Melissa J. Spencer

Overview

Best Publications

• A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice

  Michelle Wehling;Melissa J. Spencer;James G. Tidball

  634
  Citations

• Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy

  Wen Jinn Chang;Susan T. Iannaccone;Kim S. Lau;Bettie Sue S Masters

  432
  Citations

• A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells

  Courtney S. Young;Michael R. Hicks;Natalia V. Ermolova;Haruko Nakano

  424
  Citations

• Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-β

  Sylvia A. Vetrone;Encarnacion Montecino-Rodriguez;Elena Kudryashova;Irina Kramerova

  327
  Citations

• Helper (CD4(+)) and cytotoxic (CD8(+)) T cells promote the pathology of dystrophin-deficient muscle.

  Melissa J. Spencer;Encarnacion Montecino-Rodriguez;Kenneth Dorshkind;James G. Tidball

  319
  Citations

• Mechanical loading regulates NOS expression and activity in developing and adult skeletal muscle

  James G. Tidball;Eliane Lavergne;Kim S. Lau;Melissa J. Spencer

  287
  Citations

• Apoptosis precedes necrosis of dystrophin-deficient muscle

  J.G. Tidball;D.E. Albrecht;B.E. Lokensgard;M.J. Spencer

  284
  Citations

• CALPAINS ARE ACTIVATED IN NECROTIC FIBERS FROM MDX DYSTROPHIC MICE

  Melissa J. Spencer;Dorothy E. Croall;James G. Tidball

  277
  Citations

• Expression of a calpastatin transgene slows muscle wasting and obviates changes in myosin isoform expression during murine muscle disuse.

  James G. Tidball;Melissa J. Spencer

  261
  Citations

• Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy

  S. Armando Villalta;Wendy Rosenthal;Leonel Martinez;Amanjot Kaur

  252
  Citations

• Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.

  Elena Kudryashova;Dmitri Kudryashov;Irina Kramerova;Melissa J. Spencer

  248
  Citations

• Do immune cells promote the pathology of dystrophin-deficient myopathies?

  Melissa J Spencer;James G Tidball

  232
  Citations

• Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

  I. Kramerova;E. Kudryashova;J.G. Tidball;Melissa J. Spencer

  225
  Citations

• Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology

  Melissa J. Spencer;Ronald L. Mellgren

  225
  Citations

• Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity.

  M J Spencer;C M Walsh;K A Dorshkind;E M Rodriguez

  207
  Citations

• Calpain 3 participates in sarcomere remodeling by acting upstream of the ubiquitin–proteasome pathway

  Irina Kramerova;Elena Kudryashova;Gayathri Venkatraman;Melissa J. Spencer

  191
  Citations

• Calpains and muscular dystrophies.

  James G Tidball;Melissa J Spencer

  186
  Citations

• Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.

  Jacques S. Beckmann;Melissa Spencer

  178
  Citations

• ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs.

  Michael R Hicks;Julia Hiserodt;Katrina Paras;Wakana Fujiwara

  170
  Citations

• Review article Do immune cells promote the pathology of dystrophin-deficient myopathies?

  Melissa J. Spencer;James G. Tidball

  0
  Citations