World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
58
Citations
11095
World Ranking
4194
National Ranking
361

Overview

Oliver Wirths is affiliated with the University of Göttingen in Germany and conducts research primarily in the fields of Medicine and Neuroscience. Their work spans several subfields including Physiology, Neurology, Molecular Biology, Psychiatry and Mental Health, and Oncology. The main topics addressed in their research include Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neurogenesis and neuroplasticity mechanisms, tryptophan and brain disorders, dementia and cognitive impairment research, cytokine signaling pathways and interactions, and computational drug discovery methods.

Wirths has published extensively with notable papers such as:

  • Neuron Loss in Alzheimer's Disease: Translation in Transgenic Mouse Models, 2020, International Journal of Molecular Sciences
  • Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease, 2023, Nature
  • A microRNA signature that correlates with cognition and is a target against cognitive decline, 2021, EMBO Molecular Medicine
  • Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice, 2024, Nature Neuroscience
  • Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis, 2024, Immunity

Frequent coauthors in Wirths's research collaborations include Jens Wiltfang, Hans-Wolfgang Klafki, Silvia Zampar, Thomas Meyer, and Olaf Jahn.

Publication venues where Wirths has contributed multiple works include:

  • Cell Communication and Signaling
  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunity
  • Cellular and Molecular Life Sciences

Wirths has authored books published by Exon Publications eBooks, including a work titled Alzheimer's Disease: Drug Discovery released in 2020.

Best Publications

  • Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

    Sadim Jawhar;Anna Trawicka;Carolin Jenneckens;Thomas A. Bayer

  • Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model

    Caty Casas;Nicolas Sergeant;Jean-Michel Itier;Véronique Blanchard

  • A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade.

    Oliver Wirths;Gerd Multhaup;Thomas A. Bayer

  • Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice

    Oliver Wirths;Gerd Multhaup;Christian Czech;Véronique Blanchard

  • Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

    Unknown

  • Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease.

    Christoph Schmitz;Christoph Schmitz;Christoph Schmitz;Bart P.F. Rutten;Bart P.F. Rutten;Bart P.F. Rutten;Andrea Pielen;Stephanie Schäfer;Stephanie Schäfer

  • Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice

    Véronique Blanchard;Saliha Moussaoui;Christian Czech;Nathalie Touchet

  • Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

    Thomas A Bayer;Oliver Wirths

  • Pyroglutamate Amyloid-β (Aβ): A Hatchet Man in Alzheimer Disease

    Sadim Jawhar;Oliver Wirths;Thomas A. Bayer

  • Key Factors in Alzheimer's Disease: β‐amyloid Precursor Protein Processing, Metabolism and Intraneuronal Transport

    Thomas A. Bayer;Oliver Wirths;Katalin Majtényi;Tobias Hartmann

  • Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.

    Oliver Wirths;Henning Breyhan;Holger Cynis;Stephan Schilling

  • N-truncated amyloid β (Aβ) 4-42 forms stable aggregates and induces acute and long-lasting behavioral deficits

    Yvonne Bouter;Katharina Dietrich;Jessica L. Wittnam;Nasrollah Rezaei-Ghaleh

  • Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia

    Melanie Hüttenrauch;Isabella Ogorek;Hans Klafki;Markus Otto

  • Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's disease.

    Thomas A. Bayer;Oliver Wirths

  • Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice

    Oliver Wirths;Gerd Multhaup;Christian Czech;Nicole Feldmann

  • Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

    Ditte Zerlang Christensen;Sophie Luise Kraus;Antonius Flohr;Marie-Caroline Cotel

  • Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer’s disease

    Oliver Wirths;Joachim Weis;Jacek Szczygielski;Gerd Multhaup

  • Age-dependent axonal degeneration in an Alzheimer mouse model.

    Oliver Wirths;Joachim Weis;Rakez Kayed;Takaomi C. Saido

  • Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.

    Vivek Venkataramani;Christian Rossner;Lara Iffland;Stefan Schweyer

  • Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease.

    Oliver Wirths;Henning Breyhan;Andrea Marcello;Marie-Caroline Cotel

  • Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease A NOVEL TOOL FOR THERAPY AND DIAGNOSIS

    Oliver Wirths;Christian Erck;Henrik Martens;Anja Harmeier

Frequent Co-Authors

Christoph Schmitz
Christoph Schmitz Maastricht University
Bart P. F. Rutten
Bart P. F. Rutten Maastricht University Medical Centre
Harry W.M. Steinbusch
Harry W.M. Steinbusch Maastricht University
Wolfgang Härtig
Wolfgang Härtig Leipzig University
Erik Portelius
Erik Portelius Sahlgrenska University Hospital
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg
Kaj Blennow
Kaj Blennow University of Gothenburg
David Liebetanz
David Liebetanz University of Göttingen
Marcella Rietschel
Marcella Rietschel Heidelberg University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring neuroscience in the USA opens up a wide array of academic and professional opportunities. For students looking to fast-track their education, pursuing an accelerated bachelor's degree online is an efficient way to gain credentials and enter the workforce more quickly. These programs are designed to be flexible and can be a great fit for learners balancing other commitments.

Career prospects are a key consideration for neuroscience students. Many fields related to neuroscience are among the highest earning degrees and can lead to some of the best degrees to make money. Whether your interests lie in research, healthcare, or biotechnology, a strong academic foundation can translate into lucrative career paths.

For those concerned about cost, there are numerous online college courses with financial aid options available. Financial aid, scholarships, and affordable tuition can make a neuroscience degree more accessible, ensuring that students can focus on building their future without overwhelming financial stress.

Best Scientists Citing Oliver Wirths

Trending Scientists