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D-Index & Metrics

Molecular Biology

D-Index
88
Citations
33430
World Ranking
778
National Ranking
412

Medicine

D-Index
90
Citations
35202
World Ranking
12086
National Ranking
6200

Overview

J. Alan Diehl is affiliated with Case Western Reserve University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions in Molecular Biology, Oncology, Immunology, Cell Biology, and Cancer Research.

The scientist's research topics cover a range of biological and medical themes including Cancer-related Molecular Pathways, Endoplasmic Reticulum Stress and Disease, Autophagy in Disease and Therapy, Ubiquitin and Proteasome Pathways, Cancer Cells and Metastasis, Cancer, Hypoxia, and Metabolism, as well as Immune Cell Function and Interaction.

Among recent publications, several noteworthy papers stand out:

  • A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression, 2022, Nature Cell Biology
  • The AMBRA1 E3 ligase adaptor regulates the stability of cyclin D, 2021, Nature
  • The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate, 2021, Biomedicines
  • Generation and Characterization of Patient-Derived Head and Neck, Oral, and Esophageal Cancer Organoids, 2020, Current Protocols in Stem Cell Biology
  • The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases, 2020, International Journal of Molecular Sciences

Diehl frequently collaborates with a number of co-authors, including:

  • Serge Y. Fuchs
  • Constantinos Koumenis
  • Andres J. Klein-Szanto
  • Hiroshi Nakagawa
  • Masataka Shimonosono

Their work is published repeatedly in several scientific venues, reflecting a continued presence in the research community. These venues include:

  • Cancer Research
  • International Journal of Molecular Sciences
  • Nature Cancer
  • Cell Metabolism
  • Molecular Cancer Research

Best Publications

  • Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

    J. Alan Diehl;Mangeng Cheng;Martine F. Roussel;Charles J. Sherr

  • The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.

    Mangeng Cheng;Paul Olivier;Paul Olivier;J.Alan Diehl;J.Alan Diehl;Matthew Fero;Matthew Fero

  • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.

    Sara B. Cullinan;Donna Zhang;Mark Hannink;Edward Arvisais

  • The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

    Sara B. Cullinan;John D. Gordan;Jianping Jin;J. Wade Harper

  • Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

    J A Diehl;F Zindy;C J Sherr

  • HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity

    John D. Gordan;Jessica A. Bertout;Cheng-Jun Hu;J. Alan Diehl

  • Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response.

    Yanjun Ma;Joseph W. Brewer;J. Alan Diehl;Linda M. Hendershot;Linda M. Hendershot

  • PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress

    Sara B. Cullinan;J. Alan Diehl

  • The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

    Jiangbin Ye;Monika Kumanova;Lori S Hart;Kelly Sloane

  • Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway.

    Sara B. Cullinan;J. Alan Diehl

  • Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

    Jodi R. Alt;John L. Cleveland;Mark Hannink;J. Alan Diehl

  • Cycling to Cancer with Cyclin D1

    J Alan Diehl

  • Cyclin D1, cancer progression, and opportunities in cancer treatment.

    Shuo Qie;J Alan Diehl

  • PERK mediates cell-cycle exit during the mammalian unfolded protein response

    Joseph W. Brewer;J. Alan Diehl

  • Nuclear cyclin D1: an oncogenic driver in human cancer.

    Jong Kyong Kim;J. Alan Diehl

  • Cyclin D1: polymorphism, aberrant splicing and cancer risk

    K E Knudsen;J Alan Diehl;C A Haiman;E S Knudsen

  • Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

    Douglas I. Lin;Olena Barbash;K.G. Suresh Kumar;Jason D. Weber

  • ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

    Lori S. Hart;John T. Cunningham;Tatini Datta;Souvik Dey

  • Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

    Joseph W. Brewer;Linda M. Hendershot;Charles J. Sherr;J. Alan Diehl

  • PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

    E Bobrovnikova-Marjon;C Grigoriadou;D Pytel;F Zhang

Frequent Co-Authors

Anil K. Rustgi
Anil K. Rustgi Columbia University
Andres J. P. Klein-Szanto
Andres J. P. Klein-Szanto Fox Chase Cancer Center
Serge Y. Fuchs
Serge Y. Fuchs University of Pennsylvania
Meenhard Herlyn
Meenhard Herlyn The Wistar Institute
Constantinos Koumenis
Constantinos Koumenis University of Pennsylvania
Kwok-Kin Wong
Kwok-Kin Wong New York University
M. Celeste Simon
M. Celeste Simon University of Pennsylvania
Phyllis A. Gimotty
Phyllis A. Gimotty University of Pennsylvania
Karen E. Knudsen
Karen E. Knudsen Thomas Jefferson University
Shoji Natsugoe
Shoji Natsugoe Kagoshima University

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