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Biology and Biochemistry

D-Index
87
Citations
43900
World Ranking
2770
National Ranking
202

Overview

Harvey T. McMahon is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with significant contributions also in medicine. The scientist's work is distributed across various subfields, including cell biology, molecular biology, infectious diseases, surgery, and immunology and allergy.

Their research topics reflect a focus on cellular processes and disease mechanisms. The main topics covered in their publications include:

  • Cellular transport and secretion
  • Cellular mechanics and interactions
  • Pancreatic function and diabetes
  • Cell adhesion molecules research
  • SARS-CoV-2 and COVID-19 research
  • CRISPR and genetic engineering
  • Endoplasmic reticulum stress and disease

Harvey T. McMahon has published extensively in prominent scientific journals. Frequent publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Cell Biology
  • Cell Reports
  • PLoS Pathogens
  • Nature Communications

Recent papers authored or co-authored by McMahon include the following:

  • "Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion," 2021, PLoS Pathogens
  • "Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508," 2020, The Journal of Cell Biology
  • "Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis," 2023, Nature Communications
  • "Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1," 2023, The Journal of Cell Biology

The scientist has collaborated frequently with several researchers, indicating ongoing partnerships in their field. Frequent co-authors include:

  • Leônardo Almeida-Souza
  • Yvonne Vallis
  • David Paul
  • Inês Cebola
  • Gaëlle Carrat

Harvey T. McMahon's research contributions address mechanisms of cellular transport and secretion, cell adhesion, and protein processing, with particularly notable work relating to viral entry mechanisms as observed in their studies on SARS-CoV-2 Spike protein cleavage.

Best Publications

  • Mechanisms of Endocytosis

    Gary J. Doherty;Harvey T. McMahon

  • Molecular mechanism and physiological functions of clathrin-mediated endocytosis

    Harvey T. McMahon;Emmanuel Boucrot

  • Membrane curvature and mechanisms of dynamic cell membrane remodelling

    Harvey T. McMahon;Jennifer L. Gallop

  • BAR domains as sensors of membrane curvature: the amphiphysin BAR structure

    Brian J. Peter;Helen M. Kent;Ian G. Mills;T. Yvonne Vallis

  • The dynamin superfamily: universal membrane tubulation and fission molecules?

    Gerrit J. K. Praefcke;Harvey T. McMahon

  • Curvature of clathrin-coated pits driven by epsin

    Marijn G. J. Ford;Ian G. Mills;Brian J. Peter;Yvonne Vallis

  • Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.

    Tetsuya Hayashi;Harvey McMahon;Shinji Yamasaki;Thomas Binz

  • Simultaneous Binding of Ptdins(4,5)P2 and Clathrin by Ap180 in the Nucleation of Clathrin Lattices on Membranes

    Marijn G. J. Ford;Barbara M. F. Pearse;Matthew K. Higgins;Yvonne Vallis

  • The structural era of endocytosis.

    M. Marsh;H. T. McMahon

  • Mechanisms of membrane fusion: disparate players and common principles

    Sascha Martens;Harvey T. McMahon

  • Membrane curvature at a glance

    Harvey T. McMahon;Emmanuel Boucrot

  • Complexins: Cytosolic proteins that regulate SNAP receptor function

    Harvey T. McMahon;Markus Missler;Cai Li;Thomas C. Südhof

  • Mechanism of endophilin N-BAR domain-mediated membrane curvature.

    Jennifer L Gallop;Christine C Jao;Helen M Kent;P Jonathan G Butler

  • How synaptotagmin promotes membrane fusion.

    Sascha Martens;Michael M. Kozlov;Harvey T. McMahon

  • Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein

    Harvey T. McMahon;Yuri A. Ushkaryov;Lambert Edelmann;Egenhard Link

  • Complexins regulate a late step in Ca2+-dependent neurotransmitter release.

    Kerstin Reim;Michael Mansour;Frederique Varoqueaux;Harvey T. McMahon

  • GTPase activity of dynamin and resulting conformation change are essential for endocytosis.

    Bruno Marks;Michael H. B. Stowell;Yvonne Vallis;Ian G. Mills

  • FCHo proteins are nucleators of clathrin-mediated endocytosis

    William Mike Henne;Emmanuel Boucrot;Michael Meinecke;Emma Evergren

  • Endophilin marks and controls a clathrin-independent endocytic pathway

    Emmanuel Boucrot;Antonio P. A. Ferreira;Leonardo Almeida-Souza;Sylvain Debard

  • Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides

    Jez Carlton;Miriam Bujny;Brian J. Peter;Viola M.J. Oorschot

Frequent Co-Authors

David G. Nicholls
David G. Nicholls Buck Institute for Research on Aging
Ian G. Mills
Ian G. Mills University of Oxford
Michael M. Kozlov
Michael M. Kozlov Tel Aviv University
Sascha Martens
Sascha Martens University of Vienna
Ludger Johannes
Ludger Johannes Institute Curie
Thomas C. Südhof
Thomas C. Südhof Stanford University
Patricia Bassereau
Patricia Bassereau Institute Curie
Robert G. Parton
Robert G. Parton University of Queensland
Ralf Langen
Ralf Langen University of Southern California
Gregory A. Voth
Gregory A. Voth University of Chicago

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