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Neuroscience
Japan
2026
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Biology and Biochemistry
Japan
2023

D-Index & Metrics

Neuroscience

D-Index
131
Citations
61249
World Ranking
271
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Japan Leader Award
  • 2025 - Research.com Neuroscience in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Takaomi C. Saido is affiliated with the RIKEN Center for Brain Science in Japan. Their research primarily focuses on the fields of medicine, neuroscience, and biochemistry, genetics, and molecular biology. Subfields of study include physiology, molecular biology, neurology, cellular and molecular neuroscience, and cognitive neuroscience.

Their work covers several main topics, notably Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, cholinesterase and neurodegenerative diseases, tryptophan and brain disorders, memory and neural mechanisms, and dementia and cognitive impairment research.

Frequent publication venues for Saido's work include bioRxiv (Cold Spring Harbor Laboratory), Alzheimer's & Dementia, Journal of Alzheimer's Disease, Scientific Reports, and eLife.

They have collaborated notably with several researchers, with frequent coauthors including Takashi Saito, Hiroki Sasaguri, Naoto Watamura, Shoko Hashimoto, and Naoko Kamano.

Significant recent papers include:

  • Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease, 2020, Cell
  • Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease, 2023, Nature
  • Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues, 2020, Nature Communications
  • Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease, 2021, Acta Neuropathologica Communications
  • Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model, 2021, Molecular Neurodegeneration

Best Publications

  • Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

    Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  • Metabolic Regulation of Brain Aβ by Neprilysin

    Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki;Keiro Shirotani

  • Single App knock-in mouse models of Alzheimer's disease

    Takashi Saito;Yukio Matsuba;Naomi Mihira;Jiro Takano

  • Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

    Takeshi Kawarabayashi;Takeshi Kawarabayashi;Linda H. Younkin;Takaomi C. Saido;Mikio Shoji

  • Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition.

    Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki;Kaori Watanabe

  • Calpain: new perspectives in molecular diversity and physiological-pathological involvement.

    Takaomi C. Saido;Hiroyuki Sorimachi;Koichi Suzuki

  • Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

    Wei-Ting Chen;Wei-Ting Chen;Ashley Lu;Ashley Lu;Katleen Craessaerts;Katleen Craessaerts;Benjamin Pavie

  • The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

    Carlo Sala Frigerio;Carlo Sala Frigerio;Leen Wolfs;Nicola Fattorelli;Nicola Thrupp

  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

    Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  • APP mouse models for Alzheimer's disease preclinical studies

    Hiroki Sasaguri;Hiroki Sasaguri;Per Nilsson;Per Nilsson;Shoko Hashimoto;Kenichi Nagata

  • Microglial response to amyloid plaques in APPsw transgenic mice.

    Sally A. Frautschy;Fusheng Yang;Michael Irrizarry;Brad Hyman

  • Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

    Takaomi C Saido;Takeshi Iwatsubo;David M.A Mann;Hiroyuki Shimada

  • Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

    Seamus J. Martin;Geraldine A. O'Brien;Walter K. Nishioka;Anne J. McGahon

  • Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation

    C.A. Lemere;J.K. Blusztajn;H. Yamaguchi;T. Wisniewski

  • Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

    Ross Nortley;Nils Korte;Pablo Izquierdo;Chanawee Hirunpattarasilp

  • The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

    Lemere Ca;Lopera F;Kosik Ks;Lendon Cl

  • ScaleS: an optical clearing palette for biological imaging

    Hiroshi Hama;Hiroyuki Hioki;Kana Namiki;Tetsushi Hoshida

  • A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin.

    S.-I. Osada;K. Mizuno;T. C. Saido;Y. Akita

  • The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

    Taisuke Tomita;Kei Maruyama;Takaomi C. Saido;Hideaki Kume

  • An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

    Shi Du Yan;Jin Fu;Claudio Soto;Xi Chen

  • Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

    Yue Qi-Takahara;Maho Morishima-Kawashima;Yu Tanimura;Georgia Dolios

Frequent Co-Authors

Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Matthias Staufenbiel
Matthias Staufenbiel University of Tübingen
Shin-ichi Muramatsu
Shin-ichi Muramatsu Jichi Medical University
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Kunihiko Obata
Kunihiko Obata The Graduate University for Advanced Studies, SOKENDAI
Rudi D'Hooge
Rudi D'Hooge KU Leuven
Tetsuya Suhara
Tetsuya Suhara National Institutes for Quantum and Radiological Science and Technology

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