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D-Index & Metrics

Medicine

D-Index
83
Citations
31291
World Ranking
15447
National Ranking
7790

Overview

Peter C. Butler is affiliated with the University of California, Los Angeles in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Key subfields include Surgery, Genetics, Molecular Biology, Endocrinology, Diabetes and Metabolism, and Physiology.

The scientist's work concentrates on topics related to pancreatic function and diabetes, as well as metabolism and associated disorders. Specific areas of interest include:

  • Pancreatic function and diabetes
  • Diabetes and associated disorders
  • Metabolism, Diabetes, and Cancer
  • Endoplasmic Reticulum Stress and Disease
  • Diabetes Management and Research
  • Diet, Metabolism, and Disease
  • Erythrocyte Function and Pathophysiology

They have contributed publications in several notable scientific venues, with multiple papers appearing in journals such as:

  • Diabetes
  • Communications Biology
  • Science Advances
  • Diabetologia
  • Metabolism

Recent papers showcase a focus on cellular and molecular mechanisms involved in diabetes, including:

  • Live-cell imaging of glucose-induced metabolic coupling of β and α cell metabolism in health and type 2 diabetes, 2021, Communications Biology
  • Visualizing insulin vesicle neighborhoods in β cells by cryo-electron tomography, 2020, Science Advances
  • IAPP-induced beta cell stress recapitulates the islet transcriptome in type 2 diabetes, 2021, Diabetologia
  • The β-cell glucose toxicity hypothesis: Attractive but difficult to prove, 2021, Metabolism
  • A transparent low intensity pulsed ultrasound (LIPUS) chip for high-throughput cell stimulation, 2021, Lab on a Chip

Frequent collaborators include researchers such as Tatyana Gurlo, Zhongying Wang, Madeline Rosenberger, Scott E. Fraser, and Montgomery Blencowe, indicating ongoing partnerships in their research projects.

Best Publications

  • β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

    Alexandra E. Butler;Juliette Janson;Susan Bonner-Weir;Robert A Ritzel

  • Increased Risk of Type 2 Diabetes in Alzheimer Disease

    Juliette Janson;Thomas Laedtke;Joseph E. Parisi;Peter O’Brien

  • Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies

    Michael Elashoff;Aleksey V. Matveyenko;Belinda Gier;Robert Elashoff

  • Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

    Rakez Kayed;Elizabeth Head;Floyd Sarsoza;Tommy Saing

  • β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans

    Juris J. Meier;Alexandra E. Butler;Yoshifumi Saisho;Travis Monchamp

  • The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

    Juliette Janson;Richard H. Ashley;David Harrison;Susan McIntyre

  • Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

    Leena Haataja;Tatyana Gurlo;Chang J. Huang;Peter C. Butler

  • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

    J. J. Meier;A. Bhushan;A. E. Butler;R. A. Rizza

  • Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid.

    Alexandra E. Butler;Juliette Janson;Walter C. Soeller;Peter C. Butler

  • Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors

    Alexandra E. Butler;Martha Campbell-Thompson;Tatyana Gurlo;David W. Dawson

  • High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes

    Chang Jiang Huang;Chia Yu Lin;Leena Haataja;Tatyana Gurlo

  • Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes

    Y. Saisho;A. E. Butler;J. J. Meier;T. Monchamp

  • Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

    A. E. Butler;L. Cao-Minh;R. Galasso;R. A. Rizza

  • Effects of Meal Ingestion on Plasma Amylin Concentration in NIDDM and Nondiabetic Humans

    P. C. Butler;J. Chou;W. B. Carter;Yeng-Nung Wang

  • Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

    Juliette Janson;Walter C. Soeller;Patrick C. Roche;Robin T. Nelson

  • β-Cell Mass and Turnover in Humans: Effects of obesity and aging

    Yoshifumi Saisho;Alexandra E. Butler;Erica Manesso;David Elashoff

  • Assessment of β-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous and oral glucose tests

    Claudio Cobelli;Gianna Maria Toffolo;Chiara Dalla Man;Marco Campioni

  • Type 2 diabetes as a protein misfolding disease

    Abhisek Mukherjee;Diego Morales-Scheihing;Peter C. Butler;Claudio Soto

  • The replication of beta cells in normal physiology, in disease and for therapy.

    Peter C Butler;Juris J Meier;Alexandra E Butler;Anil Bhushan

  • A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Are the GLP-1 therapies safe?

    Peter C. Butler;Michael Elashoff;Robert Elashoff;Edwin A.M. Gale

Frequent Co-Authors

Robert A. Rizza
Robert A. Rizza Mayo Clinic
Juris J. Meier
Juris J. Meier Ruhr University Bochum
Claudio Cobelli
Claudio Cobelli University of Padua
Timothy O'Brien
Timothy O'Brien University of Minnesota
Ralf Langen
Ralf Langen University of Southern California
Charles G. Glabe
Charles G. Glabe University of California, Irvine
Antoinette Moran
Antoinette Moran University of Minnesota
Ole Schmitz
Ole Schmitz Aarhus University Hospital
Rakez Kayed
Rakez Kayed The University of Texas Medical Branch at Galveston

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