World's Best Scientists 2026 revealed!
Jeffrey S. Chamberlain

Jeffrey S. Chamberlain

D-Index & Metrics

Molecular Biology

D-Index
102
Citations
31080
World Ranking
499
National Ranking
278

Medicine

D-Index
102
Citations
31085
World Ranking
7759
National Ranking
4044

Overview

Jeffrey S. Chamberlain is affiliated with the University of Washington in the United States. Their research primarily focuses on biochemistry, genetics, molecular biology, and medicine, with a particular emphasis on molecular biology and genetics within these fields.

The scientist's work spans several subfields, including molecular biology, genetics, cardiology and cardiovascular medicine, physiology, and epidemiology. Their research explores diverse topics such as muscle physiology and disorders, virus-based gene therapy research, viral infectious diseases and gene expression in insects, viral infections and immunology research, adipose tissue and metabolism, cardiomyopathy and myosin studies, and autophagy in disease and therapy.

Chamberlain has contributed to multiple research papers in notable publication venues. Frequent venues for their publications include Molecular Therapy, Molecular Therapy - Methods & Clinical Development, Skeletal Muscle, UNC Libraries, and Nature Metabolism.

Recent publications authored by or including Chamberlain are:

  • Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy, 2023, Science Translational Medicine
  • PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing, 2023, Nature Metabolism
  • Split intein-mediated protein trans-splicing to express large dystrophins, 2024, Nature
  • Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model, 2021, JCI Insight
  • Enveloped viruses pseudotyped with mammalian myogenic cell fusogens target skeletal muscle for gene delivery, 2023, Cell

Their research collaborations include frequent coauthors:

  • Julie M. Crudele
  • Stephen D. Hauschka
  • Hichem Tasfaout
  • Guy L. Odom
  • Kristy J. Brown

Chamberlain's studies contribute to understanding muscle physiology and disorders through virus-based gene therapy methods, particularly gene therapies targeting Duchenne muscular dystrophy models. The work also includes advancing viral gene delivery systems and the biochemical pathways relevant to muscle health and ageing.

Best Publications

  • Deletion screening of the Duchenne muscular dystrophy locus via multiplex DNA amplification

    Jeffrey S. Chamberlain;Richard A. Gibbs;Joel E. Rainer;Phi Nga Nguyen;Phi Nga Nguyen

  • Characterization of dystrophin in muscle-biopsy specimens from patients with Duchenne's or Becker's muscular dystrophy

    Hoffman Ep;Fischbeck Kh;Brown Rh;Johnson M

  • Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells.

    Arianna Dellavalle;Maurilio Sampaolesi;Rossana Tonlorenzi;Enrico Tagliafico

  • Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

    Paul Gregorevic;Michael J Blankinship;James M Allen;Robert W Crawford

  • Modular flexibility of dystrophin: Implications for gene therapy of Duchenne muscular dystrophy

    Scott Q. Harper;Michael A. Hauser;Michael A. Hauser;Christiana DelloRusso;Christiana DelloRusso;Dongsheng Duan

  • X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus.

    J. A. Towbin;J. F. Hejtmancik;P. Brink;B. Gelb

  • Animal models for muscular dystrophy show different patterns of sarcolemmal disruption

    Volker Straub;Jill A. Rafael;Jeffrey S. Chamberlain;Kevin P. Campbell

  • Identification and Characterization of the Dystrophin Anchoring Site on β-Dystroglycan

    Daniel Jung;Bin Yang;Bin Yang;Jon Meyer;Jon Meyer;Jeffrey S. Chamberlain

  • Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

    Yi Lai;Gail D. Thomas;Yongping Yue;Hsiao T. Yang

  • Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy.

    Niclas E. Bengtsson;John K. Hall;Guy L. Odom;Michael P. Phelps

  • rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

    Paul Gregorevic;James M Allen;Elina Minami;Michael J Blankinship

  • Dystrophin-deficient mdx mice display a reduced life span and are susceptible to spontaneous rhabdomyosarcoma

    Jeffrey S. Chamberlain;Joseph Metzger;Morayma Reyes;De Wayne Townsend

  • Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity

    Gregory A. Cox;Neil M. Cole;Kiichiro Matsumura;Stephanie F. Phelps

  • Production and Characterization of Improved Adenovirus Vectors with the E1, E2b, and E3 Genes Deleted

    Andrea Amalfitano;Michael A. Hauser;Huimin Hu;Delila Serra

  • Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice

    Stephanie F. Phelps;Michael A. Hauser;Neil M. Cole;Jill A. Rafael

  • Force and power output of fast and slow skeletal muscles from mdx mice 6‐28 months old

    Gordon S. Lynch;Richard T. Hinkle;Jeffrey S. Chamberlain;Susan V. Brooks

  • 33 – MULTIPLEX PCR FOR THE DIAGNOSIS OF DUCHENNE MUSCULAR DYSTROPHY

    Jeffrey S. Chamberlain;Richard A. Gibbs;Joel E. Ranier;C. Thomas Caskey

  • Sarcolemma-localized nNOS is required to maintain activity after mild exercise

    Yvonne M. Kobayashi;Erik P. Rader;Robert W. Crawford;Nikhil K. Iyengar

  • High levels of AAV vector integration into CRISPR-induced DNA breaks

    Killian S. Hanlon;Benjamin P. Kleinstiver;Sara P. Garcia;Mikołaj P. Zaborowski;Mikołaj P. Zaborowski

  • Carrier detection and prenatal diagnosis in Duchenne and Becker muscular dystrophy families, using dinucleotide repeat polymorphisms

    P. R. Clemens;R. G. Fenwick;J. S. Chamberlain;R. A. Gibbs

Frequent Co-Authors

Paul Gregorevic
Paul Gregorevic University of Melbourne
Stephen D. Hauschka
Stephen D. Hauschka University of Washington
Stephen J. Tapscott
Stephen J. Tapscott Fred Hutchinson Cancer Research Center
Kevin P. Campbell
Kevin P. Campbell University of Iowa
John A. Faulkner
John A. Faulkner University of Michigan–Ann Arbor
Dongsheng Duan
Dongsheng Duan University of Missouri
Rainer Storb
Rainer Storb Fred Hutchinson Cancer Research Center
Michael A. Hauser
Michael A. Hauser Duke University
Yongping Yue
Yongping Yue University of Missouri
Louis M. Kunkel
Louis M. Kunkel Boston Children's Hospital

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