World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
42560
World Ranking
3611
National Ranking
1806

Overview

Rakez Kayed is affiliated with The University of Texas Medical Branch at Galveston in the United States. Their research primarily focuses on the intersection of medicine, biochemistry, genetics, molecular biology, and neuroscience, with a significant emphasis on neurodegenerative diseases and molecular mechanisms.

Their most recent published papers include:

  • "Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis" (2021, Chemical Reviews)
  • "Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons" (2020, Brain)
  • "Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases" (2022, Progress in Neurobiology)
  • "Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia" (2021, Cell Reports)
  • "P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease" (2020, Acta Neuropathologica Communications)

The scientist's frequent co-authors include:

  • Nemil Bhatt (35 collaborations)
  • Nicha Puangmalai (24 collaborations)
  • Mauro Montalbano (24 collaborations)
  • Urmi Sengupta (23 collaborations)
  • Cynthia Jerez (14 collaborations)

They have published extensively in several venues, with the top publication outlets being:

  • Alzheimer s & Dementia (26 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (15 publications)
  • Journal of Biological Chemistry (6 publications)
  • SSRN Electronic Journal (4 publications)
  • Progress in Neurobiology (3 publications)

Their main fields of study are:

  • Medicine (159 publications)
  • Biochemistry, Genetics and Molecular Biology (71 publications)
  • Neuroscience (62 publications)

Within these fields, Rakez Kayed explores several subfields, including:

  • Physiology (84 publications)
  • Neurology (61 publications)
  • Molecular Biology (60 publications)
  • Cellular and Molecular Neuroscience (23 publications)
  • Pharmacology (12 publications)

Their main topics of research work focus on:

  • Alzheimer's disease research and treatments (158 publications)
  • Neuroinflammation and Neurodegeneration Mechanisms (52 publications)
  • Neuroscience and Neuropharmacology Research (40 publications)
  • Parkinson's Disease Mechanisms and Treatments (32 publications)
  • Cholinesterase and Neurodegenerative Diseases (24 publications)
  • Prion Diseases and Protein Misfolding (16 publications)
  • RNA Research and Splicing (16 publications)

Best Publications

  • Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction

    Salvatore Oddo;Antonella Caccamo;Jason D. Shepherd;M. Paul Murphy

  • Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

    Rakez Kayed;Elizabeth Head;Jennifer L. Thompson;Theresa M. McIntire

  • A specific amyloid-|[beta]| protein assembly in the brain impairs memory

    Sylvain Lesné;Ming Teng Koh;Linda Kotilinek;Rakez Kayed

  • Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

    Fusheng Yang;Giselle P. Lim;Giselle P. Lim;Aynun N. Begum;Aynun N. Begum;Oliver J. Ubeda;Oliver J. Ubeda

  • NLRP3 inflammasome activation drives tau pathology

    Christina Ising;Carmen Venegas;Shuangshuang Zhang;Hannah Scheiblich

  • Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.

    Angelo Demuro;Erene Mina;Rakez Kayed;Saskia C. Milton

  • iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

    Edsel M. Abud;Ricardo N. Ramirez;Eric S. Martinez;Luke M. Healy

  • Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

    Rakez Kayed;Yuri Sokolov;Brian Edmonds;Theresa M. McIntire

  • Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

    Rakez Kayed;Elizabeth Head;Floyd Sarsoza;Tommy Saing

  • Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct

    Mihaela Necula;Rakez Kayed;Saskia Milton;Charles G. Glabe

  • The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

    Urmi Sengupta;Ashley N. Nilson;Rakez Kayed

  • Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

    Phuong H. Nguyen;Ayyalusamy Ramamoorthy;Bikash R. Sahoo;Jie Zheng

  • Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

    Cristian A Lasagna-Reeves;Diana L Castillo-Carranza;Urmi Sengupta;Audra L Clos

  • Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

    Jessica W. Wu;Mathieu Herman;Li Liu;Sabrina Simoes

  • Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.

    Cristian A. Lasagna-Reeves;Diana L. Castillo-Carranza;Urmi Sengupta;Marcos J. Guerrero-Munoz

  • Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

    Cristian A. Lasagna-Reeves;Diana L. Castillo-Carranza;Urmi Sengupta;Jose Sarmiento;Jose Sarmiento

  • Molecular mechanisms of amyloid oligomers toxicity.

    Rakez Kayed;Cristian A. Lasagna-Reeves

  • Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

    Charles G. Glabe;Rakez Kayed

  • Structural and Dynamic Features of Alzheimer's Aβ Peptide in Amyloid Fibrils Studied by Site-directed Spin Labeling

    Marianna Török;Saskia Milton;Rakez Kayed;Peng Wu

  • Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

    Jun Zhou;María I Fonseca;Rakez Kayed;Irma Arias Hernández

Frequent Co-Authors

Charles G. Glabe
Charles G. Glabe University of California, Irvine
Giulio Taglialatela
Giulio Taglialatela The University of Texas Medical Branch at Galveston
Kelly T. Dineley
Kelly T. Dineley The University of Texas Medical Branch at Galveston
Elizabeth Head
Elizabeth Head University of California, Irvine
Carl W. Cotman
Carl W. Cotman University of California, Irvine
Ralf Langen
Ralf Langen University of Southern California
Alan D.T. Barrett
Alan D.T. Barrett The University of Texas Medical Branch at Galveston
Huda Y. Zoghbi
Huda Y. Zoghbi Baylor College of Medicine
Tsuneya Ikezu
Tsuneya Ikezu Boston University
Howard E. Gendelman
Howard E. Gendelman University of Nebraska Medical Center

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