World's Best Scientists 2026 revealed!
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Biology and Biochemistry
UK
2026
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Biology and Biochemistry
Sweden
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
130
Citations
77361
World Ranking
397
National Ranking
23

Medicine

D-Index
128
Citations
76729
World Ranking
2664
National Ranking
278

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in Sweden Leader Award
  • 2023 - Research.com Medicine in Sweden Leader Award
  • 2022 - Research.com Biology and Biochemistry in Sweden Leader Award

Overview

Randall S. Johnson is affiliated with the University of Cambridge in the United Kingdom. Their research spans key areas in biochemistry, genetics, molecular biology, and medicine, with notable contributions to immunology, cancer research, molecular biology, physiology, and genetics.

Their work focuses on topics including cancer, hypoxia, and metabolism; immune cell function and interaction; immune cells in cancer; dementia and cognitive impairment research; adipose tissue and metabolism; epigenetics and DNA methylation; and CAR-T cell therapy research.

Johnson has contributed to several recent papers with significant academic impact. These include:

  • Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis (2020), published in Proceedings of the National Academy of Sciences
  • Cytotoxic T-cells mediate exercise-induced reductions in tumor growth (2020), published in eLife
  • A century of the Warburg effect (2023), published in Nature Metabolism
  • Oxygen regulation of TET enzymes (2021), published in FEBS Journal
  • Modified Hypoxia-Inducible Factor Expression in CD8+ T Cells Increases Antitumor Efficacy (2021), published in Cancer Immunology Research

Frequent collaborators of Johnson include:

  • Pedro P. Cunha
  • Helene Rundqvist
  • Pedro Veliça
  • Iosifina P. Foskolou
  • Laura Barbieri

The scientist regularly publishes in venues such as Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), eLife, Frontiers in Immunology, and Apollo (University of Cambridge).

Johnson's research contributions integrate cancer biology and metabolism with immune cell function, often exploring the metabolic states of immune cells in the tumor microenvironment and their implications for therapy. This multidisciplinary approach underlines their involvement in both fundamental and translational biomedical research.

Best Publications

  • RAG-1-deficient mice have no mature B and T lymphocytes

    Peter Mombaerts;John Iacomini;Randall Scott Johnson;Karl Herrup

  • HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation

    Thorsten Cramer;Yuji Yamanishi;Björn E Clausen;Irmgard Förster

  • HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

    Heather E. Ryan;Jessica Lo;Randall S. Johnson

  • HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

    Brian Keith;Randall S. Johnson;M. Celeste Simon;M. Celeste Simon

  • NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

    Jordi Rius;Monica Guma;Christian Schachtrup;Katerina Akassoglou

  • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

    Eiichi Araki;Eiichi Araki;Myra A. Lipes;Mary Elizabeth Patti;Jens Claus Brüning

  • Genetic mechanisms of critical illness in Covid-19.

    E. Pairo-Castineira;E. Pairo-Castineira;S. Clohisey;L. Klaric;A. D. Bretherick

  • HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

    Rose Du;Kan V. Lu;Claudia Petritsch;Patty Liu

  • The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

    Zhi-Wei Li;Wenming Chu;Yinling Hu;Mireille Delhase

  • HIF Transcription Factors, Inflammation, and Immunity

    Asis Palazon;Ananda W. Goldrath;Victor Nizet;Victor Nizet;Randall S. Johnson;Randall S. Johnson

  • Loss of PTEN facilitates HIF-1-mediated gene expression

    Wayne Zundel;Cornelia Schindler;Daphne Haas-Kogan;Albert Koong

  • Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

    Yinling Hu;Véronique Baud;Mireille Delhase;Peilin Zhang

  • Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

    Debra F. Higgins;Kuniko Kimura;Wanja M. Bernhardt;Nikita Shrimanker

  • Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth

    Heather E. Ryan;Michelle Poloni;Wayne McNulty;David Elson

  • Regulation of the HIF-1α level is essential for hematopoietic stem cells

    Keiyo Takubo;Nobuhito Goda;Wakako Yamada;Hirono Iriuchishima

  • Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.

    Gökhan S. Hotamisligil;Randall S. Johnson;Robert J. Distel;Ramsey Ellis

  • Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

    Ernestina Schipani;Heather E. Ryan;Susanna Didrickson;Tatsuya Kobayashi

  • Hypoxia: a key regulator of angiogenesis in cancer.

    Debbie Liao;Randall S. Johnson

  • Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

    Sarah R. Walmsley;Cristin G. Print;Neda Farahi;Carole Peyssonnaux

  • The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development

    Ying Wang;Chao Wan;Lianfu Deng;Ximeng Liu

Frequent Co-Authors

Victor Nizet
Victor Nizet University of California, San Diego
M. Celeste Simon
M. Celeste Simon University of Pennsylvania
Edwin R. Chilvers
Edwin R. Chilvers Imperial College London
Theodore M. DeJong
Theodore M. DeJong University of California, Davis
Ernestina Schipani
Ernestina Schipani University of Michigan–Ann Arbor
Virginia E. Papaioannou
Virginia E. Papaioannou Columbia University Medical Center
Bruce M. Spiegelman
Bruce M. Spiegelman Harvard University
Makoto Suematsu
Makoto Suematsu Keio University
Frank J. Giordano
Frank J. Giordano Yale University
Amato J. Giaccia
Amato J. Giaccia Stanford University

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