Hiroyuki Sorimachi mostly deals with Calpain, Biochemistry, Cell biology, Molecular biology and Protein subunit. His Calpain research includes themes of Enzyme activator, Autolysis, Proteolysis, Gene and Binding site. Hiroyuki Sorimachi interconnects Amyloid precursor protein secretase and Alpha secretase in the investigation of issues within Biochemistry.
His work on Titin as part of his general Cell biology study is frequently connected to Physiological function, thereby bridging the divide between different branches of science. His Molecular biology study frequently draws connections to other fields, such as Complementary DNA. His Protein subunit study incorporates themes from Binding domain and Skeletal muscle.
Hiroyuki Sorimachi mostly deals with Calpain, Biochemistry, Cell biology, Molecular biology and Protease. The study incorporates disciplines such as Proteases, Protein subunit, Proteolysis, Intracellular and Skeletal muscle in addition to Calpain. His Protein subunit study combines topics in areas such as Isozyme and Recombinant DNA.
His works in Titin and Endoplasmic reticulum are all subjects of inquiry into Cell biology. Hiroyuki Sorimachi focuses mostly in the field of Molecular biology, narrowing it down to matters related to Complementary DNA and, in some cases, Myotonin-protein kinase. Hiroyuki Sorimachi combines subjects such as Enzyme activator, Calpastatin, Mutant, Muscular dystrophy and Protein structure with his study of Protease.
His scientific interests lie mostly in Calpain, Protease, Cell biology, Biochemistry and Proteases. His Calpain research incorporates elements of Cysteine protease, Proteolysis, Molecular biology, Intracellular and Skeletal muscle. The Skeletal muscle study combines topics in areas such as Myocyte, Titin, Enzyme activator and Autolysis.
His work carried out in the field of Protease brings together such families of science as Complementation, Genetics, Muscular dystrophy and Muscle contraction. His biological study spans a wide range of topics, including Cytosol, Myofibril, Disease and Calpain-2. His research integrates issues of SUPERFAMILY, Apoptosis and Calpastatin in his study of Proteases.
The scientist’s investigation covers issues in Calpain, Protease, Proteases, Biochemistry and Proteolysis. His Calpain study combines topics from a wide range of disciplines, such as Cleavage, Cysteine protease, Cell biology, Pharmacology and Drug discovery. His Cell biology research is multidisciplinary, incorporating perspectives in Muscular dystrophy, Mutant protein, Myofibril and Anatomy.
The various areas that he examines in his Protease study include Molecular biology, Downregulation and upregulation and Pathogenesis. Hiroyuki Sorimachi focuses mostly in the field of Proteases, narrowing it down to topics relating to Enzyme activator and, in certain cases, Genetic model, Muscular Disorders, Cytosol, Disease and Skeletal muscle. His Proteolysis research integrates issues from SUPERFAMILY, Neuroscience, Intracellular and Proteasome.
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Structure and physiological function of calpains
Hiroyuki Sorimachi;Shoichi Ishiura;Koichi Suzuki.
Biochemical Journal (1997)
Calpain: new perspectives in molecular diversity and physiological-pathological involvement.
Takaomi C. Saido;Hiroyuki Sorimachi;Koichi Suzuki.
The FASEB Journal (1994)
Structure, Activation, and Biology of Calpain
Koichi Suzuki;Shoji Hata;Yukiko Kawabata;Hiroyuki Sorimachi.
Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.
H Sorimachi;S Imajoh-Ohmi;S Imajoh-Ohmi;Y Emori;H Kawasaki.
Journal of Biological Chemistry (1989)
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
Stefan Strobl;Carlos Fernandez-Catalan;Marianne Braun;Robert Huber.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.
Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny.
Journal of Molecular Biology (2001)
Muscle assembly: a titanic achievement?
Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit.
Current Opinion in Cell Biology (1999)
Muscle-specific Calpain, p94, Responsible for Limb Girdle Muscular Dystrophy Type 2A, Associates with Connectin through IS2, a p94-specific Sequence
Hiroyuki Sorimachi;Kayoko Kinbara;Sumiko Kimura;Miwako Takahashi.
Journal of Biological Chemistry (1995)
Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.
Hisashi Koike;Shigeo Tomioka;Hiroyuki Sorimachi;Takaomi C. Saido.
Biochemical Journal (1999)
The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity.
Carol C. Gregorio;Karoly Trombitás;Thomas Centner;Bernhard Kolmerer.
Journal of Cell Biology (1998)
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