2020 - Member of the Royal Irish Academy
Afshin Samali focuses on Cell biology, Apoptosis, Unfolded protein response, Endoplasmic reticulum and Programmed cell death. His study connects Cell and Cell biology. His Apoptosis study combines topics in areas such as Heat shock protein, Molecular biology, Cancer research and Cytosol.
His studies in Unfolded protein response integrate themes in fields like Transcription factor and Cellular homeostasis. His Endoplasmic reticulum research is multidisciplinary, incorporating elements of Neurodegeneration and EIF-2 kinase. His Programmed cell death research incorporates elements of Autophagy, BECN1, Autophagosome, Necrosis and Computational biology.
Afshin Samali mainly investigates Cell biology, Apoptosis, Unfolded protein response, Programmed cell death and Endoplasmic reticulum. Afshin Samali has researched Cell biology in several fields, including Heat shock protein, Cell and Tumor necrosis factor alpha. His Apoptosis study incorporates themes from Necrosis, Receptor, Cancer research and Immunology.
His work on ATF6 is typically connected to XBP1 as part of general Unfolded protein response study, connecting several disciplines of science. His Autophagy research extends to Programmed cell death, which is thematically connected. His work carried out in the field of Endoplasmic reticulum brings together such families of science as Secretory protein, Downregulation and upregulation, EIF-2 kinase and Cellular homeostasis.
His scientific interests lie mostly in Unfolded protein response, Cancer research, Endoplasmic reticulum, Cell biology and Programmed cell death. The ATF6 research he does as part of his general Unfolded protein response study is frequently linked to other disciplines of science, such as XBP1, therefore creating a link between diverse domains of science. His Cancer research research incorporates themes from Cancer cell, Cell, Cell culture and Apoptosis.
His study in the field of STIM1 also crosses realms of Membrane contact site. His Cell biology research incorporates themes from Inflammasome, Downregulation and upregulation and Cellular homeostasis. His research integrates issues of Autophagy, HEK 293 cells, Chemotherapy and Heat shock protein in his study of Programmed cell death.
Afshin Samali spends much of his time researching Unfolded protein response, Endoplasmic reticulum, Cancer research, Programmed cell death and Cell biology. His ATF6 study in the realm of Unfolded protein response connects with subjects such as XBP1. His study on STIM1 is often connected to Membrane contact site as part of broader study in Endoplasmic reticulum.
His work is dedicated to discovering how Cancer research, Cancer are connected with Gene expression and Transcriptome and other disciplines. His Programmed cell death research is multidisciplinary, relying on both Autophagy, HEK 293 cells, Paclitaxel and Temozolomide. Cell biology is often connected to Cellular homeostasis in his work.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin.
Mediators of endoplasmic reticulum stress-induced apoptosis.
Eva Szegezdi;Susan E Logue;Adrienne M Gorman;Afshin Samali.
EMBO Reports (2006)
Triggering and modulation of apoptosis by oxidative stress.
Joya Chandra;Afshin Samali;Sten Orrenius.
Free Radical Biology and Medicine (2000)
The integrated stress response.
Karolina Pakos‐Zebrucka;Izabela Koryga;Katarzyna Mnich;Mila Ljujic.
EMBO Reports (2016)
Cellular Stress Responses: Cell Survival and Cell Death
Simone Fulda;Adrienne M. Gorman;Osamu Hori;Afshin Samali.
International Journal of Cell Biology (2010)
The eIF2α kinases: their structures and functions
Neysan Donnelly;Adrienne M. Gorman;Sanjeev Gupta;Afshin Samali.
Cellular and Molecular Life Sciences (2013)
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
Afshin Samali;Jiyang Cai;Boris Zhivotovsky;Dean P. Jones.
The EMBO Journal (1999)
Heat Shock Proteins Increase Resistance to Apoptosis
Afshin Samali;Thomas G. Cotter.
Experimental Cell Research (1996)
On the role of Hsp27 in regulating apoptosis.
C. G. Concannon;A. M. Gorman;A. Samali.
Caspase-12 and ER-stress-mediated apoptosis: the story so far.
Eva Szegezdi;Una Fitzgerald;Afshin Samali.
Annals of the New York Academy of Sciences (2003)
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