D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 68 Citations 16,058 160 World Ranking 3464 National Ranking 224

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

Hiroyuki Sorimachi mostly deals with Calpain, Biochemistry, Cell biology, Molecular biology and Protein subunit. His Calpain research includes themes of Enzyme activator, Autolysis, Proteolysis, Gene and Binding site. Hiroyuki Sorimachi interconnects Amyloid precursor protein secretase and Alpha secretase in the investigation of issues within Biochemistry.

His work on Titin as part of his general Cell biology study is frequently connected to Physiological function, thereby bridging the divide between different branches of science. His Molecular biology study frequently draws connections to other fields, such as Complementary DNA. His Protein subunit study incorporates themes from Binding domain and Skeletal muscle.

His most cited work include:

  • Structure and physiological function of calpains (646 citations)
  • Calpain: new perspectives in molecular diversity and physiological-pathological involvement. (607 citations)
  • Structure, Activation, and Biology of Calpain (335 citations)

What are the main themes of his work throughout his whole career to date?

Hiroyuki Sorimachi mostly deals with Calpain, Biochemistry, Cell biology, Molecular biology and Protease. The study incorporates disciplines such as Proteases, Protein subunit, Proteolysis, Intracellular and Skeletal muscle in addition to Calpain. His Protein subunit study combines topics in areas such as Isozyme and Recombinant DNA.

His works in Titin and Endoplasmic reticulum are all subjects of inquiry into Cell biology. Hiroyuki Sorimachi focuses mostly in the field of Molecular biology, narrowing it down to matters related to Complementary DNA and, in some cases, Myotonin-protein kinase. Hiroyuki Sorimachi combines subjects such as Enzyme activator, Calpastatin, Mutant, Muscular dystrophy and Protein structure with his study of Protease.

He most often published in these fields:

  • Calpain (62.18%)
  • Biochemistry (38.86%)
  • Cell biology (31.61%)

What were the highlights of his more recent work (between 2009-2020)?

  • Calpain (62.18%)
  • Protease (26.94%)
  • Cell biology (31.61%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Calpain, Protease, Cell biology, Biochemistry and Proteases. His Calpain research incorporates elements of Cysteine protease, Proteolysis, Molecular biology, Intracellular and Skeletal muscle. The Skeletal muscle study combines topics in areas such as Myocyte, Titin, Enzyme activator and Autolysis.

His work carried out in the field of Protease brings together such families of science as Complementation, Genetics, Muscular dystrophy and Muscle contraction. His biological study spans a wide range of topics, including Cytosol, Myofibril, Disease and Calpain-2. His research integrates issues of SUPERFAMILY, Apoptosis and Calpastatin in his study of Proteases.

Between 2009 and 2020, his most popular works were:

  • Calpains: an elaborate proteolytic system. (217 citations)
  • Calpain research for drug discovery: challenges and potential (129 citations)
  • Calpain chronicle-an enzyme family under multidisciplinary characterization (102 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

The scientist’s investigation covers issues in Calpain, Protease, Proteases, Biochemistry and Proteolysis. His Calpain study combines topics from a wide range of disciplines, such as Cleavage, Cysteine protease, Cell biology, Pharmacology and Drug discovery. His Cell biology research is multidisciplinary, incorporating perspectives in Muscular dystrophy, Mutant protein, Myofibril and Anatomy.

The various areas that he examines in his Protease study include Molecular biology, Downregulation and upregulation and Pathogenesis. Hiroyuki Sorimachi focuses mostly in the field of Proteases, narrowing it down to topics relating to Enzyme activator and, in certain cases, Genetic model, Muscular Disorders, Cytosol, Disease and Skeletal muscle. His Proteolysis research integrates issues from SUPERFAMILY, Neuroscience, Intracellular and Proteasome.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Structure and physiological function of calpains

Hiroyuki Sorimachi;Shoichi Ishiura;Koichi Suzuki.
Biochemical Journal (1997)

916 Citations

Calpain: new perspectives in molecular diversity and physiological-pathological involvement.

Takaomi C. Saido;Hiroyuki Sorimachi;Koichi Suzuki.
The FASEB Journal (1994)

838 Citations

Structure, Activation, and Biology of Calpain

Koichi Suzuki;Shoji Hata;Yukiko Kawabata;Hiroyuki Sorimachi.
Diabetes (2004)

502 Citations

Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.

H Sorimachi;S Imajoh-Ohmi;S Imajoh-Ohmi;Y Emori;H Kawasaki.
Journal of Biological Chemistry (1989)

494 Citations

The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

Stefan Strobl;Carlos Fernandez-Catalan;Marianne Braun;Robert Huber.
Proceedings of the National Academy of Sciences of the United States of America (2000)

436 Citations

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny.
Journal of Molecular Biology (2001)

428 Citations

Muscle assembly: a titanic achievement?

Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit.
Current Opinion in Cell Biology (1999)

420 Citations

Muscle-specific Calpain, p94, Responsible for Limb Girdle Muscular Dystrophy Type 2A, Associates with Connectin through IS2, a p94-specific Sequence

Hiroyuki Sorimachi;Kayoko Kinbara;Sumiko Kimura;Miwako Takahashi.
Journal of Biological Chemistry (1995)

395 Citations

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.

Hisashi Koike;Shigeo Tomioka;Hiroyuki Sorimachi;Takaomi C. Saido.
Biochemical Journal (1999)

387 Citations

The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity.

Carol C. Gregorio;Karoly Trombitás;Thomas Centner;Bernhard Kolmerer.
Journal of Cell Biology (1998)

359 Citations

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