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Biology and Biochemistry

D-Index
69
Citations
18448
World Ranking
7332
National Ranking
3359

Overview

Stephen D. Hauschka is affiliated with the University of Washington in the United States. Their research primarily focuses on the intersections of biochemistry, genetics, and molecular biology, with notable contributions in medicine as well. The scientist's work spans several subfields, including molecular biology, genetics, surgery, pathology and forensic medicine, and aging.

The main topics addressed in Hauschka's research include muscle physiology and disorders, virus-based gene therapy, CRISPR and genetic engineering, tissue engineering and regenerative medicine, viral infectious diseases and gene expression in insects, pluripotent stem cells research, and cardiac ischemia and reperfusion.

Significant recent publications by Hauschka include:

  • Assessment of systemic AAV-microdystrophin gene therapy in the GRMD model of Duchenne muscular dystrophy (2023, Science Translational Medicine)
  • In Vivo Gene Editing of Muscle Stem Cells with Adeno-Associated Viral Vectors in a Mouse Model of Duchenne Muscular Dystrophy (2020, Molecular Therapy - Methods & Clinical Development)
  • Split intein-mediated protein trans-splicing to express large dystrophins (2024, Nature)
  • Dystrophin Gene-Editing Stability Is Dependent on Dystrophin Levels in Skeletal but Not Cardiac Muscles (2020, Molecular Therapy)
  • Targeted CRISPR activation is functional in engineered human pluripotent stem cells but undergoes silencing after differentiation into cardiomyocytes and endothelium (2024, Cellular and Molecular Life Sciences)

Hauschka frequently publishes in venues such as Molecular Therapy, Science Translational Medicine, Nature, Molecular Therapy - Methods & Clinical Development, and Cellular and Molecular Life Sciences.

In collaboration, Hauschka has worked often with several researchers, including Jeffrey S. Chamberlain, Michael Regnier, Charles E. Murry, Julie M. Crudele, and Hichem Tasfaout.

Best Publications

  • Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.

    Cornelis Murre;Patrick Schonleber McCaw;H. Vaessin;M. Caudy

  • MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

    Andrew B. Lassar;Jean N. Buskin;Daniel Lockshon;Robert L. Davis

  • Skeletal myoblast transplantation for repair of myocardial necrosis.

    Charles E. Murry;Robert W. Wiseman;Stephen M. Schwartz;Stephen D. Hauschka

  • Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

    Christopher H. Clegg;Thomas A. Linkhart;Bradley B. Olwin;Stephen D. Hauschka

  • The influence of collagen on the development of muscle clones.

    Stephen D. Hauschka;Irwin R. Konigsberg

  • Electromechanical coupling between skeletal and cardiac muscle. Implications for infarct repair.

    Hans Reinecke;Glen H. MacDonald;Stephen D. Hauschka;Charles E. Murry

  • Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

    Eun-Gyoung Hong;Hwi Jin Ko;Hwi Jin Ko;You-Ree Cho;You-Ree Cho;Hyo-Jeong Kim;Hyo-Jeong Kim

  • Identification of a myocyte nuclear factor that binds to the muscle-specific enhancer of the mouse muscle creatine kinase gene.

    J N Buskin;S D Hauschka

  • Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts.

    Bradley B. Olwin;Stephen D. Hauschka

  • Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy.

    Niclas E. Bengtsson;John K. Hall;Guy L. Odom;Michael P. Phelps

  • Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity

    Gregory A. Cox;Neil M. Cole;Kiichiro Matsumura;Stephanie F. Phelps

  • The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.

    J B Jaynes;J E Johnson;J N Buskin;C L Gartside

  • Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice.

    Jane E. Johnson;Barbara J. Wold;Stephen D. Hauschka

  • Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation

    Richard L. Frock;Brian A. Kudlow;Angela M. Evans;Samantha A. Jameson

  • Laminin alters cell shape and stimulates motility and proliferation of murine skeletal myoblasts.

    Mücella Öcalan;Simon L. Goodman;Uwe Kühl;Stephen D. Hauschka

  • In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces

    Todd C. McDevitt;John C. Angello;Marsha L. Whitney;Hans Reinecke

  • Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair.

    Todd C. McDevitt;Kimberly A. Woodhouse;Stephen D. Hauschka;Charles E. Murry

  • Clonal analysis of vertebrate myogenesis. I. Early developmental events in the chick limb.

    Philip H. Bonner;Stephen D. Hauschka

  • Design of tissue-specific regulatory cassettes for high-level rAAV-mediated expression in skeletal and cardiac muscle.

    Maja Z. Salva;Charis L. Himeda;Phillip W L Tai;Eiko Nishiuchi

  • Myogenesis in paraxial mesoderm: Preferential induction by dorsal neural tube and by cells expressing Wnt-1

    Howard M. Stern;Anthony M. C. Brown;Stephen D. Hauschka

Frequent Co-Authors

Jeffrey S. Chamberlain
Jeffrey S. Chamberlain University of Washington
Charles E. Murry
Charles E. Murry University of Washington
Jane E. Johnson
Jane E. Johnson The University of Texas Southwestern Medical Center
Bradley B. Olwin
Bradley B. Olwin University of Colorado Boulder
Jeffrey A. Ranish
Jeffrey A. Ranish University of Washington
William A. Catterall
William A. Catterall University of Washington
Michael Regnier
Michael Regnier University of Washington
Nadia Rosenthal
Nadia Rosenthal National Institutes of Health
Todd C. McDevitt
Todd C. McDevitt University of California, San Francisco
Patrick S. Stayton
Patrick S. Stayton University of Washington

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