World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
17833
World Ranking
5972
National Ranking
380

Overview

Hiroyuki Sorimachi is affiliated with the Tokyo Metropolitan Institute of Medical Science in Japan. Their research contributions span notable fields including Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology. Within these broad fields, their work further focuses on subfields such as Immunology, Molecular Biology, Genetics, Cell Biology, and Animal Science and Zoology.

The scientist's research interests encompass several specialized topics. These include:

  • Ubiquitin and proteasome pathways
  • Genetics and neurodevelopmental disorders
  • Biochemical and molecular research
  • Calpain protease function and regulation
  • Meat and animal product quality
  • Venomous animal envenomation and studies
  • Immune cell function and interaction

Hiroyuki Sorimachi has been involved in publishing research in multiple peer-reviewed venues, with recent contributions to journals such as Nature Communications, Biology Open, and Frontiers in Immunology. Some of their recent papers include:

  • The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3, 2022, Nature Communications
  • Developing fluorescence sensor probe to capture activated muscle-specific calpain-3 (CAPN3) in living muscle cells, 2020, Biology Open
  • Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function, 2024, Frontiers in Immunology

Their collaborative network includes frequent coauthors such as Yasuko Ono, Ryosuke Ishimura, Afnan H. El-Gowily, Daisuke Noshiro, and Satoko Komatsu-Hirota, reflecting ongoing collaborative efforts within their research community.

The span and variety of their publications indicate active engagement with both molecular mechanisms and immunological processes, integrating biochemical pathways and cellular functions in their research portfolio.

Best Publications

  • Structure and physiological function of calpains

    Hiroyuki Sorimachi;Shoichi Ishiura;Koichi Suzuki

  • Calpain: new perspectives in molecular diversity and physiological-pathological involvement.

    Takaomi C. Saido;Hiroyuki Sorimachi;Koichi Suzuki

  • Structure, Activation, and Biology of Calpain

    Koichi Suzuki;Shoji Hata;Yukiko Kawabata;Hiroyuki Sorimachi

  • Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.

    H Sorimachi;S Imajoh-Ohmi;S Imajoh-Ohmi;Y Emori;H Kawasaki

  • Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

    Thomas Centner;Junko Yano;Eiichi Kimura;Abigail S. McElhinny

  • The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium

    Stefan Strobl;Carlos Fernandez-Catalan;Marianne Braun;Robert Huber

  • Muscle assembly: a titanic achievement?

    Carol C Gregorio;Henk Granzier;Hiroyuki Sorimachi;Siegfried Labeit

  • Muscle-specific Calpain, p94, Responsible for Limb Girdle Muscular Dystrophy Type 2A, Associates with Connectin through IS2, a p94-specific Sequence

    Hiroyuki Sorimachi;Kayoko Kinbara;Sumiko Kimura;Miwako Takahashi

  • Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein.

    Hisashi Koike;Shigeo Tomioka;Hiroyuki Sorimachi;Takaomi C. Saido

  • Calpains: an elaborate proteolytic system.

    Yasuko Ono;Hiroyuki Sorimachi

  • The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity.

    Carol C. Gregorio;Karoly Trombitás;Thomas Centner;Bernhard Kolmerer

  • The structure of calpain.

    Hiroyuki Sorimachi;Koichi Suzuki

  • Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.

    Abigail S. McElhinny;Kazumi Kakinuma;Hiroyuki Sorimachi;Siegfried Labeit

  • Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

    Marie Louise Bang;Ryan E. Mudry;Abigail S. McElhinny;Karoly Trombitás

  • Muscle-specific calpain, p94, is degraded by autolysis immediately after translation, resulting in disappearance from muscle.

    H. Sorimachi;N. Toyama-Sorimachi;T. C. Saido;H. Kawasaki

  • Calpain: novel family members, activation, and physiologic function.

    K Suzuki;H Sorimachi;T Yoshizawa;K Kinbara

  • A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation.

    Noriko Toyama-Sorimachi;Hiroyuki Sorimachi;Yoshimi Tobita;Fujiko Kitamura

  • Calpain research for drug discovery: challenges and potential

    Yasuko Ono;Takaomi C. Saido;Hiroyuki Sorimachi

  • Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs

    H. Sorimachi;A. Freiburg;Bernhard Kolmerer;S. Ishiura

  • New era of calpain research. Discovery of tissue-specific calpains.

    Hiroyuki Sorimachi;Takaomi C. Saido;Koichi Suzuki

Frequent Co-Authors

Koichi Suzuki
Koichi Suzuki University of Tokyo
Shoichi Ishiura
Shoichi Ishiura University of Tokyo
Keiko Abe
Keiko Abe University of Tokyo
Siegfried Labeit
Siegfried Labeit European Bioinformatics Institute
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Carol C. Gregorio
Carol C. Gregorio University of Arizona
Yasufumi Emori
Yasufumi Emori University of Tokyo
Henk Granzier
Henk Granzier University of Arizona
Hiroshi Kawasaki
Hiroshi Kawasaki Keio University
Katsuhiko Kitamoto
Katsuhiko Kitamoto Nihon Pharmaceutical University

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