D-Index & Metrics Best Publications
Biology and Biochemistry
Germany
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 137 Citations 77,270 420 World Ranking 123 National Ranking 9

Research.com Recognitions

Awards & Achievements

2022 - Research.com Biology and Biochemistry in Germany Leader Award

2018 - The Brain Prize, Lundbeck Foundation For their groundbreaking research on the genetic and molecular basis of Alzheimer’s disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the brain'

2015 - Metlife Foundation Award for Medical Research in Alzheimer's Disease

2003 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Agricultural and Nutritional Sciences

2002 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

2002 - Sedgwick Memorial Medal, American Public Health Association

2000 - Member of Academia Europaea

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His primary areas of study are Cell biology, Biochemistry, Presenilin, Molecular biology and Amyloid precursor protein secretase. Christian Haass has researched Cell biology in several fields, including Parkin, Protease and Neurodegeneration. His studies in Biochemistry integrate themes in fields like Alpha secretase and Senile plaques.

His Presenilin research includes themes of Membrane protein and Notch signaling pathway. His biological study spans a wide range of topics, including Genetics, Mutant, Gene and Transfection. His Amyloid precursor protein secretase study integrates concerns from other disciplines, such as Neuroscience and Ectodomain.

His most cited work include:

  • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. (3630 citations)
  • Amyloid β-peptide is produced by cultured cells during normal metabolism (1763 citations)
  • Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production (1595 citations)

What are the main themes of his work throughout his whole career to date?

Christian Haass spends much of his time researching Cell biology, Biochemistry, Presenilin, Pathology and Neurodegeneration. Christian Haass interconnects Transmembrane domain, Neuroscience and Amyloid precursor protein in the investigation of issues within Cell biology. His work investigates the relationship between Biochemistry and topics such as Amyloid precursor protein secretase that intersect with problems in Gamma secretase.

His Presenilin study combines topics in areas such as Molecular biology, Mutant and Amyloid. His Pathology research is multidisciplinary, relying on both Genetically modified mouse and In vivo. The Neurodegeneration study combines topics in areas such as Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis, TREM2, Microglia and Cognitive decline.

He most often published in these fields:

  • Cell biology (41.44%)
  • Biochemistry (28.10%)
  • Presenilin (22.14%)

What were the highlights of his more recent work (between 2018-2021)?

  • Microglia (18.68%)
  • TREM2 (18.52%)
  • Pathology (21.82%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Microglia, TREM2, Pathology, Disease and Internal medicine. His Microglia research incorporates themes from Amyloid, Phenotype, Neuroinflammation, Neuroscience and Amyloidosis. His Amyloid research is multidisciplinary, incorporating perspectives in Alzheimer's disease and Transgene.

His research integrates issues of Receptor, Innate immune system, Neurodegeneration and Cell biology in his study of TREM2. The concepts of his Cell biology study are interwoven with issues in Frontotemporal lobar degeneration, Neurotransmission, Peptide and Amyloid precursor protein. Christian Haass combines subjects such as Pi and In vivo with his study of Pathology.

Between 2018 and 2021, his most popular works were:

  • Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. (140 citations)
  • Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. (140 citations)
  • Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology (63 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

Christian Haass mainly investigates Microglia, TREM2, Cell biology, Neuroscience and Receptor. In his study, which falls under the umbrella issue of Microglia, Functional studies, Aβ deposition, Potential biomarkers, Phagocytosis and Proteome is strongly linked to Phenotype. His TREM2 research includes elements of Loss function, Neurodegeneration, Gene silencing, Monoclonal antibody and Amyloid.

His work carried out in the field of Amyloid brings together such families of science as Endocrinology, Cerebrospinal fluid and Neuroinflammation. His research in Cell biology is mostly focused on Protein folding. His Genetically modified mouse research extends to the thematically linked field of Neuroscience.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.

Christian Haass;Dennis J. Selkoe.
Nature Reviews Molecular Cell Biology (2007)

5919 Citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

Christian Haass;Michael G. Schlossmacher;Michael G. Schlossmacher;Albert Y. Hung;Carmen Vigo-Pelfrey.
Nature (1992)

2519 Citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron;Tilman Oltersdorf;Christian Haass;Lisa McConlogue.
Nature (1992)

2340 Citations

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Sven Lammich;Elzbieta Kojro;Rolf Postina;Sandra Gilbert.
Proceedings of the National Academy of Sciences of the United States of America (1999)

1557 Citations

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

Robert Ehehalt;Patrick Keller;Christian Haass;Christoph Thiele.
Journal of Cell Biology (2003)

1253 Citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

Christian Haass;Edward H. Koo;Angela Mellon;Albert Y. Hung.
Nature (1992)

1232 Citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

Christian Haass;Dennis J. Selkoe.
Cell (1993)

1160 Citations

Reconstitution of γ-secretase activity

Dieter Edbauer;Edith Winkler;Joerg T. Regula;Brigitte Pesold.
Nature Cell Biology (2003)

1120 Citations

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

Kohji Mori;Shih-Ming Weng;Thomas Arzberger;Stephanie May.
Science (2013)

1008 Citations

Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

Rebecca Radde;Tristan Bolmont;Stephan A Kaeser;Janaky Coomaraswamy.
EMBO Reports (2006)

939 Citations

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