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Medicine

D-Index
96
Citations
28353
World Ranking
9806
National Ranking
5041

Overview

Timothy O'Brien is affiliated with the University of Minnesota in the United States and conducts research primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work covers several specialized subfields including Genetics, Molecular Biology, Surgery, Endocrinology, Diabetes and Metabolism, and Cardiology and Cardiovascular Medicine.

Their research focuses on topics such as Mesenchymal stem cell research, Tissue Engineering and Regenerative Medicine, Pluripotent Stem Cells Research, CRISPR and Genetic Engineering, Diabetic Foot Ulcer Assessment and Management, Cancer Cells and Metastasis, and Neuroscience and Neural Engineering.

Recent publications authored or coauthored by Timothy O'Brien include:

  • The impact of chronic kidney disease on developed countries from a health economics perspective: A systematic scoping review, 2020, PLoS ONE
  • Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial, 2021, The Lancet Diabetes & Endocrinology
  • Safety and Preliminary Efficacy of Mesenchymal Stromal Cell (ORBCEL-M) Therapy in Diabetic Kidney Disease: A Randomized Clinical Trial (NEPHSTROM), 2023, Journal of the American Society of Nephrology
  • Targeting stromal cell Syndecan-2 reduces breast tumour growth, metastasis and limits immune evasion, 2020, International Journal of Cancer
  • Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose, 2020, Proceedings of the National Academy of Sciences

They frequently collaborate with a number of researchers with notable co-authors including Sanbing Shen, Veronica McInerney, Janusz Krawczyk, Clara Sanz-Nogués, and Stephen J. Elliman. These collaborations have contributed to a substantial body of work disseminated through various respected publication venues.

Timothy O'Brien has contributed extensively to journals such as College Athletics and the Law, Stem Cell Research, Cytotherapy, Stem Cell Research & Therapy, and Research Square, with the highest number of publications appearing in College Athletics and the Law and Stem Cell Research.

Best Publications

  • Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells.

    Per Westermark;Christer Wernstedt;Erik Wilander;David W. Hayden

  • Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells.

    R.M. Dwyer;S.M. Potter-Beirne;K.A. Harrington;A.J. Lowery

  • Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)

    F. T. Martin;Róisín M. Dwyer;J. Kelly;S. Khan

  • Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.

    P. Westermark;C. Wernstedt;T. D. O'Brien;D. W. Hayden

  • Immunogenicity of allogeneic mesenchymal stem cells.

    Sabine Schu;Mikhail Nosov;Lisa O'Flynn;Georgina Shaw

  • Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat

    Gerard F Curley;Mairead Hayes;Bilal Ansari;Georgina Shaw

  • Islet amyloid, islet-amyloid polypeptide, and diabetes mellitus

    Kenneth H. Johnson;Timothy D. O'Brien;Christer Betsholtz;Per Westermark

  • Effects of Immunosuppressants on Receptor Activator of NF-κB Ligand and Osteoprotegerin Production by Human Osteoblastic and Coronary Artery Smooth Muscle Cells

    Lorenz C. Hofbauer;Chaoxiang Shui;B.Lawrence Riggs;Colin R. Dunstan

  • Hyperlipidemia in Patients With Primary and Secondary Hypothyroidism

    Timothy O'brien;Sean F. Dinneen;Peter C. O'brien;Pasquale J. Palumbo

  • Immunolocalization of islet amyloid polypeptide (IAPP) in pancreatic beta cells by means of peroxidase-antiperoxidase (PAP) and protein A-gold techniques.

    K. H. Johnson;Timothy D O'Brien;D. W. Hayden;K. Jordan

  • Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds.

    Nicolas N. Madigan;Siobhan McMahon;Timothy O’Brien;Michael J. Yaszemski

  • ER stress contributes to ischemia-induced cardiomyocyte apoptosis.

    Eva Szegezdi;Angela Duffy;Martin E. O’Mahoney;Susan E. Logue

  • Evidence for Proteotoxicity in β Cells in Type 2 Diabetes: Toxic Islet Amyloid Polypeptide Oligomers Form Intracellularly in the Secretory Pathway

    Tatyana Gurlo;Sergey Ryazantsev;Chang Jiang Huang;Michael W. Yeh

  • Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors

    J M McMahon;S Conroy;M Lyons;U Greiser

  • Hyperlipidemia and diabetes mellitus.

    Timothy O'Brien;Tu T. Nguyen;Bruce R. Zimmerman

  • Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment.

    Louise A. Mylotte;Angela M. Duffy;Mary Murphy;Timothy O'Brien;Timothy O'Brien

  • Differential miRNA Expression in Omental Adipose Tissue and in the Circulation of Obese Patients Identifies Novel Metabolic Biomarkers

    H. M. Heneghan;N. Miller;O. J. McAnena;T. O'Brien

  • Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

    James Devaney;Shahd Horie;Claire Masterson;Steve Elliman

  • Prospective Evaluation of Roux-en-Y Gastric Bypass as Primary Operation for Medically Complicated Obesity

    Bruno M. Balsiger;Frank P. Kennedy;Haitham S. Abu-Lebdeh;Maria Collazo-Clavell

  • Adipocyte macrophage colony-stimulating factor is a mediator of adipose tissue growth.

    James A. Levine;Michael D. Jensen;Norman L. Eberhardt;Timothy O'Brien

Frequent Co-Authors

Abhay Pandit
Abhay Pandit University of Galway
Per Westermark
Per Westermark Uppsala University
Jaime F. Modiano
Jaime F. Modiano University of Minnesota
Michael J. Kerin
Michael J. Kerin University of Galway
Peter Gloviczki
Peter Gloviczki Mayo Clinic
John G. Laffey
John G. Laffey University of Galway
Afshin Samali
Afshin Samali University of Galway

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