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Molecular Biology

D-Index
120
Citations
64894
World Ranking
257
National Ranking
150

Overview

John M. Asara is affiliated with Beth Israel Deaconess Medical Center in the United States and has a research profile centered on biochemistry, genetics, and molecular biology, with significant contributions in medicine.

Their research work spans several subfields including molecular biology, cancer research, oncology, immunology, and physiology.

Core topics investigated by John M. Asara include:

  • Cancer, hypoxia, and metabolism
  • Epigenetics and DNA methylation
  • RNA modifications and cancer
  • Metabolism, diabetes, and cancer
  • Cancer, lipids, and metabolism
  • PI3K/AKT/mTOR signaling in cancer
  • Biochemical and molecular research

Their recent publications feature research on cancer metabolism, immunology, and tumor progression, including the following papers:

  • Targeted deletion of PD-1 in myeloid cells induces antitumor immunity (2020, Science Immunology)
  • Fatty acid synthesis is required for breast cancer brain metastasis (2021, Nature Cancer)
  • Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer (2020, Cell Reports)
  • Age-induced accumulation of methylmalonic acid promotes tumour progression (2020, Nature)
  • GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis (2021, Nature Communications)

John M. Asara frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Metabolism
  • Cancer Research
  • Cell Reports

The scientist has collaborated extensively with multiple coauthors, among whom are:

  • Min Yuan
  • Lewis C. Cantley
  • Norbert Perrimon
  • Wenyi Wei
  • Issam Ben-Sahra

Best Publications

  • HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

    Mircea Ivan;Keiichi Kondo;Haifeng Yang;William Y. Kim

  • Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

    Daniel F. Egan;David B. Shackelford;Maria M. Mihaylova;Sara R. Gelino

  • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

    Haoqiang Ying;Alec C. Kimmelman;Costas A. Lyssiotis;Sujun Hua

  • Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway

    Jaekyoung Son;Costas A. Lyssiotis;Costas A. Lyssiotis;Haoqiang Ying;Xiaoxu Wang

  • PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

    Valerie S. LeBleu;Joyce T. O’Connell;Karina N. Gonzalez Herrera;Harriet Wikman

  • Insulin-stimulated Phosphorylation of a Rab GTPase-activating Protein Regulates GLUT4 Translocation

    Hiroyuki Sano;Susan Kane;Eiko Sano;Cristinel P. Mı̂inea

  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  • Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

    Dimitrios Anastasiou;Dimitrios Anastasiou;George Poulogiannis;George Poulogiannis;John M. Asara;John M. Asara;Matthew B. Boxer

  • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

    Andrea Viale;Piergiorgio Pettazzoni;Costas A. Lyssiotis;Haoqiang Ying

  • Pyruvate kinase M2 is a phosphotyrosine-binding protein

    Heather R. Christofk;Matthew G. Vander Heiden;Ning Wu;John M. Asara;John M. Asara

  • A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

    Min Yuan;Susanne B Breitkopf;Xuemei Yang;John M Asara;John M Asara

  • Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

    Cristovão M. Sousa;Douglas E. Biancur;Xiaoxu Wang;Christopher J. Halbrook

  • An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

    Jennifer R. Molina;Yuting Sun;Marina Protopopova;Sonal Gera

  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

    Jihye Yun;Edouard Mullarky;Edouard Mullarky;Changyuan Lu;Kaitlyn N. Bosch

  • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

    Dimitrios Anastasiou;Yimin Yu;William James Israelsen;Jian-Kang Jiang

  • Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

    Matthew G. Vander Heiden;Matthew G. Vander Heiden;Jason W. Locasale;Jason W. Locasale;Kenneth D. Swanson;Hadar Sharfi

  • Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

    Issam Ben-Sahra;Jessica J. Howell;John M. Asara;Brendan D. Manning

  • mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

    Issam Ben-Sahra;Gerta Hoxhaj;Stéphane J. H. Ricoult;John M. Asara

  • Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

    Matthew G. Vander Heiden;Dimitrios Anastasiou;George Poulogiannis;John M. Asara

  • Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    J. Locasale;J. Locasale;Alexandra Grassian;Rameen Beroukhim;Matthew Langer Meyerson

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
Norbert Perrimon
Norbert Perrimon Harvard University
Jason W. Locasale
Jason W. Locasale Duke University
Brendan D. Manning
Brendan D. Manning Harvard University
Alec C. Kimmelman
Alec C. Kimmelman New York University
Wenyi Wei
Wenyi Wei Beth Israel Deaconess Medical Center
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
Christoph W. Turck
Christoph W. Turck Max Planck Society

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