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Overview

Michael A. Geeves is affiliated with the University of Kent in the United Kingdom. Their research spans fields primarily focused on Medicine with significant contributions to Biochemistry, Genetics, and Molecular Biology. Within these broader fields, their work concentrates on subfields such as Cardiology and Cardiovascular Medicine, Molecular Biology, Atomic and Molecular Physics and Optics, Cell Biology, and Cellular and Molecular Neuroscience.

The researcher's main topics of investigation include Cardiomyopathy and Myosin Studies, Cardiovascular Effects of Exercise, Muscle Physiology and Disorders, Cardiovascular Function and Risk Factors, Force Microscopy Techniques and Applications, Cardiac Pacing and Defibrillation Studies, and Cardiac Electrophysiology and Arrhythmias.

Among recent publications, notable papers authored by or involving Michael A. Geeves are:

  • MyBP-C: one protein to govern them all (2020), published in Journal of Muscle Research and Cell Motility
  • Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle (2022), published in Journal of Biological Chemistry
  • Alpha and beta myosin isoforms and human atrial and ventricular contraction (2021), published in Cellular and Molecular Life Sciences
  • Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments (2020), published in Biophysical Journal
  • Multiscale modeling of twitch contractions in cardiac trabeculae (2021), published in The Journal of General Physiology

Frequent collaborators include Michael Regnier, Saffie Mohran, Kristina B. Kooiker, Neil M. Kad, and Corrado Poggesi. These partnerships mark consistent co-authorship across various publications, indicating ongoing research networks and cooperation.

Michael A. Geeves's work is published extensively in several key scientific venues such as Biophysical Journal, bioRxiv (Cold Spring Harbor Laboratory), Journal of Biological Chemistry, The Journal of General Physiology, and Journal of Molecular and Cellular Cardiology. The Biophysical Journal hosts the largest number of their publications.

Best Publications

  • Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

    D. F. A. Mckillop;M. A. Geeves

  • Structural mechanism of muscle contraction.

    Michael A. Geeves;Kenneth C. Holmes

  • The Molecular Mechanism of Muscle Contraction

    Michael A. Geeves;Kenneth C. Holmes

  • Toxoplasma gondii myosin A and its light chain: a fast, single‐headed, plus‐end‐directed motor

    Angelika Herm‐Götz;Stefan Weiss;Rolf Stratmann;Rolf Stratmann;Setsuko Fujita‐Becker

  • Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.

    William Lehman;Victoria Hatch;Vicci Korman;Michael Rosol

  • Adenosine diphosphate and strain sensitivity in myosin motors.

    Miklós Nyitrai;Michael A Geeves

  • The use of actin labelled with N-(1-pyrenyl)iodoacetamide to study the interaction of actin with myosin subfragments and troponin/tropomyosin.

    A H Criddle;M A Geeves;T Jeffries

  • The dynamics of actin and myosin association and the crossbridge model of muscle contraction

    M A Geeves

  • Dynamics of the muscle thin filament regulatory switch: the size of the cooperative unit.

    M.A. Geeves;S.S. Lehrer

  • The muscle thin filament as a classical cooperative/allosteric regulatory system

    Sherwin S Lehrer;Michael A Geeves

  • The structural basis of muscle contraction

    Kenneth C. Holmes;Michael A. Geeves

  • Modulation of Actin Affinity and Actomyosin Adenosine Triphosphatase by Charge Changes in the Myosin Motor Domain

    Marcus Furch;Michael A. Geeves;Dietmar J. Manstein

  • A systematic nomenclature for mammalian tropomyosin isoforms

    Michael A. Geeves;Sarah E. Hitchcock-DeGregori;Peter W. Gunning

  • Myosin motors with artificial lever arms

    Michael Anson;Michael A. Geeves;Susanne E. Kurzawa;Dietmar J. Manstein

  • COOPERATIVITY AND SWITCHING WITHIN THE THREE-STATE MODEL OF MUSCLE REGULATION

    Robin Maytum;Sherwin S. Lehrer;Michael A. Geeves

  • Kinetics of acto-S1 interaction as a guide to a model for the crossbridge cycle

    M. A. Geeves;Roger S. Goody;H. Gutfreund

  • The Core FH2 Domain of Diaphanous-Related Formins Is an Elongated Actin Binding Protein that Inhibits Polymerization

    Atsushi Shimada;Miklós Nyitrai;Miklós Nyitrai;Ingrid R. Vetter;Dorothee Kühlmann

  • Cryptococcus neoformans Senses CO2 through the Carbonic Anhydrase Can2 and the Adenylyl Cyclase Cac1

    Estelle Geweiss Mogensen;Guilhem Janbon;James Chaloupka;Clemens Steegborn

  • Interaction of Actin and ADP with the Head Domain of Smooth Muscle Myosin: Implications for Strain-Dependent ADP Release in Smooth Muscle†

    Christine R. Cremo;Michael A. Geeves

  • Targeted amino-terminal acetylation of recombinant proteins in E. coli.

    Matthew Johnson;Arthur T. Coulton;Michael A. Geeves;Daniel P. Mulvihill

  • Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: characterization of two acto-S1-ADP complexes.

    Sally K. A. Woodward;John F. Eccleston;Michael A. Geeves

Frequent Co-Authors

Dietmar J. Manstein
Dietmar J. Manstein Hannover Medical School
Leslie A. Leinwand
Leslie A. Leinwand University of Colorado Boulder
Sherwin S. Lehrer
Sherwin S. Lehrer Boston Biomedical Research Institute
William Lehman
William Lehman Boston University
James A. Spudich
James A. Spudich Stanford University
Robert A. Cross
Robert A. Cross University of Warwick
David R. Trentham
David R. Trentham King's College London
Michael Regnier
Michael Regnier University of Washington
Charles Redwood
Charles Redwood University of Oxford
Hugh Watkins
Hugh Watkins University of Oxford

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