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Biology and Biochemistry

D-Index
68
Citations
15700
World Ranking
7832
National Ranking
3561

Overview

Ralf Langen is affiliated with the University of Southern California in the United States. Their research primarily focuses on biochemical and molecular biology aspects related to neurodegenerative diseases and cellular processes. Their body of work spans across various subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Physiology, and Cell Biology.

Their scientific contributions cover a broad range of topics, with a particular emphasis on:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • RNA Research and Splicing
  • Neurological disorders and treatments
  • Fungal and yeast genetics research
  • Alzheimer's disease research and treatments
  • Nuclear Structure and Function

Langen has co-authored numerous papers with frequent collaborators including J. Mario Isas, Jeannie Chen, Jobin Varkey, Nitin Pandey, and Hui Xu.

Their recent publications demonstrate a focus on protein aggregation, membrane interactions, and neurodegenerative pathologies. Selected recent papers include:

  • "Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted," 2021, Nature Communications
  • "Lysine acetylation regulates the interaction between proteins and membranes," 2021, Nature Communications
  • "Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1," 2023, Journal of Biological Chemistry
  • "Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells," 2020, ACS Chemical Neuroscience
  • "An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles," 2020, Viruses

The frequent venues for their publications include the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Neurobiology of Disease, and Biophysical Journal. Their work in these journals underscores their engagement with biochemical research and neuroscience.

Langen's publication record also reflects an involvement in medicine, with studies intersecting molecular and neurological diseases, particularly focusing on mechanisms relevant for neurodegeneration and cellular pathology.

Best Publications

  • Recent advances in site-directed spin labeling of proteins

    Wayne L Hubbell;Adrian Gross;Ralf Langen;Michael A Lietzow

  • Mechanism of endophilin N-BAR domain-mediated membrane curvature.

    Jennifer L Gallop;Christine C Jao;Helen M Kent;P Jonathan G Butler

  • Structure of membrane-bound α-synuclein from site-directed spin labeling and computational refinement

    Christine C. Jao;Balachandra G. Hegde;Jeannie Chen;Ian S. Haworth

  • Electron Tunneling in Proteins: Coupling Through a β Strand

    Ralf Langen;I-Jy Chang;Juris P. Germanas;John H. Richards

  • Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling

    Marianna Török;Saskia Milton;Rakez Kayed;Peng Wu

  • Structure of membrane-bound α-synuclein studied by site-directed spin labeling

    Christine C. Jao;Ani Der-Sarkissian;Jeannie Chen;Ralf Langen

  • Structural Organization of α-Synuclein Fibrils Studied by Site-directed Spin Labeling

    Ani Der-Sarkissian;Christine C. Jao;Jeannie Chen;Ralf Langen

  • Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

    Jobin Varkey;Jose Mario Isas;Naoko Mizuno;Martin Borch Jensen

  • Lipid membranes modulate the structure of islet amyloid polypeptide.

    Sajith A Jayasinghe;Ralf Langen

  • Structure and Analysis of Fcho2 F-Bar Domain: A Dimerizing and Membrane Recruitment Module that Effects Membrane Curvature.

    William Mike Henne;Helen M. Kent;Marijn G.J. Ford;Balachandra G. Hegde

  • Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.

    Axel Montagne;Angeliki M Nikolakopoulou;Zhen Zhao;Abhay P Sagare

  • Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure.

    Ralf Langen;Kyoung Joon Oh;Duilio Cascio;Wayne L. Hubbell

  • Template-assisted filament growth by parallel stacking of tau

    Martin Margittai;Ralf Langen

  • Investigation of α-Synuclein Fibril Structure by Site-directed Spin Labeling

    Min Chen;Martin Margittai;Jeannie Chen;Ralf Langen

  • Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers

    Volker Luibl;Jose M. Isas;Rakez Kayed;Charles G. Glabe

  • O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

    Nicholas P. Marotta;Yu Hsuan Lin;Yuka E. Lewis;Mark R. Ambroso

  • Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding *

    Melania Apostolidou;Sajith A. Jayasinghe;Ralf Langen

  • Membrane interaction of islet amyloid polypeptide

    Sajith A. Jayasinghe;Ralf Langen

  • Protein Control of Iron-Sulfur Cluster Redox Potentials"

    R Langen;G M Jensen;U Jacob;P J Stephens

  • Inhibition of human IAPP fibril formation does not prevent β-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP

    Juris J. Meier;Rakez Kayed;Chia Yu Lin;Tatyana Gurlo

Frequent Co-Authors

Jay R. Winkler
Jay R. Winkler California Institute of Technology
Peter C. Butler
Peter C. Butler University of California, Los Angeles
Wayne L. Hubbell
Wayne L. Hubbell University of California, Los Angeles
Alasdair C. Steven
Alasdair C. Steven National Institutes of Health
Charles G. Glabe
Charles G. Glabe University of California, Irvine
Arieh Warshel
Arieh Warshel University of Southern California
Rakez Kayed
Rakez Kayed The University of Texas Medical Branch at Galveston
Harvey T. McMahon
Harvey T. McMahon MRC Laboratory of Molecular Biology
Naiqian Cheng
Naiqian Cheng National Institutes of Health
Harry B. Gray
Harry B. Gray California Institute of Technology

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