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Best Female Scientists
2025

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Best Female Scientists

D-Index
122
Citations
70977
World Ranking
487
National Ranking
286

Biology and Biochemistry

D-Index
127
Citations
76359
World Ranking
462
National Ranking
296

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2014 - Fellow of the American Academy of Arts and Sciences

Overview

M. Celeste Simon is affiliated with the University of Pennsylvania in the United States. Their research primarily intersects biochemistry, genetics, molecular biology, and medicine, with a substantial focus on fields such as molecular biology, cancer research, oncology, pulmonary and respiratory medicine, and genetics.

The main topics addressed in their work include:

  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Metabolism, Diabetes, and Cancer
  • Cancer Cells and Metastasis
  • Mitochondrial Function and Pathology
  • Immune cells in cancer

Among their most recent publications are the following papers:

  • "The tumor microenvironment," 2020, published in Current Biology
  • "Cellular adaptation to hypoxia through hypoxia inducible factors and beyond," 2020, published in Nature Reviews Molecular Cell Biology
  • "Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression," 2020, published in Cell
  • "Cancer Cells Don't Live Alone: Metabolic Communication within Tumor Microenvironments," 2020, published in Developmental Cell
  • "FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome," 2020, published in Nature Cell Biology

Frequent publishing venues for M. Celeste Simon include:

  • Cancer Research
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature Cell Biology

The scientist collaborates regularly with several co-authors, including:

  • Nicolas Skuli
  • Brian Keith
  • Laura C. Kim
  • Nathan J. Coffey
  • Fuming Li

Recognition for contributions to the field includes being named a Fellow of the American Academy of Arts and Sciences in 2014.

Best Publications

  • Hypoxia inducible factors and the response to hypoxic stress

    Amar J. Majmundar;Waihay J. Wong;M. Celeste Simon

  • Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

    Mary A. Selak;Sean M. Armour;Elaine D. MacKenzie;Houda Boulahbel

  • Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

    N. S. Chandel;E. Maltepe;E. Goldwasser;C. E. Mathieu

  • Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

    Joan E Durbin;Renée Hackenmiller;M.Celeste Simon;David E Levy

  • HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

    Brian Keith;Randall S. Johnson;M. Celeste Simon;M. Celeste Simon

  • Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals

    Maureen K. Bunger;Lisa D. Wilsbacher;Susan M. Moran;Cynthia Clendenin

  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

    Tullia Lindsten;Andrea J. Ross;Ayala King;Wei Xing Zong

  • Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

    Cheng-Jun Hu;Li-Yi Wang;Lewis A. Chodosh;Brian Keith

  • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

    Robert D. Guzy;Beatrice Hoyos;Emmanuel Robin;Hong Chen

  • The impact of O2 availability on human cancer.

    Jessica A. Bertout;Shetal A. Patel;M. Celeste Simon

  • The tumor microenvironment.

    Nicole M. Anderson;M. Celeste Simon

  • Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

    Larysa Pevny;M. Celeste Simon;Elizabeth Robertson;William H. Klein

  • Hypoxia-inducible factors, stem cells, and cancer.

    Brian Keith;M. Celeste Simon;M. Celeste Simon

  • Hypoxia-Induced Angiogenesis Good and Evil

    Bryan L. Krock;Nicolas Skuli;M. Celeste Simon

  • Stabilization of wild-type p53 by hypoxia-inducible factor 1α

    W G An;M Kanekal;M C Simon;E Maltepe

  • The role of oxygen availability in embryonic development and stem cell function.

    M. Celeste Simon;Brian Keith

  • Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development

    J. V. Schmidt;G. H.-T. Su;J. K. Reddy;M. C. Simon

  • Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

    David R. Wise;Patrick S. Ward;Jessica E. S. Shay;Justin R. Cross

  • HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth

    Kelly L. Covello;James Kehler;Hongwei Yu;John D. Gordan

  • Glutathione metabolism in cancer progression and treatment resistance.

    Ankita Bansal;M. Celeste Simon

Frequent Co-Authors

Brian Keith
Brian Keith University of Pennsylvania
Randall S. Johnson
Randall S. Johnson University of Cambridge
Itzhak Nissim
Itzhak Nissim Children's Hospital of Philadelphia
Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
J. Alan Diehl
J. Alan Diehl Case Western Reserve University
Katherine L. Nathanson
Katherine L. Nathanson University of Pennsylvania
Edward W. Scott
Edward W. Scott University of Florida
Anthony A. Mancuso
Anthony A. Mancuso University of Florida
W. Kimryn Rathmell
W. Kimryn Rathmell Vanderbilt University Medical Center
John M. Maris
John M. Maris Children's Hospital of Philadelphia

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