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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
12999
World Ranking
14306
National Ranking
6031

Research.com Recognitions

  • 2016 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Michael Regnier is affiliated with the University of Washington in the United States. Their research spans multiple fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Cardiology and Cardiovascular Medicine as well as Molecular Biology. Their work encompasses surgery, atomic and molecular physics, and electrical and electronic engineering to a lesser extent.

The primary topics of Michael Regnier's research include cardiomyopathy and myosin studies, muscle physiology and disorders, cardiovascular effects of exercise, and cardiovascular function and risk factors. Additional research interests cover force microscopy techniques and applications, congenital heart defects, and cellular mechanics and interactions.

Michael Regnier has contributed to numerous publications across several well-known scientific venues. Among the most frequent publication platforms are Biophysical Journal with 73 publications, bioRxiv (Cold Spring Harbor Laboratory) with 21, Journal of Molecular and Cellular Cardiology with 14, Circulation and Proceedings of the National Academy of Sciences each with 5 publications.

Collaborations have been established extensively, with frequent coauthors including Matthew C. Childers, Saffie Mohran, Farid Moussavi-Harami, Timothy S. McMillen, and Michael A. Geeves. These collaborations indicate ongoing partnerships in related areas of muscle biophysics and cardiovascular research.

Recent representative papers by Michael Regnier demonstrate a focus on myosin and cardiac muscle physiology:

  • "Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy" (2020, Circulation)
  • "Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle" (2022, Journal of Biological Chemistry)
  • "Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force" (2023, Proceedings of the National Academy of Sciences)
  • "Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments" (2020, Biophysical Journal)
  • "The Sliding Filament Theory Since Andrew Huxley: Multiscale and Multidisciplinary Muscle Research" (2021, Annual Review of Biophysics)

Michael Regnier has also contributed to book publications, including a title published by Springer Science+Business Media:

  • "Familial Cardiomyopathies" (2023)

They have received recognition such as being named Fellow of the Indian National Academy of Engineering (INAE) in 2016.

Best Publications

  • Regulation of Contraction in Striated Muscle

    A. M. Gordon;E. Homsher;M. Regnier

  • Structural and Functional Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells

    Scott D. Lundy;Wei Zhong Zhu;Michael Regnier;Michael A. Laflamme

  • Growth of Engineered Human Myocardium With Mechanical Loading and Vascular Coculture

    Nathaniel L. Tulloch;Veronica Muskheli;Maria V. Razumova;F. Steven Korte

  • Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

    K. R. Stevens;K. L. Kreutziger;S. K. Dupras;F. S. Korte

  • Tri-iodo-L-thyronine Promotes the Maturation of Human Cardiomyocytes-Derived from Induced Pluripotent Stem Cells

    Xiulan Yang;Marita Rodriguez;Lil Pabon;Karin A. Fischer

  • Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue.

    Jia-Ling Ruan;Nathaniel L. Tulloch;Maria V. Razumova;Mark Saiget

  • A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

    Jennifer Davis;L. Craig Davis;Robert N. Correll;Catherine A. Makarewich

  • Skeletal and Cardiac Muscle Contractile Activation: Tropomyosin “Rocks and Rolls”

    A. M. Gordon;M. Regnier;E. Homsher

  • Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells

    Daniel Carson;Marketa Hnilova;Xiulan Yang;Cameron L. Nemeth

  • Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

    Andrea Leonard;Alessandro Bertero;Joseph D. Powers;Kevin M. Beussman

  • Substrate Stiffness Increases Twitch Power of Neonatal Cardiomyocytes in Correlation with Changes in Myofibril Structure and Intracellular Calcium

    Anthony G. Rodriguez;Sangyoon J. Han;Michael Regnier;Nathan J. Sniadecki

  • Epicardial cells derived from human embryonic stem cells augment cardiomyocyte-driven heart regeneration.

    Johannes Bargehr;Lay Ping Ong;Maria Colzani;Hongorzul Davaapil

  • Research Priorities in Hypertrophic Cardiomyopathy Report of a Working Group of the National Heart, Lung, and Blood Institute

    Thomas Force;Robert O. Bonow;Steven R. Houser;R. John Solaro

  • Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: Evidence for long-lived cross-bridges.

    Maria V. Razumova;Justin F. Shaffer;An Yue Tu;Galina V. Flint

  • Mechanical Stress Promotes Maturation of Human Myocardium from Pluripotent Stem Cell-Derived Progenitors

    Jia Ling Ruan;Nathaniel L. Tulloch;Mark Saiget;Sharon L. Paige

  • Regulation of the cross-bridge transition from a weakly to strongly bound state in skinned rabbit muscle fibers

    M. Regnier;C. Morris;E. Homsher

  • The length–tension curve in muscle depends on lattice spacing

    C. David Williams;Mary K. Salcedo;Thomas C. Irving;Michael Regnier

  • Sarcomere lattice geometry influences cooperative myosin binding in muscle.

    Bertrand C. W Tanner;Thomas L Daniel;Michael Regnier

  • ATP Analogs and Muscle Contraction: Mechanics and Kinetics of Nucleoside Triphosphate Binding and Hydrolysis

    M. Regnier;D.M. Lee;E. Homsher

  • 2-Deoxy-ATP Enhances Contractility of Rat Cardiac Muscle

    M. Regnier;A. J. Rivera;Y. Chen;P. B. Chase

Frequent Co-Authors

Charles E. Murry
Charles E. Murry University of Washington
Andrew D. McCulloch
Andrew D. McCulloch University of California, San Diego
Michael J. Bamshad
Michael J. Bamshad University of Washington
Deok-Ho Kim
Deok-Ho Kim Johns Hopkins University
Michael A. Geeves
Michael A. Geeves University of Kent
J. Andrew McCammon
J. Andrew McCammon University of California, San Diego
Valerie Daggett
Valerie Daggett University of Washington
Stephen D. Hauschka
Stephen D. Hauschka University of Washington
Jeffrey S. Chamberlain
Jeffrey S. Chamberlain University of Washington
Steven R. Houser
Steven R. Houser Temple University

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