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Matthias Staufenbiel

Matthias Staufenbiel

D-Index & Metrics

Neuroscience

D-Index
107
Citations
41863
World Ranking
613
National Ranking
41

Medicine

D-Index
107
Citations
41964
World Ranking
6259
National Ranking
356

Overview

Matthias Staufenbiel is affiliated with the University of Tübingen in Germany. Their research spans medicine and biochemistry, genetics and molecular biology, with a particular focus on physiology and molecular biology as primary subfields. Staufenbiel's work addresses topics such as Alzheimer's disease research and treatments, cell death mechanisms and regulation, prion diseases and protein misfolding, trace elements in health, cholinesterase and neurodegenerative diseases, RNA regulation and disease, and neuroinflammation and neurodegeneration mechanisms.

The scientist has contributed to a number of articles published in well-known journals. Notable recent papers include:

  • Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life (2020, Nature Neuroscience)
  • Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae (2022, Nature Communications)
  • Signatures of glial activity can be detected in the CSF proteome (2022, Proceedings of the National Academy of Sciences)
  • Inhibition of an Alzheimer's disease-associated form of necroptosis rescues neuronal death in mouse models (2024, Science Translational Medicine)
  • Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360 (2021, Journal of Medicinal Chemistry)

Their frequent coauthors include Marta J. Koper, Simona Ospitalieri, Sabine Rabe, Bart De Strooper, and Sriram Balusu, each having collaborated on at least four publications. Staufenbiel's research has appeared in multiple publications in venues including Alzheimer's & Dementia (3 publications), Nature Neuroscience, Nature Communications, Proceedings of the National Academy of Sciences, and Science Translational Medicine, reflecting a sustained engagement with leading journals in neurodegenerative disease and neurological research.

Research topics frequently addressed are:

  • Alzheimer's disease research and treatments
  • Cell death mechanisms and regulation
  • Prion Diseases and Protein Misfolding
  • Trace Elements in Health
  • Cholinesterase and Neurodegenerative Diseases
  • RNA regulation and disease
  • Neuroinflammation and Neurodegeneration Mechanisms

Best Publications

  • Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

    Lars M. Ittner;Yazi D. Ke;Fabien Delerue;Mian Bi

  • Transmission and spreading of tauopathy in transgenic mouse brain

    Florence Clavaguera;Tristan Bolmont;R. Anthony Crowther;Dorothee Abramowski

  • Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

    Christine Sturchler-Pierrat;Dorothee Abramowski;Mairead Duke;Karl-Heinz Wiederhold

  • Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

    Marc Aurel Busche;Gerhard Eichhoff;Gerhard Eichhoff;Helmuth Adelsberger;Helmuth Adelsberger;Dorothee Abramowski

  • Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

    Melanie Meyer-Luehmann;Janaky Coomaraswamy;Tristan Bolmont;Tristan Bolmont;Stephan Kaeser

  • Innate immune memory in the brain shapes neurological disease hallmarks

    Ann-Christin Wendeln;Ann-Christin Wendeln;Karoline Degenhardt;Karoline Degenhardt;Lalit Kaurani;Lalit Kaurani;Michael Gertig;Michael Gertig

  • Brain homogenates from human tauopathies induce tau inclusions in mouse brain.

    Florence Clavaguera;Hiroyasu Akatsu;Graham Fraser;R. Anthony Crowther

  • Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

    M. Pfeifer;S. Boncristiano;L. Bondolfi;A. Stalder

  • Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease

    Marc Aurel Busche;Xiaowei Chen;Horst A. Henning;Julia Reichwald

  • Destabilization of beta catenin by mutations in presenilin-1 potentiates neuronal apoptosis

    Zhuohua Zhang;H. Hartmann;Viet Minh Do;D. Abramowski

  • Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

    Xiulian Sun;Guiqiong He;Guiqiong He;Hong Qing;Weihui Zhou

  • Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis

    Yvonne S. Eisele;Ulrike Obermüller;Ulrike Obermüller;Götz Heilbronner;Götz Heilbronner;Frank Baumann;Frank Baumann

  • Neuron loss in APP transgenic mice

    Michael E. Calhoun;Karl-Heinz Wiederhold;Dorothee Abramowski;Amie L. Phinney

  • Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia

    Stefan Grathwohl;R.E. Kälin;T. Bolmont;S. Prokop

  • Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

    Martin C Herzig;David T Winkler;Patrick Burgermeister;Michelle Pfeifer;Michelle Pfeifer

  • Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

    Michael E. Calhoun;Patrick Burgermeister;Amie L. Phinney;Martina Stalder

  • Brain estrogen deficiency accelerates Aβ plaque formation in an Alzheimer's disease animal model

    Xu Yue;Melissa Lu;Techie Lancaster;Phillip Cao

  • Association of microglia with amyloid plaques in brains of APP23 transgenic mice.

    Martina Stalder;Amie Phinney;Alphonse Probst;Bernd Sommer

  • Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer's mice

    Ping-Ping He;Zhenyu Zhong;Kristina Lindholm;Lilian Berning

  • Therapeutic approaches to Alzheimer's disease.

    Hans-Wolfgang Klafki;Matthias Staufenbiel;Johannes Kornhuber;Jens Wiltfang

  • TRANSMISSION AND SPREADING OF TAUOPATHIES IN TRANSGENIC MOUSE BRAIN

    Florence Clavaguera;Bernardino Ghetti;Gabriel Schweighauser;Hiroyasu Akatsu

Frequent Co-Authors

Paolo Paganetti
Paolo Paganetti Universita della Svizzera Italiana
Martin F. Bachmann
Martin F. Bachmann University of Bern
Paul M. Mathews
Paul M. Mathews New York University
Mathias Jucker
Mathias Jucker University of Tübingen
Nobuhisa Iwata
Nobuhisa Iwata Nagasaki University
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
Debby Van Dam
Debby Van Dam University of Antwerp
Lary C. Walker
Lary C. Walker Emory University
Peter Paul De Deyn
Peter Paul De Deyn University of Antwerp

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