World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
26631
World Ranking
4962
National Ranking
2384

Overview

Linda M. Hendershot is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions spanning several subfields including cell biology, molecular biology, immunology, epidemiology, and surgery.

The scientist's work addresses various main topics, most notably endoplasmic reticulum stress and disease. Other topics of research covered in their publications include heat shock proteins research, RNA regulation and disease, toxin mechanisms and immunotoxins, autophagy in disease and therapy, coenzyme Q10 studies and effects, and pancreatic function and diabetes.

Linda M. Hendershot has published multiple papers in reputable venues. Recent notable publications include:

  • "Reshaping endoplasmic reticulum quality control through the unfolded protein response", 2022, Molecular Cell
  • "The Essential Functions of Molecular Chaperones and Folding Enzymes in Maintaining Endoplasmic Reticulum Homeostasis", 2023, Journal of Molecular Biology
  • "Role of the HSP70 Co-Chaperone SIL1 in Health and Disease", 2021, International Journal of Molecular Sciences
  • "The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice", 2022, JCI Insight
  • "Mapping SP-C co-chaperone binding sites reveals molecular consequences of disease-causing mutations on protein maturation", 2022, Nature Communications

Their frequent coauthors include Jeffrey L. Brodsky, Teresa M. Buck, Melissa J. Mann, Ashley R. Flory, and Aidan W. Porter. This collaborative network reflects a strong connection to expert groups working on molecular chaperones and protein folding.

Common publication venues for their work include the Journal of Molecular Biology, bioRxiv (Cold Spring Harbor Laboratory), Frontiers in Cell and Developmental Biology, Molecular Cell, and the International Journal of Molecular Sciences. The scientist has multiple papers published in these journals, reflecting an ongoing research presence in these forums.

Beyond articles, Linda M. Hendershot has also contributed to book publications, including a title published by Frontiers Media in 2023 titled "Protein Homeostasis in Growth, Development and Disease."

Best Publications

  • Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

    Anne Bertolotti;Yuhong Zhang;Linda M. Hendershot;Linda M. Hendershot;Heather P. Harding

  • ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals.

    Jingshi Shen;Xi Chen;Linda Hendershot;Linda Hendershot;Ron Prywes

  • Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

    D G Bole;L M Hendershot;J F Kearney

  • The role of the unfolded protein response in tumour development: friend or foe?

    Yanjun Ma;Linda M. Hendershot

  • Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response.

    Yanjun Ma;Joseph W. Brewer;J. Alan Diehl;Linda M. Hendershot;Linda M. Hendershot

  • Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

    Xiao Zhong Wang;Beth Lawson;Joseph W. Brewer;Hélène Zinszner

  • A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

    Laurent Meunier;Young Kwang Usherwood;Kyung Tae Chung;Linda M. Hendershot

  • BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation

    Brian D Hamman;Linda M Hendershot;Arthur E Johnson

  • The ER function BiP is a master regulator of ER function.

    Linda M Hendershot

  • ER chaperone functions during normal and stress conditions.

    Yanjun Ma;Linda M. Hendershot;Linda M. Hendershot

  • The unfolding tale of the unfolded protein response

    Yanjun Ma;Linda M. Hendershot;Linda M. Hendershot

  • Delineation of a Negative Feedback Regulatory Loop That Controls Protein Translation during Endoplasmic Reticulum Stress

    Yanjun Ma;Linda M. Hendershot;Linda M. Hendershot

  • Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein.

    L Hendershot;D Bole;G Köhler;J F Kearney

  • Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins.

    Jill A. Morris;Andrew J. Dorner;Chris A. Edwards;Linda M. Hendershot

  • The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends

    Kristine Faye R. Pobre;Greg J. Poet;Linda M. Hendershot

  • Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression

    Joseph W. Brewer;Linda M. Hendershot;Charles J. Sherr;J. Alan Diehl

  • BiP, a major chaperone protein of the endoplasmic reticulum lumen, plays a direct and important role in the storage of the rapidly exchanging pool of Ca2+

    Jean Philippe Lièvremont;Rosario Rizzuto;Linda Hendershot;Jacopo Meldolesi

  • GM1-ganglioside-mediated activation of the unfolded protein response causes neuronal death in a neurodegenerative gangliosidosis.

    Alessandra Tessitore;Maria del P. Martin;Renata Sano;Yanjun Ma

  • Mutations in SIL1 cause Marinesco-Sjogren syndrome, a cerebellar ataxia with cataract and myopathy

    J. Senderek;M. Krieger;C. Stendel;C. Bergmann

  • Dynamic interaction of BiP and ER stress transducers in the unfolded

    Anne Bertolotti;Yuhong Zhang;Linda M. Hendershot;David Ron

Frequent Co-Authors

David Ron
David Ron University of Cambridge
Johannes Buchner
Johannes Buchner Technical University of Munich
Heather P. Harding
Heather P. Harding University of Cambridge
Junmin Peng
Junmin Peng St. Jude Children's Research Hospital
John F. Kearney
John F. Kearney University of Alabama at Birmingham
Jeffrey L. Brodsky
Jeffrey L. Brodsky University of Pittsburgh
Mondira Kundu
Mondira Kundu St. Jude Children's Research Hospital
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Randal J. Kaufman
Randal J. Kaufman Sanford Burnham Prebys Medical Discovery Institute
Amy S. Lee
Amy S. Lee University of Southern California

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