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Biology and Biochemistry

D-Index
49
Citations
29524
World Ranking
17803
National Ranking
338

Overview

Paolo Paganetti is affiliated with Universita della Svizzera Italiana in Switzerland. Their research focuses primarily on Biochemistry, Genetics and Molecular Biology as well as Medicine, with significant contributions to Molecular Biology, Physiology, Neurology, Cell Biology, and Oncology.

The scientist's work explores a range of topics, including:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cancer-related Molecular Pathways
  • Extracellular vesicles in disease
  • Autophagy in Disease and Therapy
  • Cellular transport and secretion
  • Histone Deacetylase Inhibitors Research

Recent publications by Paolo Paganetti include:

  • Loss of TDP-43 oligomerization or RNA binding elicits distinct aggregation patterns, 2023, The EMBO Journal
  • Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer, 2020, Brain Sciences
  • Hijacking Endocytosis and Autophagy in Extracellular Vesicle Communication: Where the Inside Meets the Outside, 2021, Frontiers in Cell and Developmental Biology
  • ER -mitochondria contacts and cholesterol metabolism are disrupted by disease-associated tau protein, 2023, EMBO Reports
  • Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response, 2023, Scientific Data

The researcher frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, Frontiers in Cell and Developmental Biology, The EMBO Journal, and EMBO Reports.

Paolo Paganetti collaborates with several co-authors, including:

  • Stéphanie Papin
  • Martina Sola
  • Claudia Magrin
  • Ester Piovesana
  • Matteo Ciccaldo

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

    Christine Sturchler-Pierrat;Dorothee Abramowski;Mairead Duke;Karl-Heinz Wiederhold

  • Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.

    Melanie Meyer-Luehmann;Janaky Coomaraswamy;Tristan Bolmont;Tristan Bolmont;Stephan Kaeser

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.

    Maurizio Molinari;Verena Calanca;Carmela Galli;Paola Lucca

  • Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

    Hyunkyung Jeong;Florian Then;Thomas J. Melia;Joseph R. Mazzulli

  • Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

    Alfredo Lorenzo;Menglan Yuan;Zhuohua Zhang;Paolo A. Paganetti

  • Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.

    Christian Landles;Kirupa Sathasivam;Andreas Weiss;Ben Woodman

  • Membrane-type 1 Matrix Metalloprotease (MT1-MMP) Enables Invasive Migration of Glioma Cells in Central Nervous System White Matter

    Ann T.J. Beliën;Paolo A. Paganetti;Martin E. Schwab

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation.

    Tariq Afroz;Eva-Maria Hock;Patrick Ernst;Chiara Foglieni

  • Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER

    Maurizio Molinari;Carmela Galli;Verena Piccaluga;Michel Pieren

  • The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities

    H.-W. Klafki;D. Abramowski;R. Swoboda;P.A. Paganetti

  • EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

    Silvia Olivari;Tito Cali;Kirsi E.H. Salo;Paolo Paganetti

  • Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

    John Labbadia;Helen Cunliffe;Andreas Weiss;Elena Katsyuba

  • Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease

    Kirupa Sathasivam;Amin Lane;Justin Legleiter;Alice Warley

  • ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport

    Ilaria Fregno;Ilaria Fregno;Elisa Fasana;Timothy J Bergmann;Timothy J Bergmann;Andrea Raimondi

  • Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

    Ursula Bodendorf;Simone Danner;Frauke Fischer;Muriel Stefani

  • Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors *

    Andreas Weihofen;Marius K. Lemberg;Elena Friedmann;Heinrich Rueeger

Frequent Co-Authors

Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Maurizio Molinari
Maurizio Molinari Universita della Svizzera Italiana
Martin E. Schwab
Martin E. Schwab University of Zurich
Gillian P. Bates
Gillian P. Bates University College London
Evelina Gatti
Evelina Gatti Aix-Marseille University
Sergio Lavandero
Sergio Lavandero University of Chile
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
Steven M. Hersch
Steven M. Hersch Harvard University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Hsing Jien Kung
Hsing Jien Kung Taipei Medical University

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