford;Maria M. Mihaylova;Sara R. Gelino.
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Haoqiang Ying;Alec C. Kimmelman;Costas A. Lyssiotis;Sujun Hua.
Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway
Jaekyoung Son;Costas A. Lyssiotis;Costas A. Lyssiotis;Haoqiang Ying;Xiaoxu Wang.
Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation
Hiroyuki Sano;Susan Kane;Eiko Sano;Cristinel P. Mı̂inea.
Journal of Biological Chemistry (2003)
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk;Matthew G. Vander Heiden;Ning Wu;John M. Asara;John M. Asara.
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
Dimitrios Anastasiou;Dimitrios Anastasiou;George Poulogiannis;George Poulogiannis;John M. Asara;John M. Asara;Matthew B. Boxer.
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
Valerie S. LeBleu;Joyce T. O’Connell;Karina N. Gonzalez Herrera;Harriet Wikman.
Nature Cell Biology (2014)
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis.
Nature Genetics (2011)
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Andrea Viale;Piergiorgio Pettazzoni;Costas A. Lyssiotis;Haoqiang Ying.
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