Peter J. Ratcliffe

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
• 2019 - Nobel Prize for their discoveries of how cells sense and adapt to oxygen availability
• 2017 - Buchanan Medal, Royal Society (UK) for his ground-breaking research on oxygen sensing and signalling pathways mediating cellular responses to hypoxia".
• 2016 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
• 2012 - Robert J. and Claire Pasarow Foundation Medical Research Award
• 2010 - Canada Gairdner International Award
• 2007 - Fellow of the American Academy of Arts and Sciences
• 2002 - Fellow of the Royal Society, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Member of the Association of American Physicians
• Fellow of The Academy of Medical Sciences, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Member of the Association of American Physicians
• Fellow of The Academy of Medical Sciences, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Member of the Association of American Physicians
• Fellow of The Academy of Medical Sciences, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Member of the Association of American Physicians
• Fellow of The Academy of Medical Sciences, United Kingdom
• Member of the European Molecular Biology Organization (EMBO)
• Member of the Association of American Physicians
• Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Best Publications

• Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  Panu Jaakkola;David R. Mole;Ya-Min Tian;Michael I. Wilson

  6751
  Citations

• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

  Patrick H. Maxwell;Michael S. Wiesener;Gin-Wen Chang;Steven C. Clifford

  6131
  Citations

• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

  Andrew C.R. Epstein;Jonathan M. Gleadle;Luke A. McNeill;Kirsty S. Hewitson

  4108
  Citations

• Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

  William G. Kaelin;Peter J. Ratcliffe

  4054
  Citations

• Regulation of angiogenesis by hypoxia: role of the HIF system.

  Christopher W Pugh;Peter J Ratcliffe

  3434
  Citations

• Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.

  Peter Carmeliet;Yuval Dor;Jean-Marc Herbert;Dai Fukumura

  3339
  Citations

• Oxygen sensing by HIF hydroxylases

  Christopher J. Schofield;Peter J. Ratcliffe

  2938
  Citations

• The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages

  Katherine L. Talks;Helen Turley;Kevin C. Gatter;Patrick H. Maxwell

  1742
  Citations

• Hypoxia-inducible Expression of Tumor-associated Carbonic Anhydrases

  Charles C. Wykoff;Nigel J. P. Beasley;Peter H. Watson;Kevin J. Turner

  1564
  Citations

• Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

  P H Maxwell;G U Dachs;J M Gleadle;L G Nicholls

  1402
  Citations

• Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

  Matthew E. Cockman;Norma Masson;David R. Mole;Panu Jaakkola

  1374
  Citations

• Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

  Norma Masson;Carsten Willam;Patrick H. Maxwell;Christopher W. Pugh

  1348
  Citations

• Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor *

  Rebecca J. Appelhoff;Ya-Min Tian;Raju R. Raval;Helen Turley

  1323
  Citations

• HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

  Jennifer S. Isaacs;Yun Jin Jung;David R. Mole;Sunmin Lee

  1263
  Citations

• The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

  Rasheduzzaman Chowdhury;Kar Kheng Yeoh;Ya-Min Tian;Lars Hillringhaus

  1171
  Citations

• Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

  Raju R. Raval;Kah Weng Lau;Maxine G. B. Tran;Heidi M. Sowter

  1165
  Citations

• Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.

  Michael S Wiesener;Jan Steffen Jürgensen;Christian Rosenberger;Charlotte K Scholze

  986
  Citations

• Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

  Massimiliano Mazzone;Massimiliano Mazzone;Daniela Dettori;Daniela Dettori;Daniela Dettori;Rodrigo Leite de Oliveira;Rodrigo Leite de Oliveira;Sonja Loges;Sonja Loges

  916
  Citations

• Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family

  Kirsty S. Hewitson;Luke A. McNeill;Madeline V. Riordan;Ya-Min Tian

  899
  Citations

• HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

  Heidi M. Sowter;Peter J. Ratcliffe;Peter Watson;Arnold H. Greenberg

  874
  Citations